Search Results - "Pedersen, P. P"

Crystal structure of the sodium-potassium pump by Vilsen, Bente, Nissen, Poul, Morth, J. Preben, Pedersen, Bjørn P, Toustrup-Jensen, Mads S, Sørensen, Thomas L.-M, Petersen, Janne, Andersen, Jens Peter

“…The Na+,K+-ATPase generates electrochemical gradients for sodium and potassium that are vital to animal cells, exchanging three sodium ions for two potassium…”
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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans by Holth, Jerrah K, Fritschi, Sarah K, Wang, Chanung, Pedersen, Nigel P, Cirrito, John R, Mahan, Thomas E, Finn, Mary Beth, Manis, Melissa, Geerling, Joel C, Fuller, Patrick M, Lucey, Brendan P, Holtzman, David M

“…The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD)…”
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Photometry and performance of SPECULOOS-South by Murray, C A, Delrez, L, Pedersen, P P, Queloz, D, Gillon, M, Burdanov, A, Ducrot, E, Garcia, L J, Lienhard, F, Demory, B O, Jehin, E, McCormac, J, Sebastian, D, Sohy, S, Thompson, S J, Triaud, A H M J, Grootel, V V, Günther, M N, Huang, C X

“…ABSTRACT SPECULOOS-South, an observatory composed of four independent 1-m robotic telescopes, located at ESO Paranal, Chile, started scientific operation in…”
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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides by Kapoor, Khyati, Finer-Moore, Janet S., Pedersen, Bjørn P., Caboni, Laura, Waight, Andrew, Hillig, Roman C., Bringmann, Peter, Heisler, Iring, Müller, Thomas, Siebeneicher, Holger, Stroud, Robert M.

“…Cancerous cells have an acutely increased demand for energy, leading to increased levels of human glucose transporter 1 (hGLUT1). This up-regulation suggests…”
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Crystal structure of the plasma membrane proton pump by PEDERSEN, Bjørn P, BUCH-PEDERSEN, Morten J, MORTH, J. Preben, PALMGREN, Michael G, NISSEN, Poul

“…A prerequisite for life is the ability to maintain electrochemical imbalances across biomembranes. In all eukaryotes the plasma membrane potential and…”
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Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria by Mathupala, S P, Ko, Y H, Pedersen, P L

“…A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically…”
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Crystal structure of a eukaryotic phosphate transporter by Pedersen, Bjørn P., Kumar, Hemant, Waight, Andrew B., Risenmay, Aaron J., Roe-Zurz, Zygy, Chau, Bryant H., Schlessinger, Avner, Bonomi, Massimiliano, Harries, William, Sali, Andrej, Johri, Atul K., Stroud, Robert M.

“…The X-ray crystal structure of a high-affinity phosphate importer in an inward-facing, occluded state in the presence of phosphate is reported; this is the…”
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Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion by Sleire, L, Skeie, B S, Netland, I A, Førde, H E, Dodoo, E, Selheim, F, Leiss, L, Heggdal, J I, Pedersen, P-H, Wang, J, Enger, P Ø

“…Glioblastomas (GBMs) are aggressive brain tumors that always recur after radiotherapy. Cystine, mainly provided by the system X c − antiporter, is a…”
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Basal forebrain control of wakefulness and cortical rhythms by Anaclet, Christelle, Pedersen, Nigel P., Ferrari, Loris L., Venner, Anne, Bass, Caroline E., Arrigoni, Elda, Fuller, Patrick M.

