Search Results - "Pedro Pereira, José"

Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−​Desulfurization Chemistry by Thompson, Robert E, Liu, Xuyu, Alonso-García, Noelia, Pereira, Pedro José Barbosa, Jolliffe, Katrina A, Payne, Richard J

“…Native chemical ligation followed by desulfur­ization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding,…”
Get full text

Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods by Agten, Stijn M., Watson, Emma E., Ripoll‐Rozada, Jorge, Dowman, Luke J., Wu, Mike C. L., Alwis, Imala, Jackson, Shaun P., Pereira, Pedro José Barbosa, Payne, Richard J.

“…Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily…”
Get full text

Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions by Ferreira, Cecília, Pinto, Maria Filipa, Macedo-Ribeiro, Sandra, Pereira, Pedro José Barbosa, Rocha, Fernando Alberto, Martins, Pedro Miguel

“…When placed in the same environment, biochemically unrelated macromolecules influence each other's biological function through macromolecular crowding (MC)…”
Get more information

unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium by Santos, Joana A, Alonso-García, Noelia, Macedo-Ribeiro, Sandra, Pereira, Pedro José Barbosa

“…Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated…”
Get full text

Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming by Ford, Daniel J, Duggan, Nisharnthi M, Fry, Sarah E, Ripoll-Rozada, Jorge, Agten, Stijn M, Liu, Wenyu, Corcilius, Leo, Hackeng, Tilman M, van Oerle, Rene, Spronk, Henri M. H, Ashhurst, Anneliese S, Mini Sasi, Vishnu, Kaczmarski, Joe A, Jackson, Colin J, Pereira, Pedro José Barbosa, Passioura, Toby, Suga, Hiroaki, Payne, Richard J

“…The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and…”
Get full text

Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues by Dowman, Luke J, Agten, Stijn M, Ripoll-Rozada, Jorge, Calisto, Bárbara M, Pereira, Pedro José Barbosa, Payne, Richard J

“…Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In…”
Get more information

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides by Ripoll-Rozada, Jorge, Costa, Mafalda, Manso, José A., Maranha, Ana, Miranda, Vanessa, Sequeira, André, Ventura, M. Rita, Macedo-Ribeiro, Sandra, Pereira, Pedro José Barbosa, Empadinhas, Nuno

“…Mycobacteria are a wide group of organisms that includes strict pathogens, such as Mycobacterium tuberculosis, as well as environmental species known as…”
Get full text

Leech-Derived Thrombin Inhibitors: From Structures to Mechanisms to Clinical Applications by Corral-Rodríguez, María Ángeles, Macedo-Ribeiro, Sandra, Barbosa Pereira, Pedro José, Fuentes-Prior, Pablo

Get full text

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick by Macedo-Ribeiro, Sandra, Almeida, Carla, Calisto, Bárbara M, Friedrich, Thomas, Mentele, Reinhard, Stürzebecher, Jörg, Fuentes-Prior, Pablo, Pereira, Pedro José Barbosa

“…Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel…”
Get full text

What a difference a cluster makes: The multifaceted roles of IscR in gene regulation and DNA recognition by Santos, Joana A., Pereira, Pedro José Barbosa, Macedo-Ribeiro, Sandra

“…Iron–sulfur clusters are essential cofactors in a myriad of metabolic pathways. Therefore, their biogenesis is tightly regulated across a variety of organisms…”
Get full text

The tick-derived anticoagulant madanin is processed by thrombin and factor Xa by Figueiredo, Ana C, de Sanctis, Daniele, Pereira, Pedro José Barbosa

“…The cysteine-less peptidic anticoagulants madanin-1 and madanin-2 from the bush tick Haemaphysalis longicornis are the founding members of the MEROPS inhibitor…”
Get full text

Unconventional structure and mechanisms for membrane interaction and translocation of the NF-κB-targeting toxin AIP56 by Lisboa, Johnny, Pereira, Cassilda, Pinto, Rute D., Rodrigues, Inês S., Pereira, Liliana M. G., Pinheiro, Bruno, Oliveira, Pedro, Pereira, Pedro José Barbosa, Azevedo, Jorge E., Durand, Dominique, Benz, Roland, do Vale, Ana, dos Santos, Nuno M. S.

