Search Results - "Pedro J. Cejas"

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein by Tang, Aimin, Chen, Zhifeng, Cox, Kara S., Su, Hua-Poo, Callahan, Cheryl, Fridman, Arthur, Zhang, Lan, Patel, Sangita B., Cejas, Pedro J., Swoyer, Ryan, Touch, Sinoeun, Citron, Michael P., Govindarajan, Dhanasekaran, Luo, Bin, Eddins, Michael, Reid, John C., Soisson, Stephen M., Galli, Jennifer, Wang, Dai, Wen, Zhiyun, Heidecker, Gwendolyn J., Casimiro, Danilo R., DiStefano, Daniel J., Vora, Kalpit A.

“…Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant mortality under six months of age worldwide; therefore, the…”
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Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance by Han, Daehee, Walsh, Matthew C., Cejas, Pedro J., Dang, Nicholas N., Kim, Youngmi F., Kim, Jihyun, Charrier-Hisamuddin, Laetitia, Chau, Lillian, Zhang, Qin, Bittinger, Kyle, Bushman, Frederic D., Turka, Laurence A., Shen, Hao, Reizis, Boris, DeFranco, Anthony L., Wu, Gary D., Choi, Yongwon

“…The intracellular signaling molecule TRAF6 is critical for Toll-like receptor (TLR)-mediated activation of dendritic cells (DCs). We now report that…”
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Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection by Espeseth, Amy S., Cejas, Pedro J., Citron, Michael P., Wang, Dai, DiStefano, Daniel J., Callahan, Cheryl, Donnell, Gregory O’, Galli, Jennifer D., Swoyer, Ryan, Touch, Sinoeun, Wen, Zhiyun, Antonello, Joseph, Zhang, Lan, Flynn, Jessica A., Cox, Kara S., Freed, Daniel C., Vora, Kalpit A., Bahl, Kapil, Latham, Andrew H., Smith, Jeffrey S., Gindy, Marian E., Ciaramella, Giuseppe, Hazuda, Daria, Shaw, Christine A., Bett, Andrew J.

“…The RSV Fusion (F) protein is a target for neutralizing antibody responses and is a focus for vaccine discovery; however, the process of RSV entry requires F…”
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Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein by Flynn, Jessica A, Durr, Eberhard, Swoyer, Ryan, Cejas, Pedro J, Horton, Melanie S, Galli, Jennifer D, Cosmi, Scott A, Espeseth, Amy S, Bett, Andrew J, Zhang, Lan

“…Infection with Respiratory Syncytial Virus (RSV) causes both upper and lower respiratory tract disease in humans, leading to significant morbidity and…”
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Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation by Ng, Bruce, Cash-Mason, Tanesha, Wang, Yi, Seitzer, Jessica, Burchard, Julja, Brown, Duncan, Dudkin, Vadim, Davide, Joseph, Jadhav, Vasant, Sepp-Lorenzino, Laura, Cejas, Pedro J.

“…Clinical application of siRNA-based therapeutics outside of the liver has been hindered by the inefficient delivery of siRNA effector molecules into…”
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Reactive Oxygen Species Are Not Required for an Arsenic Trioxide-induced Antioxidant Response or Apoptosis by Morales, Alejo A., Gutman, Delia, Cejas, Pedro J., Lee, Kelvin P., Boise, Lawrence H.

“…Arsenicals are both environmental carcinogens as well as therapeutic agents for the treatment of trypanosomiasis and more recently cancer. Arsenic trioxide…”
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Enhancing CD8 T-cell memory by modulating fatty acid metabolism by Choi, Yongwon, Pearce, Erika L, Walsh, Matthew C, Cejas, Pedro J, Harms, Gretchen M, Shen, Hao, Wang, Li-San, Jones, Russell G

“…CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen stimulation undergo a…”
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EGR-2 is not required for in vivo CD4 T cell mediated immune responses by Ramón, Hilda E, Cejas, Pedro J, LaRosa, David, Rahman, Adeeb, Harris, John E, Zhang, Jidong, Hunter, Christopher, Choi, Yongwon, Turka, Laurence A

“…The zinc finger transcription factor EGR-2 has been shown to play an important role in the induction of T cell anergy and the regulation of peripheral T cell…”
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Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates by Zohar, Tomer, Hsiao, Jeff C., Mehta, Nickita, Das, Jishnu, Devadhasan, Anush, Karpinski, Wiktor, Callahan, Cheryl, Citron, Michael P., DiStefano, Daniel J., Touch, Sinoeun, Wen, Zhiyun, Sachs, Jeffrey R., Cejas, Pedro J., Espeseth, Amy S., Lauffenburger, Douglas A., Bett, Andrew J., Alter, Galit

“…Respiratory syncytial virus (RSV) infection is a major cause of respiratory illness in infants and the elderly. Although several vaccines have been developed,…”
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Evaluation of a stabilized RSV pre-fusion F mRNA vaccine: Preclinical studies and Phase 1 clinical testing in healthy adults by Nussbaum, Jesse, Cao, Xin, Railkar, Radha A., Sachs, Jeffrey R., Spellman, Daniel S., Luk, Julie, Shaw, Christine A., Cejas, Pedro J., Citron, Michael P., Al-Ibrahim, Mohamed, Han, David, Pagnussat, Sandra, Stoch, S. Aubrey, Lai, Eseng, Bett, Andrew J., Espeseth, Amy S.

