Search Results - "Pedersen, Stine F."

The Acidic Tumor Microenvironment as a Driver of Cancer by Boedtkjer, Ebbe, Pedersen, Stine F

“…Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity…”
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Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR) by Pedersen, Stine F., Okada, Yasunobu, Nilius, Bernd

“…The volume-regulated anion channel (VRAC), also known as the volume-sensitive outwardly rectifying (VSOR) anion channel or the volume-sensitive organic…”
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Physiology of Cell Volume Regulation in Vertebrates by Hoffmann, Else K, Lambert, Ian H, Pedersen, Stine F

“…Department of Biology, University of Copenhagen, Copenhagen, Denmark The ability to control cell volume is pivotal for cell function. Cell volume perturbation…”
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TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism by Miranda, Maria Zena, Bialik, Janne Folke, Speight, Pam, Dan, Qinghong, Yeung, Tony, Szászi, Katalin, Pedersen, Stine F., Kapus, András

“…Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-β1 (TGFβ) effector Smad3 regulate a common set of genes, can physically interact, and…”
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The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer by Pedersen, Stine F., Flinck, Mette, Pardo, Luis A.

“…Transport of ions and nutrients is a core mitochondrial function, without which there would be no mitochondrial metabolism and ATP production. Both ion…”
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Intracellular pH gradients in migrating cells by Martin, Christine, Pedersen, Stine F, Schwab, Albrecht, Stock, Christian

“…Cell polarization along the axis of movement is required for migration. The localization of proteins and regulators of the migratory machinery to either the…”
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Regulation and roles of bicarbonate transporters in cancer by Gorbatenko, Andrej, Olesen, Christina W, Boedtkjer, Ebbe, Pedersen, Stine F

“…A unifying feature of solid tumors is a markedly altered pH profile compared to normal tissues. This reflects that solid tumors, despite completely different…”
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Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin by Hendus-Altenburger, Ruth, Wang, Xinru, Sjøgaard-Frich, Lise M., Pedraz-Cuesta, Elena, Sheftic, Sarah R., Bendsøe, Anne H., Page, Rebecca, Kragelund, Birthe B., Pedersen, Stine F., Peti, Wolfgang

“…Very little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na + /H + -exchanger…”
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MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism by Petersen, Charlotte, Nielsen, Mette D., Andersen, Elise S., Basse, Astrid L., Isidor, Marie S., Markussen, Lasse K., Viuff, Birgitte M., Lambert, Ian H., Hansen, Jacob B., Pedersen, Stine F.

“…Adipose tissue takes up glucose and releases lactate, thereby contributing significantly to systemic glucose and lactate homeostasis. This implies the…”
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Contribution of Na+,HCO3−‐cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7) by Boedtkjer, Ebbe, Moreira, José M.A., Mele, Marco, Vahl, Pernille, Wielenga, Vera T., Christiansen, Peer M., Jensen, Vibeke E.D., Pedersen, Stine F., Aalkjaer, Christian

“…Genome‐wide association studies recently linked the locus for Na+,HCO3−‐cotransporter NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights…”
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Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4 by Lunda, Kathrine, Dmytriyeva, Oksana, Spahr, Louise, Goncalves-Alves, Eliana, Yao, Jiayi, Blasco, Laia P, Trauelsen, Mette, Ponniah, Muthulakshmi, Severin, Marc, Sandelin, Albin, Kveiborg, Marie, Schwartz, Thue W, Pedersen, Stine F

“…Abstract Background The lactate receptor GPR81 contributes to cancer development through unclear mechanisms. Here, we investigate the roles of GPR81 in…”
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Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes by Haxholm, Gitte W, Nikolajsen, Louise F, Olsen, Johan G, Fredsted, Jacob, Larsen, Flemming H, Goffin, Vincent, Pedersen, Stine F, Brooks, Andrew J, Waters, Michael J, Kragelund, Birthe B

“…Class 1 cytokine receptors regulate essential biological processes through complex intracellular signalling networks. However, the structural platform for…”
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The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration by Jensen, Helene H., Pedersen, Gitte A., Morgen, Jeanette J., Parsons, Maddy, Pedersen, Stine F., Nejsum, Lene N.

“…Key points Exogenous Na+/H+ exchanger 1 (NHE1) expression stimulated the collective migration of epithelial cell sheets Stimulation with epidermal growth…”
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration by Veland, Iben R, Montjean, Rodrick, Eley, Lorraine, Pedersen, Lotte B, Schwab, Albrecht, Goodship, Judith, Kristiansen, Karsten, Pedersen, Stine F, Saunier, Sophie, Christensen, Søren T

“…Inversin is a ciliary protein that critically regulates developmental processes and tissue homeostasis in vertebrates, partly through the degradation of…”
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TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling by Malinda, Raj R, Zeeberg, Katrine, Sharku, Patricia C, Ludwig, Mette Q, Pedersen, Lotte B, Christensen, Søren T, Pedersen, Stine F

“…Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related death, with a 5-year survival of <10% and severely limited treatment options. PDAC…”
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EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms by Schrøder, Jacob M, Larsen, Jesper, Komarova, Yulia, Akhmanova, Anna, Thorsteinsson, Rikke I, Grigoriev, Ilya, Manguso, Robert, Christensen, Søren T, Pedersen, Stine F, Geimer, Stefan, Pedersen, Lotte B

“…The microtubule (MT) plus-end-tracking protein EB1 is required for assembly of primary cilia in mouse fibroblasts, but the mechanisms involved and the roles of…”
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Cell volume regulation in epithelial physiology and cancer by Pedersen, Stine F, Hoffmann, Else K, Novak, Ivana

“…The physiological function of epithelia is transport of ions, nutrients, and fluid either in secretory or absorptive direction. All of these processes are…”
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The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 by Hendus-Altenburger, Ruth, Pedraz-Cuesta, Elena, Olesen, Christina W, Papaleo, Elena, Schnell, Jeff A, Hopper, Jonathan T S, Robinson, Carol V, Pedersen, Stine F, Kragelund, Birthe B

“…Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and…”
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The Intracellular Distal Tail of the Na+/H+ Exchanger NHE1 Is Intrinsically Disordered: Implications for NHE1 Trafficking by Nørholm, Ann-Beth, Hendus-Altenburger, Ruth, Bjerre, Gabriel, Kjaergaard, Magnus, Pedersen, Stine F, Kragelund, Birthe B

“…Intrinsic disorder is important for protein regulation, yet its role in regulation of ion transport proteins is essentially uninvestigated. The ubiquitous…”
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Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton by Ly, Donald L, Waheed, Faiza, Lodyga, Monika, Speight, Pam, Masszi, András, Nakano, Hiroyasu, Hersom, Maria, Pedersen, Stine F, Szászi, Katalin, Kapus, András

“…Hyperosmotic stress initiates several adaptive responses, including the remodeling of the cytoskeleton. Besides maintaining structural integrity, the…”
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