Search Results - "Pedraz, J L"

Pharmacokinetics of Benznidazole in Healthy Volunteers and Implications in Future Clinical Trials by Molina, I, Salvador, F, Sánchez-Montalvá, A, Artaza, M A, Moreno, R, Perin, L, Esquisabel, A, Pinto, L, Pedraz, J L

“…Despite its toxicity and low efficacy in the chronic phase, benznidazole is the drug of choice in Chagas disease. Scarce information about pharmacokinetics and…”
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The state-of-the-art of approved and under-development cholera vaccines by Pastor, M, Pedraz, J.L, Esquisabel, A

“…Highlight • Cholera has re-emerged as a public health issue, mainly due to recent outbreaks. • Oral cholera vaccines are recommended by WHO since 1999 as a…”
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Protamine/DNA/Niosome Ternary Nonviral Vectors for Gene Delivery to the Retina: The Role of Protamine by Puras, G, Martínez-Navarrete, G, Mashal, M, Zárate, J, Agirre, M, Ojeda, E, Grijalvo, S, Eritja, R, Diaz-Tahoces, A, Avilés-Trigueros, M, Fernández, E, Pedraz, J. L

“…The present study aimed to evaluate the incorporation of protamine into niosome/DNA vectors to analyze the potential application of this novel ternary…”
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Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres by Gutierro, I, Hernández, R.M, Igartua, M, Gascón, A.R, Pedraz, J.L

“…BSA was entrapped in particles of different sizes (200, 500 and 1000 nm) prepared from poly( d, l-lactic-co-glycolic) acid by a double emulsion method. The…”
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Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy by del Pozo-Rodríguez, A., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Most studies in gene therapy are focused on developing more efficient non-viral vectors, ignoring their stability, even though physically and chemically stable…”
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A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors by del Pozo-Rodríguez, A., Pujals, S., Delgado, D., Solinís, M.A., Gascón, A.R., Giralt, E., Pedraz, J.L.

“…The aim of this work was to improve the transfection efficacy of solid lipid nanoparticle (SLN)-based non-viral vectors into ARPE-19 cells through the addition…”
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Solid lipid nanoparticles for retinal gene therapy: Transfection and intracellular trafficking in RPE cells by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Retinal pigment epithelial (RPE) cells are usually employed to study DNA systems for diseases related to problems in the retina. Solid lipid nanoparticles…”
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Solid lipid nanoparticles: Formulation factors affecting cell transfection capacity by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Since solid lipid nanoparticles (SLNs) were introduced as non-viral transfection systems, very few reports of their use for gene delivery have been published…”
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Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets by Espona-Noguera, A., Etxebarria-Elezgarai, J., Saenz del Burgo, L., Cañibano-Hernández, A., Gurruchaga, H., Blanco, F.J., Orive, G., Hernández, Rosa M., Benito-Lopez, F., Ciriza, J., Basabe-Desmonts, L., Pedraz, J.L.

“…[Display omitted] Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty…”
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Optimization of 100μm alginate-poly-l-lysine-alginate capsules for intravitreous administration by Santos, E., Orive, G., Calvo, A., Catena, R., Fernández-Robredo, P., Layana, A. García, Hernández, R.M., Pedraz, J.L.

“…The field of cell microencapsulation is advancing rapidly. Particle size plays a critical role in terms of biocompatibility and limits decisively its…”
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Low molecular-weight hyaluronan as a cryoprotectant for the storage of microencapsulated cells by Gurruchaga, H., Saenz del Burgo, L., Orive, G., Hernandez, R.M., Ciriza, J., Pedraz, J.L.

“…[Display omitted] The low-temperature storage of therapeutic cell-based products plays a crucial role in their clinical translation for the treatment of…”
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Biocompatibility Evaluation of Different Alginates and Alginate-Based Microcapsules by Orive, G, Carcaboso, A. M, Hernández, R. M, Gascón, A. R, Pedraz, J. L

“…Biocompatibility of biomaterials and biomaterial-based medical devices is a critical issue for the long-term function on multiple therapeutic systems. In the…”
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Topographical Distribution of Morphological Changes in a Partial Model of Parkinson’s Disease—Effects of Nanoencapsulated Neurotrophic Factors Administration by Requejo, C., Ruiz-Ortega, J. A., Bengoetxea, H., Garcia-Blanco, A., Herrán, E., Aristieta, A., Igartua, M., Ugedo, L., Pedraz, J. L., Hernández, R. M., Lafuente, J. V.

“…Administration of various neurotrophic factors is a promising strategy against Parkinson’s disease (PD). An intrastriatal infusion of 6-hydroxidopamine…”
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Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates by Orive, G, Ponce, S, Hernández, R.M, Gascón, A.R, Igartua, M, Pedraz, J.L

“…The biocompatibility of alginate-PLL-alginate (APA) microcapsules has been evaluated with respect to impurity levels. The impurity content of three different…”
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Novel extended-release formulation of lovastatin by one-step melt granulation: In vitro and in vivo evaluation by Ochoa, L., Igartua, M., Hernández, R.M., Gascón, A.R., Solinis, M.A., Pedraz, J.L.

“…The novel extended-release formulation of lovastatin developed exhibits zero-order release in vitro and provides extended plasma levels of lovastatin and its…”
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Cell Microencapsulation and Cryopreservation with Low Molecular Weight Hyaluronan and Dimethyl Sulfoxide by Gurruchaga, H, Del Burgo, L Saenz, Orive, G, M Hernandez, R, Ciriza, J, L Pedraz, J

“…Cryopreservation is commonly used for the storage of cells, tissues, organs or 3D cell-based products using ultra-low temperatures, which involves the…”
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Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes by Orive, Gorka, Emerich, Dwaine, Khademhosseini, Ali, Matsumoto, Shinichi, Hernández, R.M., Pedraz, J.L., Desai, Tejal, Calafiore, Riccardo, de Vos, Paul

“…Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membranes is an emerging treatment for type 1 diabetes. This…”
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Survival of different cell lines in alginate-agarose microcapsules by Orive, G, Hernández, R.M, Gascón, A.R, Igartua, M, Pedraz, J.L

“…Cell microencapsulation has emerged as a promising therapeutic strategy to treat a wide range of diseases. The optimisation of this technology depends on…”
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Pulmonary drug delivery: a review on nanocarriers for antibacterial chemotherapy by Moreno-Sastre, M, Pastor, M, Salomon, C J, Esquisabel, A, Pedraz, J L

“…As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a…”
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Development, characterization and sterilisation of Nanocellulose-alginate-(hyaluronic acid)- bioinks and 3D bioprinted scaffolds for tissue engineering by Lafuente-Merchan, M., Ruiz-Alonso, S., Espona-Noguera, A., Galvez-Martin, P., López-Ruiz, E., Marchal, J.A., López-Donaire, M.L., Zabala, A., Ciriza, J., Saenz-del-Burgo, L., Pedraz, J.L.

“…3D-bioprinting is an emerging technology of high potential in tissue engineering (TE), since it shows effective control over scaffold fabrication and cell…”
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