Search Results - "Pedersen, Philip J"

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents by Dalbøge, Louise S, Pedersen, Philip J, Hansen, Gitte, Fabricius, Katrine, Hansen, Henrik B, Jelsing, Jacob, Vrang, Niels

“…Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of…”
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Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism by West, Jason A, Tsakmaki, Anastasia, Ghosh, Soumitra S, Parkes, David G, Grønlund, Rikke V, Pedersen, Philip J, Maggs, David, Rajagopalan, Harith, Bewick, Gavin A

“…Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine…”
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Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass by Barkholt, Pernille, Pedersen, Philip J, Hay-Schmidt, Anders, Jelsing, Jacob, Hansen, Henrik H, Vrang, Niels

“…Abstract Objective The role of the central nervous system in mediating metabolic effects of Roux-en-Y gastric bypass (RYGB) surgery is poorly understood. Using…”
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Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice by Wismann, Pernille, Pedersen, Søren L., Hansen, Gitte, Mannerstedt, Karin, Pedersen, Philip J., Jeppesen, Palle B., Vrang, Niels, Fosgerau, Keld, Jelsing, Jacob

“…Analogues of several gastrointestinal peptide hormones have been developed into effective medicines for treatment of diseases such as type 2 diabetes mellitus…”
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457-P: Quantification of Vascular Density by 3D Light Sheet Imaging in a Surgical Ligation of the Left Anterior Descending Artery (LAD) Model in Mouse by ZOIS, NORA E., ROOSTALU, URMAS, THISTED, LOUISE, PEDERSEN, PHILIP J., FOSGERAU, KELD, JELSING, JACOB, VRANG, NIELS

“…Introduction: Patients with diabetes have an increased risk of cardiovascular disease including myocardial infarction (MI). A major consequence of MI is left…”
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An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins by Mannerstedt, Karin, Mishra, Narendra Kumar, Engholm, Ebbe, Lundh, Morten, Madsen, Charlotte S., Pedersen, Philip J., Le‐Huu, Priska, Pedersen, Søren L., Buch‐Månson, Nina, Borgström, Björn, Brimert, Thomas, Fink, Lisbeth N., Fosgerau, Keld, Vrang, Niels, Jensen, Knud J.

“…A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of…”
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Changes in heart rate, arrhythmia frequency, and cardiac biomarker values in horses during recovery after a long-distance endurance ride by Flethøj, Mette, Kanters, Jørgen K, Haugaard, Maria M, Pedersen, Philip J, Carstensen, Helena, Balling, Johanne D, Olsen, Lisbeth H, Buhl, Rikke

“…OBJECTIVE To evaluate heart rate, heart rate variability, and arrhythmia frequency as well as changes in cardiac biomarker values and their association with…”
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Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss by Barkholt, Pernille, Rigbolt, Kristoffer T. G., Falkenhahn, Mechthilde, Hübschle, Thomas, Schwahn, Uwe, Fernandez-Cachon, Maria Luisa, Schmidt, Thorsten, Theis, Stefan, Hansen, Henrik H., Hay-Schmidt, Anders, Pedersen, Philip J., Vrang, Niels, Jelsing, Jacob

“…The central mechanisms underlying the marked beneficial metabolic effects of bariatric surgery are unclear. Here, we characterized global gene expression in…”
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Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy by Thisted, Louise, Østergaard, Mette V., Pedersen, Annemarie A., Pedersen, Philip J., Lindsay, Ross T., Murray, Andrew J., Fink, Lisbeth N., Pedersen, Tanja X., Secher, Thomas, Johansen, Thea T., Thrane, Sebastian T., Skarsfeldt, Torben, Jelsing, Jacob, Thomsen, Morten B., Zois, Nora E.

“…Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments…”
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Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses by Trachsel, Dagmar S, Calloe, Kirstine, J Rgensen, Elin, Lunddahl, Christine S, Pedersen, Philip J, Kanters, J Rgen K, Klaerke, Dan A, Buhl, Rikke

“…To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG…”
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1103-P: Glucose-Responsive Insulin: An Unprecedented Cleavable Linker Concept by MANNERSTEDT, KARIN, ENGHOLM, EBBE, MISHRA, NARENDRA KUMAR, LUNDH, MORTEN, BUCH-MÅNSON, NINA, FINK, LISBETH N., PEDERSEN, SØREN LJUNGBERG, PEDERSEN, PHILIP J., LE-HUU, PRISKA, LAI, JOHNATHAN, JENSEN, KNUD J., FOSGERAU, KELD

“…Achieving the optimal combination of multiple glucose measurements and insulin injections provides a complex daily situation for most insulin-dependent…”
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Novel Rat Models of Diabetic Nephropathy Displaying Pronounced Tubular Fibrosis and Glomerular Alterations by SECHER, THOMAS, JOHANSEN, THEA T., OESTERGAARD, METTE V., PEDERSEN, PHILIP J., ZOIS, NORA E., PEDERSEN, TANJA X., VRANG, NIELS, FOSGERAU, KELD, FINK, LISBETH N.