“…Wakefulness, along with fast cortical rhythms and associated cognition, depend on the basal forebrain (BF). BF cholinergic cell loss in dementia and the…”
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Reassessment of the structural basis of the ascending arousal system by Fuller, Patrick, Sherman, David, Pedersen, Nigel P., Saper, Clifford B., Lu, Jun

“…The “ascending reticular activating system” theory proposed that neurons in the upper brainstem reticular formation projected to forebrain targets that…”
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A structural overview of the plasma membrane Na + ,K + -ATPase and H + -ATPase ion pumps by Nissen, Poul, Morth, J. Preben, Pedersen, Bjørn P, Buch-Pedersen, Morten J, Andersen, Jens Peter, Vilsen, Bente, Palmgren, Michael G

“…Key Points Ions are transported across the plasma membrane by molecular pumps to generate chemical gradients and regulate pH or cell growth. P-type ATPases are…”
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Supramammillary glutamate neurons are a key node of the arousal system by Pedersen, Nigel P., Ferrari, Loris, Venner, Anne, Wang, Joshua L., Abbott, Stephen B. G., Vujovic, Nina, Arrigoni, Elda, Saper, Clifford B., Fuller, Patrick M.

“…Basic and clinical observations suggest that the caudal hypothalamus comprises a key node of the ascending arousal system, but the cell types underlying this…”
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A Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids by Chen, Tiffany Q., Pedersen, P. Scott, Dow, Nathan W., Fayad, Remi, Hauke, Cory E., Rosko, Michael C., Danilov, Evgeny O., Blakemore, David C., Dechert-Schmitt, Anne-Marie, Knauber, Thomas, Castellano, Felix N., MacMillan, David W. C.

“…Aryl halides are a fundamental motif in synthetic chemistry, playing a critical role in metal-mediated cross-coupling reactions and serving as important…”
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Decarboxylative Borylation and Cross-Coupling of (Hetero)aryl Acids Enabled by Copper Charge Transfer Catalysis by Dow, Nathan W, Pedersen, P. Scott, Chen, Tiffany Q, Blakemore, David C, Dechert-Schmitt, Anne-Marie, Knauber, Thomas, MacMillan, David W. C

“…We report a copper-catalyzed strategy for arylboronic ester synthesis that exploits photoinduced ligand-to-metal charge transfer (LMCT) to convert…”
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One-Pot Synthesis of Sulfonamides from Unactivated Acids and Amines via Aromatic Decarboxylative Halosulfonylation by Pedersen, P. Scott, Blakemore, David C., Chinigo, Gary M., Knauber, Thomas, MacMillan, David W. C.

“…The coupling of carboxylic acids and amines to form amide linkages is the most commonly performed reaction in the pharmaceutical industry. Herein, we report a…”
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Preparation of Ultracold Atom Clouds at the Shot Noise Level by Gajdacz, M, Hilliard, A J, Kristensen, M A, Pedersen, P L, Klempt, C, Arlt, J J, Sherson, J F

“…We prepare number stabilized ultracold atom clouds through the real-time analysis of nondestructive images and the application of feedback. In our experiments,…”
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Ship collision damage assessment and validation with experiments and numerical simulations by Zhang, Shengming, Villavicencio, R., Zhu, L., Pedersen, P. Terndrup

“…Closed-form expressions to estimate the energy absorption and damage extent for severe ship collision damages were initially developed in 1999 [1, 2], and…”
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Structural basis for potassium transport in prokaryotes by KdpFABC by Sweet, Marie E., Larsen, Casper, Zhang, Xihui, Schlame, Michael, Pedersen, Bjørn P., Stokes, David L.

“…KdpFABC is an oligomeric K⁺ transport complex in prokaryotes that maintains ionic homeostasis under stress conditions. The complex comprises a channel-like…”
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Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal by Kaur, Satvinder, Pedersen, Nigel P, Yokota, Shigefumi, Hur, Elizabeth E, Fuller, Patrick M, Lazarus, Michael, Chamberlin, Nancy L, Saper, Clifford B

“…The mechanisms of arousal from apneas during sleep in patients suffering from obstructive sleep apnea are not well understood. However, we know that…”
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Characterising organic matter in recirculating aquaculture systems with fluorescence EEM spectroscopy by Hambly, A.C., Arvin, E., Pedersen, L.-F., Pedersen, P.B., Seredyńska-Sobecka, B., Stedmon, C.A.

“…The potential of recirculating aquaculture systems (RAS) in the aquaculture industry is increasingly being acknowledged. Along with intensified application,…”
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