Search Results - "Pedraz, J"

Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes by Orive, Gorka, Emerich, Dwaine, Khademhosseini, Ali, Matsumoto, Shinichi, Hernández, R.M., Pedraz, J.L., Desai, Tejal, Calafiore, Riccardo, de Vos, Paul

“…Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membranes is an emerging treatment for type 1 diabetes. This…”
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Pulmonary drug delivery: a review on nanocarriers for antibacterial chemotherapy by Moreno-Sastre, M, Pastor, M, Salomon, C J, Esquisabel, A, Pedraz, J L

“…As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a…”
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Pharmacokinetics of Benznidazole in Healthy Volunteers and Implications in Future Clinical Trials by Molina, I, Salvador, F, Sánchez-Montalvá, A, Artaza, M A, Moreno, R, Perin, L, Esquisabel, A, Pinto, L, Pedraz, J L

“…Despite its toxicity and low efficacy in the chronic phase, benznidazole is the drug of choice in Chagas disease. Scarce information about pharmacokinetics and…”
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Application of cell encapsulation for controlled delivery of biological therapeutics by Orive, G., Santos, E., Pedraz, J.L., Hernández, R.M.

“…Cell microencapsulation technology is likely to have an increasingly important role in new approaches rather than the classical and pioneering organ…”
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Advanced nanovehicles for cancer management by Saenz del Burgo, L., Pedraz, J.L., Orive, G.

“…•Nano-vehicles can increase the efficacy of traditional drugs in cancer management.•A proper design of nanocarriers is as vital as the therapeutic loaded drug…”
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Advances in the slow freezing cryopreservation of microencapsulated cells by Gurruchaga, H, Saenz del Burgo, L, Hernandez, R.M, Orive, G, Selden, C, Fuller, B, Ciriza, J, Pedraz, J.L

“…Over the past few decades, the use of cell microencapsulation technology has been promoted for a wide range of applications as sustained drug delivery systems…”
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The state-of-the-art of approved and under-development cholera vaccines by Pastor, M, Pedraz, J.L, Esquisabel, A

“…Highlight • Cholera has re-emerged as a public health issue, mainly due to recent outbreaks. • Oral cholera vaccines are recommended by WHO since 1999 as a…”
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A novel cationic niosome formulation for gene delivery to the retina by Puras, G., Mashal, M., Zárate, J., Agirre, M., Ojeda, E., Grijalvo, S., Eritja, R., Diaz-Tahoces, A., Martínez Navarrete, G., Avilés-Trigueros, M., Fernández, E., Pedraz, J.L.

“…Niosomes represent a recent promising approach for gene delivery purposes. We elaborated on a novel niosome formulation based on the…”
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Biologically active and biomimetic dual gelatin scaffolds for tissue engineering by Sánchez, P., Pedraz, J.L., Orive, G.

“…[Display omitted] We have designed, developed and optimized Genipin cross-linked 3D gelatin scaffolds that were biologically active and biomimetic, show a dual…”
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Effectiveness of omalizumab in a case of urticarial vasculitis by Fueyo‐Casado, A., Campos‐Muñoz, L., González‐Guerra, E., Pedraz‐Muñoz, J., Cortés‐Toro, J. A., López‐Bran, E.

“…Summary Urticarial vasculitis (UV) is a mainly leucocytoclastic vasculitis with urticarial plaques. Treating these patients is challenging as the available…”
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The influence of the polar head-group of synthetic cationic lipids on the transfection efficiency mediated by niosomes in rat retina and brain by Ojeda, E, Puras, G, Agirre, M, Zarate, J, Grijalvo, S, Eritja, R, Martinez-Navarrete, G, Soto-Sánchez, C, Diaz-Tahoces, A, Aviles-Trigueros, M, Fernández, E, Pedraz, J.L

“…Abstract The development of novel non-viral delivery vehicles is essential in the search of more efficient strategies for retina and brain diseases. Herein,…”
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Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets by Espona-Noguera, A., Etxebarria-Elezgarai, J., Saenz del Burgo, L., Cañibano-Hernández, A., Gurruchaga, H., Blanco, F.J., Orive, G., Hernández, Rosa M., Benito-Lopez, F., Ciriza, J., Basabe-Desmonts, L., Pedraz, J.L.

“…[Display omitted] Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty…”
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Protamine/DNA/Niosome Ternary Nonviral Vectors for Gene Delivery to the Retina: The Role of Protamine by Puras, G, Martínez-Navarrete, G, Mashal, M, Zárate, J, Agirre, M, Ojeda, E, Grijalvo, S, Eritja, R, Diaz-Tahoces, A, Avilés-Trigueros, M, Fernández, E, Pedraz, J. L

“…The present study aimed to evaluate the incorporation of protamine into niosome/DNA vectors to analyze the potential application of this novel ternary…”
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Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres by Gutierro, I, Hernández, R.M, Igartua, M, Gascón, A.R, Pedraz, J.L

“…BSA was entrapped in particles of different sizes (200, 500 and 1000 nm) prepared from poly( d, l-lactic-co-glycolic) acid by a double emulsion method. The…”
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Killing effect of nanoencapsulated colistin sulfate on Pseudomonas aeruginosa from cystic fibrosis patients by Sans-Serramitjana, E, Fusté, E, Martínez-Garriga, B, Merlos, A, Pastor, M, Pedraz, J.L, Esquisabel, A, Bachiller, D, Vinuesa, T, Viñas, M

“…Abstract Pseudomonas aeruginosa frequently infects the respiratory tract of cystic fibrosis (CF) patients. Multidrug-resistant phenotypes and high capacity to…”
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Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy by del Pozo-Rodríguez, A., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Most studies in gene therapy are focused on developing more efficient non-viral vectors, ignoring their stability, even though physically and chemically stable…”
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Low molecular-weight hyaluronan as a cryoprotectant for the storage of microencapsulated cells by Gurruchaga, H., Saenz del Burgo, L., Orive, G., Hernandez, R.M., Ciriza, J., Pedraz, J.L.

“…[Display omitted] The low-temperature storage of therapeutic cell-based products plays a crucial role in their clinical translation for the treatment of…”
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A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors by del Pozo-Rodríguez, A., Pujals, S., Delgado, D., Solinís, M.A., Gascón, A.R., Giralt, E., Pedraz, J.L.

“…The aim of this work was to improve the transfection efficacy of solid lipid nanoparticle (SLN)-based non-viral vectors into ARPE-19 cells through the addition…”
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Solid lipid nanoparticles for retinal gene therapy: Transfection and intracellular trafficking in RPE cells by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Retinal pigment epithelial (RPE) cells are usually employed to study DNA systems for diseases related to problems in the retina. Solid lipid nanoparticles…”
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Niosomes based on synthetic cationic lipids for gene delivery: the influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells by Ojeda, E, Puras, G, Agirre, M, Zárate, J, Grijalvo, S, Pons, R, Eritja, R, Martinez-Navarrete, G, Soto-Sanchez, C, Fernández, E, Pedraz, J L

“…We designed niosomes based on three lipids that differed only in the polar-head group to analyze their influence on the transfection efficiency. These lipids…”
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