Comparative assessment of efficacy of tissue plasminogen activator and streptokinase in the treatment of patients with acute myocardial infarction

To compare results of treatment of patients with acute myocardial infarction with tissue plasminogen activator (TPA) and streptokinase. TPA (100 mg intravenously) and streptokinase (1500000 U intravenously) were used for thrombolytic therapy of acute myocardial infarction in 114 and 118 patients, re...

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Bibliographic Details
Published in:	Kardiologiia Vol. 44; no. 5; p. 40
Main Authors:	Shul'man, V A, Radionov, V V, Golovenkin, S E, Pediashov, V E, Linev, K A, Titarenko, O M, Simulin, V N, Pasal'skiĭ, V L, Peterson, L S, Necheporenko, G I, Kononova, L I, Peterson, E V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2004
Subjects:	Humans Myocardial Infarction - therapy Myocardial Reperfusion Streptokinase - therapeutic use Thrombolytic Therapy Tissue Plasminogen Activator - therapeutic use
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Summary:	To compare results of treatment of patients with acute myocardial infarction with tissue plasminogen activator (TPA) and streptokinase. TPA (100 mg intravenously) and streptokinase (1500000 U intravenously) were used for thrombolytic therapy of acute myocardial infarction in 114 and 118 patients, respectively. TPA treated compared with streptokinase treated patients were characterized by less frequent serious cardiac rhythm and conduction disturbances and hypotension during thrombolysis (p<0.05), as well as less frequent pathological Q-waves formation (p<0.001). More than 50% lowering of initially elevated ST-segment by 90-th minute occurred more often in TPA treated patients (p<0.001). Differences between TPA and streptokinase treated patients in mortality (3.5 and 7.6%, respectively), reinfarction rate during first 24 hours (3.5 and 5.1%, respectively), aneurysm formation (9.1 and 14.7%, respectively), and heart failure development (4.5 and 11.0%, respectively) were not significant. The use of TPA for thrombolytic therapy of patients with acute myocardial infarction gave better results than the use of streptokinase.
ISSN:	0022-9040