“…Bacterial AB toxins are secreted key virulence factors that are internalized by target cells through receptor-mediated endocytosis, translocating their…”
Get full text

SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97 by Almeida, Bruno, Abreu, Isabel A., Matos, Carlos A., Fraga, Joana S., Fernandes, Sara, Macedo, Maria G., Gutiérrez-Gallego, Ricardo, Pereira, Pedro José Barbosa, Carvalho, Ana Luísa, Macedo-Ribeiro, Sandra

“…Machado–Joseph Disease (MJD), a form of dominantly inherited ataxia belonging to the group of polyQ expansion neurodegenerative disorders, occurs when a…”
Get full text

Structural basis for host membrane remodeling induced by protein 2B of hepatitis A virus by Vives-Adrián, Laia, Garriga, Damià, Buxaderas, Mònica, Fraga, Joana, Pereira, Pedro José Barbosa, Macedo-Ribeiro, Sandra, Verdaguer, Núria

“…The complexity of viral RNA synthesis and the numerous participating factors require a mechanism to topologically coordinate and concentrate these multiple…”
Get full text

Rapid assembly and profiling of an anticoagulant sulfoprotein library by Watson, Emma E., Ripoll-Rozada, Jorge, Lee, Ashley C., Wu, Mike C. L., Franck, Charlotte, Pasch, Tim, Premdjee, Bhavesh, Sayers, Jessica, Pinto, Maria F., Martins, Pedro M., Jackson, Shaun P., Pereira, Pedro José Barbosa, Payne, Richard J.

“…Hematophagous organisms produce a suite of salivary proteins which interact with the host’s coagulation machinery to facilitate the acquisition and digestion…”
Get full text

The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation by Cereija, Tatiana Barros, Alarico, Susana, Lourenço, Eva C, Manso, José António, Ventura, M Rita, Empadinhas, Nuno, Macedo-Ribeiro, Sandra, Pereira, Pedro José Barbosa

“…Bacteria are challenged to adapt to environmental variations in order to survive. Under nutritional stress, several bacteria are able to slow down their…”
Get full text

Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics by Watson, Emma E., Liu, Xuyu, Thompson, Robert E., Ripoll-Rozada, Jorge, Wu, Mike, Alwis, Imala, Gori, Alessandro, Loh, Choy-Theng, Parker, Benjamin L., Otting, Gottfried, Jackson, Shaun, Pereira, Pedro José Barbosa, Payne, Richard J.

“…The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood…”
Get full text

Multi-objective Grammatical Evolution of Decision Trees for Mobile Marketing user conversion prediction by Pereira, Pedro José, Cortez, Paulo, Mendes, Rui

“…The worldwide adoption of mobile devices is raising the value of Mobile Performance Marketing, which is supported by Demand-Side Platforms (DSP) that match…”
Get full text

Tick-derived Kunitz-type inhibitors as antihemostatic factors by Corral-Rodríguez, María Ángeles, Macedo-Ribeiro, Sandra, Barbosa Pereira, Pedro José, Fuentes-Prior, Pablo

“…Endogenous Kunitz-type inhibitors target a large number of serine proteinases, including coagulation factors VIIa and Xa, but not thrombin. By contrast,…”
Get full text

Acute Ischemic Stroke in a Child Successfully Treated with Thrombolytic Therapy and Mechanical Thrombectomy by Souto Silva, Renata, Rodrigues, Rita, Reis Monteiro, Diana, Tavares, Susana, Pereira, José Pedro, Xavier, João, Melo, Cláudia, Ruano, Luís

“…Acute ischemic stroke in the pediatric population is rare but carries lasting and often lifelong morbidity. Thrombolysis and mechanical thrombectomy are…”
Get full text