“…Human respiratory syncytial virus (RSV) causes a substantial proportion of respiratory tract infections worldwide. Although RSV reinfections occur throughout…”
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Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates by Flynn, Jessica A., Weber, Teresa, Cejas, Pedro J., Cox, Kara S., Touch, Sinoeun, Austin, Lauren A., Ou, Yangsi, Citron, Michael P., Luo, Bin, Gindy, Marian E., Bahl, Kapil, Ciaramella, Giuseppe, Espeseth, Amy S., Zhang, Lan

“…In response to immune pressure, influenza viruses evolve, producing drifted variants capable of escaping immune recognition. One strategy for inducing a…”
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Regulation of RelB Expression during the Initiation of Dendritic Cell Differentiation by Cejas, Pedro J., Carlson, Louise M., Kolonias, Despina, Zhang, Jian, Lindner, Inna, Billadeau, Daniel D., Boise, Lawrence H., Lee, Kelvin P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Design and characterization of a fusion glycoprotein vaccine for Respiratory Syncytial Virus with improved stability by Zhang, Lan, Durr, Eberhard, Galli, Jennifer D., Cosmi, Scott, Cejas, Pedro J., Luo, Bin, Touch, Sinoeun, Parmet, Paul, Fridman, Arthur, Espeseth, Amy S., Bett, Andrew J.

“…Respiratory Syncytial Virus (RSV) infection is the leading cause of lower respiratory tract infection in both young children and older adults. Currently, there…”
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IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals by Walsh, Matthew C, Pearce, Erika L, Cejas, Pedro J, Lee, JangEun, Wang, Li-San, Choi, Yongwon

“…Naive T cell populations are maintained in the periphery at relatively constant levels via mechanisms that control expansion and contraction and are associated…”
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TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis by Choi, Yongwon, King, Carolyn G, Kobayashi, Takashi, Cejas, Pedro J, Kim, Taesoo, Yoon, Kwiyeom, Kim, Gregory K, Chiffoleau, Elise, Hickman, Somia P, Walsh, Patrick T, Turka, Laurence A

“…TRAF6 has a key role in the regulation of innate immune responses by mediating signals from both TNF receptor and interleukin-1 receptor/Toll-like receptor…”
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TRAF6 inhibits Th17 differentiation and TGF-β–mediated suppression of IL-2 by Cejas, Pedro J., Walsh, Matthew C., Pearce, Erika L., Han, Daehee, Harms, Gretchen M., Artis, David, Turka, Laurence A., Choi, Yongwon

“…Transforming growth factor-β (TGF-β) has an essential role in the generation of inducible regulatory T (iTreg) and T helper 17 (Th17) cells. However, little is…”
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Protein Kinase C βII Plays an Essential Role in Dendritic Cell Differentiation and Autoregulates Its Own Expression by Cejas, Pedro J., Carlson, Louise M., Zhang, Jian, Padmanabhan, Swami, Kolonias, Despina, Lindner, Inna, Haley, Stephen, Boise, Lawrence H., Lee, Kelvin P.

“…Dendritic cells (DC) arise from a diverse group of hematopoietic progenitors and have marked phenotypic and functional heterogeneity. The signal transduction…”
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Diminished expression of transcription factors nuclear factor κB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice by TORROELLA-KOURI, Marta, XIAOJING MA, PERRY, Giselle, IVANOVA, Milena, CEJAS, Pedro J, OWEN, Jennifer L, IRAGAVARAPU-CHARYULU, Vijaya, LOPEZ, Diana M

“…Interactions between malignant tumors and the host immune system shape the course of cancer progression. The molecular basis of such interactions is the…”
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Signal transduction in DC differentiation: winged messengers and Achilles' heel by Lindner, Inna, Cejas, Pedro J, Carlson, Louise M, Torruellas, Julie, Plano, Gregory V, Lee, Kelvin P

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Differentiation of acute and chronic myeloid leukemic blasts into the dendritic cell lineage: analysis of various differentiation-inducing signals by KHARFAN-DABAJA, Mohamed A, AYALA, Ernesto, LINDNER, Inna, CEJAS, Pedro J, BAHLIS, Nizar J, KOLONIAS, Despina, CARLSON, Louise M, LEE, Kelvin P

“…Ex vivo differentiation of myeloid leukemic blasts into dendritic cells (DCs) holds significant promise for use as cellular vaccines, as they may present a…”
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