Search Results - "Pedersen, Lars C"

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase by Jin, Da-Yun, Chen, Xuejie, Liu, Yizhou, Williams, Craig M., Pedersen, Lars C., Stafford, Darrel W., Tie, Jian-Ke

“…Vitamin K is a vital micronutrient implicated in a variety of human diseases. Warfarin, a vitamin K antagonist, is the most commonly prescribed oral…”
Get full text

Replication infidelity via a mismatch with Watson-Crick geometry by Bebenek, Katarzyna, Pedersen, Lars C, Kunkel, Thomas A

“…In describing the DNA double helix, Watson and Crick suggested that "spontaneous mutation may be due to a base occasionally occurring in one of its less likely…”
Get full text

Structures of the mitochondrial single-stranded DNA binding protein with DNA and DNA polymerase γ by Riccio, Amanda A, Bouvette, Jonathan, Pedersen, Lars C, Somai, Shruti, Dutcher, Robert C, Borgnia, Mario J, Copeland, William C

“…The mitochondrial single-stranded DNA (ssDNA) binding protein, mtSSB or SSBP1, binds to ssDNA to prevent secondary structures of DNA that could impede…”
Get full text

Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy by LaHood, Nicole A, Min, Jungki, Keswani, Tarun, Richardson, Crystal M, Amoako, Kwasi, Zhou, Jingjia, Marini-Rapoport, Orlee, Bernard, Hervé, Hazebrouck, Stéphane, Shreffler, Wayne G, Love, J Christopher, Pomes, Anna, Pedersen, Lars C, Mueller, Geoffrey A, Patil, Sarita U

“…In IgE-mediated food allergies, exposure to the allergen activates systemic allergic responses. Oral immunotherapy (OIT) treats food allergies through…”
Get full text

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism by Batra, Vinod K., Beard, William A., Pedersen, Lars C., Wilson, Samuel H.

“…High-fidelity DNA synthesis requires that polymerases display a strong preference for right nucleotide insertion. When the wrong nucleotide is inserted,…”
Get full text

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining by Kaminski, Andrea M., Chiruvella, Kishore K., Ramsden, Dale A., Bebenek, Katarzyna, Kunkel, Thomas A., Pedersen, Lars C.

“…DNA double-strand breaks (DSBs) threaten genomic stability, since their persistence can lead to loss of critical genetic information, chromosomal…”
Get full text

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action by Jamsen, Joonas A., Beard, William A., Pedersen, Lars C., Shock, David D., Moon, Andrea F., Krahn, Juno M., Bebenek, Katarzyna, Kunkel, Thomas A., Wilson, Samuel H.

“…DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides during gap-filling synthesis in the non-homologous end-joining pathway of…”
Get full text

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis by Kaminski, Andrea M., Tumbale, Percy P., Schellenberg, Matthew J., Williams, R. Scott, Williams, Jason G., Kunkel, Thomas A., Pedersen, Lars C., Bebenek, Katarzyna

“…DNA ligase IV (LigIV) performs the final DNA nick-sealing step of classical nonhomologous end-joining, which is critical for immunoglobulin gene maturation and…”
Get full text

Anticoagulant heparan sulfate: structural specificity and biosynthesis by Liu, Jian, Pedersen, Lars C

“…Heparan sulfate (HS) is present on the surface of endothelial and surrounding tissues in large quantities. It plays important roles in regulating numerous…”
Get full text

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu by Moon, Andrea F, Pryor, John M, Ramsden, Dale A, Kunkel, Thomas A, Bebenek, Katarzyna, Pedersen, Lars C

“…While most DNA polymerases discriminate against ribonucleotide triphosphate (rNTP) incorporation very effectively, the Family X member DNA polymerase μ (Pol μ)…”
Get full text

Heparan sulfate promotes TRAIL-induced tumor cell apoptosis by Luo, Yin, Hao, Huanmeng, Wang, Zhangjie, Ong, Chih Yean, Dutcher, Robert, Xu, Yongmei, Liu, Jian, Pedersen, Lars C, Xu, Ding

“…TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a…”
Get full text

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break by Kaminski, Andrea M., Pryor, John M., Ramsden, Dale A., Kunkel, Thomas A., Pedersen, Lars C., Bebenek, Katarzyna

“…Genomic integrity is threatened by cytotoxic DNA double-strand breaks (DSBs), which must be resolved efficiently to prevent sequence loss, chromosomal…”
Get full text

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification by Pham, Phuong, Afif, Samir A., Shimoda, Mayuko, Maeda, Kazuhiko, Sakaguchi, Nobuo, Pedersen, Lars C., Goodman, Myron F.

“…Activation-induced deoxycytidine deaminase (AID) initiates somatic hypermutation (SHM) and class-switch recombination (CSR) by deaminating C→U during…”
Get full text

Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies by Li, Miaomiao, Pedersen, Lars C, Xu, Ding

“…Heparan sulfate-binding proteins (HSBPs) are structurally diverse extracellular and membrane attached proteins that interact with HS under normal physiological…”
Get full text

The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment by Mueller, Geoffrey A., PhD, Pedersen, Lars C., PhD, Lih, Fred B., BA, Glesner, Jill, BS, Moon, Andrea F., MS, Chapman, Martin D., PhD, Tomer, Kenneth B., PhD, London, Robert E., PhD, Pomés, Anna, PhD

“…Background Sensitization to cockroach allergens is a major risk factor for asthma. The cockroach allergen Bla g 1 has multiple repeats of approximately 100…”
Get full text

Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis by Mueller, Geoffrey A., PhD, Pedersen, Lars C., PhD, Glesner, Jill, BS, Edwards, Lori L., BS, Zakzuk, Josefina, MD, PhD, London, Robert E., PhD, Arruda, L. Karla, MD, PhD, Chapman, Martin D., PhD, Caraballo, Luis, MD, PhD, Pomés, Anna, PhD

“…Background It is not clear whether cross-reactivity or cosensitization to glutathione S-transferases (GSTs) occurs in tropical and subtropical environments. In…”
Get full text

Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine by Kaminski, Andrea M, Chiruvella, Kishore K, Ramsden, Dale A, Kunkel, Thomas A, Bebenek, Katarzyna, Pedersen, Lars C

“…DNA double-strand breaks (DSBs) resulting from reactive oxygen species generated by exposure to UV and ionizing radiation are characterized by clusters of…”
Get full text

Creative template-dependent synthesis by human polymerase mu by Moon, Andrea F., Gosavi, Rajendrakumar A., Kunkel, Thomas A., Pedersen, Lars C., Bebenek, Katarzyna

“…Among the many proteins used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymerases, Pol λ and Pol μ…”
Get full text

100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology by Pomés, Anna, PhD, Chruszcz, Maksymilian, PhD, Gustchina, Alla, PhD, Minor, Wladek, PhD, Mueller, Geoffrey A., PhD, Pedersen, Lars C., PhD, Wlodawer, Alexander, PhD, Chapman, Martin D., PhD

“…Current knowledge of molecules involved in immunology and allergic disease results from the significant contributions of x-ray crystallography, a discipline…”
Get full text

Structure–function analysis of ribonucleotide bypass by B family DNA replicases by Clausen, Anders R., Murray, Michael S., Passer, Andrew R., Pedersen, Lars C., Kunkel, Thomas A.

“…Ribonucleotides are frequently incorporated into DNA during replication, they are normally removed, and failure to remove them results in replication stress…”
Get full text