“…Diabetic nephropathy (DN) is a long-term complication of diabetes characterized by proteinuria and loss of kidney function. Up to one third of patients with…”
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Novel "Dual Hit" Rat Model of Diabetic Cardiomyopathy by Thisted, Louise, Lindsay, Ross T, Fosgerau, Keld, Secher, Thomas, Thomsen, Morten B, Jespersen, Thomas, Murray, Andrew J, Pedersen, Philip J, Vrang, Niels, Fink, Lisbeth N, Pedersen, Tanja X, Zois, Nora E

“…The pathogenesis of diabetic cardiomyopathy (DC) is poorly understood and new drugs targeting the myocardium are absent. This may be ascribed to the failure of…”
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Molecular cloning and functional expression of the K+ channel KV7.1 and the regulatory subunit KCNE1 from equine myocardium by Pedersen, Philip J., Thomsen, Kirsten B., Flak, Jon B., Tejada, Maria A., Hauser, Frank, Trachsel, Dagmar, Buhl, Rikke, Kalbfleisch, Theodore, DePriest, Michael Scott, MacLeod, James N., Calloe, Kirstine, Klaerke, Dan A.

“…The voltage-gated K+-channel KV7.1 and the subunit KCNE1, encoded by the KCNQ1 and KCNE1 genes, respectively, are responsible for termination of the cardiac…”
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Normal electrocardiographic QT interval in race-fit Standardbred horses at rest and its rate dependence during exercise by Pedersen, Philip J., Kanters, Joergen K., Buhl, Rikke, Klaerke, Dan A.

“…Cardiac repolarization, measured as QT and Tpeak to Tend (TpTe) intervals on the ECG, is important, as irregularities caused by diseases, ventricular…”
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Corrigendum to “Molecular cloning and functional expression of the K+ channel KV7.1 and the regulatory subunit KCNE1 from equine myocardium” [Res. Vet. Sci. 113 (2017) 79–86] by Pedersen, Philip J., Thomsen, Kirsten B., Flak, Jon B., Tejada, Maria A., Hauser, Frank, Trachsel, Dagmar, Buhl, Rikke, Kalbfleisch, Theodore, DePriest, Michael Scott, MacLeod, James N., Calloe, Kirstine, Klaerke, Dan A.

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Appropriate threshold levels of cardiac beat-to-beat variation in semi-automatic analysis of equine ECG recordings by Flethøj, Mette, Kanters, Jørgen K, Pedersen, Philip J, Haugaard, Maria M, Carstensen, Helena, Olsen, Lisbeth H, Buhl, Rikke

“…Although premature beats are a matter of concern in horses, the interpretation of equine ECG recordings is complicated by a lack of standardized analysis…”
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Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium by Pedersen, Philip J, Thomsen, Kirsten B, Flak, Jon B, Tejada, Maria A, Hauser, Frank, Trachsel, Dagmar, Buhl, Rikke, Kalbfleisch, Theodore, DePriest, Michael Scott, MacLeod, James N, Calloe, Kirstine, Klaerke, Dan A

“…The voltage-gated K -channel K 7.1 and the subunit KCNE1, encoded by the KCNQ1 and KCNE1 genes, respectively, are responsible for termination of the cardiac…”
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Diurnal modulation and sources of variation affecting ventricular repolarization in Warmblood horses by Pedersen, Philip J., Moeller, Sine B., Flethøj, Mette, Kanters, Joergen K., Buhl, Rikke, Klaerke, Dan A.

“…Irregularities in cardiac repolarization are known to predispose for arrhythmias and sudden cardiac death in humans. The QT interval is a quantitative…”
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ZGN-1061, a Novel MetAP2 Inhibitor, and Liraglutide Combine to Improve Glycemic Control and Reduce Body Weight in a Rat Model of Diet-Induced Obesity by BURKEY, BRYAN F., PEDERSEN, PHILIP J., PEDERSEN, TANJA X., FEIGH, MICHAEL, VATH, JAMES, HUGHES, THOMAS E.

“…ZGN-1061 (1061) is a methionine aminopeptidase 2 (MetAP2) inhibitor being developed to improve glycemic control in T2D. This study investigated 5 weeks (weeks)…”
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