Search Results - "Pedersen, B K"

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases by Pedersen, B. K., Saltin, B.

“…This review provides the reader with the up‐to‐date evidence‐based basis for prescribing exercise as medicine in the treatment of 26 different diseases:…”
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Evidence for prescribing exercise as therapy in chronic disease by Pedersen, B. K., Saltin, B.

“…Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including…”
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Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase by Matthews, V. B, Åström, M.-B, Chan, M. H. S, Bruce, C. R, Krabbe, K. S, Prelovsek, O, Åkerström, T, Yfanti, C, Broholm, C, Mortensen, O. H, Penkowa, M, Hojman, P, Zankari, A, Watt, M. J, Bruunsgaard, H, Pedersen, B. K, Febbraio, M. A

“…Aims/hypothesis Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the…”
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Interaction of Amyloid-β-(1–42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy by Strazdaite, S, Roeters, S. J, Sakalauskas, A, Sneideris, T, Kirschner, J, Pedersen, K. B, Schiøtt, B, Jensen, F, Weidner, T, Smirnovas, V, Niaura, G

“…In this study, we use surface-sensitive vibrational sum-frequency generation (VSFG) spectroscopy to investigate the interaction between model lipid monolayers…”
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Brain-derived neurotrophic factor (BDNF) and type 2 diabetes by Krabbe, K. S, Nielsen, A. R, Krogh-Madsen, R, Plomgaard, P, Rasmussen, P, Erikstrup, C, Fischer, C. P, Lindegaard, B, Petersen, A. M. W, Taudorf, S, Secher, N. H, Pilegaard, H, Bruunsgaard, H, Pedersen, B. K

“…Aims/hypothesis Decreased levels of brain-derived neurotrophic factor (BDNF) have been implicated in the pathogenesis of Alzheimer's disease and depression…”
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Liver and Muscle Contribute Differently to the Plasma Acylcarnitine Pool During Fasting and Exercise in Humans by Xu, G, Hansen, J. S, Zhao, X. J, Chen, S, Hoene, M, Wang, X. L, Clemmesen, J. O, Secher, N. H, Häring, H. U, Pedersen, B. K, Lehmann, R, Weigert, Cora, Plomgaard, Peter

“…Background: Plasma acylcarnitine levels are elevated by physiological conditions such as fasting and exercise but also in states of insulin resistance and…”
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Human endotoxemia as a model of systemic inflammation by Andreasen, A S, Krabbe, K S, Krogh-Madsen, R, Taudorf, S, Pedersen, B K, Møller, K

“…Systemic inflammation is a pathogenetic component in a vast number of acute and chronic diseases such as sepsis, trauma, type 2 diabetes, atherosclerosis, and…”
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Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro by Petersen, E W, Carey, A L, Sacchetti, M, Steinberg, G R, Macaulay, S L, Febbraio, M A, Pedersen, B K

“…To determine whether IL-6 increases lipolysis and fat oxidation in patients with type 2 diabetes and/or whether it exerts this effect independently of changes…”
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The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? by Pedersen, B. K., Steensberg, A., Fischer, C., Keller, C., Keller, P., Plomgaard, P., Wolsk-Petersen, E., Febbraio, M.

“…For most of the last century, researchers have searched for a muscle contraction-induced factor that mediates some of the exercise effects in other tissues…”
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Soluble CD163: a biomarker linking macrophages and insulin resistance by Parkner, T., Sørensen, L. P., Nielsen, A. R., Fischer, C. P., Bibby, B. M., Nielsen, S., Pedersen, B. K., Møller, H. J.

“…Aims/hypothesis Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163…”
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The Effect of Strength and Endurance Training on Insulin Sensitivity and Fat Distribution in Human Immunodeficiency Virus-Infected Patients with Lipodystrophy by Lindegaard, B., Hansen, T., Hvid, T., van Hall, G., Plomgaard, P., Ditlevsen, S., Gerstoft, J., Pedersen, B. K.

“…Context: Fat redistribution, insulin resistance, and low-grade inflammation characterize HIV-infected patients with lipodystrophy. Currently, no effective…”
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Alpha adrenergic receptor blockade increases capillarization and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle by Mortensen, S. P., Egginton, S., Madsen, M., Hansen, J. B., Munch, G. D. W., Iepsen, U. W., Åkerström, T., Pedersen, B. K., Hellsten, Y.

“…Aim To assess the effect of elevated basal shear stress on angiogenesis in humans and the role of enhanced skeletal muscle capillarization on blood flow and O2…”
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Associations between insulin resistance and TNF-α in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes by Plomgaard, P, Nielsen, A. R, Fischer, C. P, Mortensen, O. H, Broholm, C, Penkowa, M, Krogh-Madsen, R, Erikstrup, C, Lindegaard, B, Petersen, A. M. W, Taudorf, S, Pedersen, B. K

“…Aims/hypothesis Clear evidence exists that TNF-α inhibits insulin signalling and thereby glucose uptake in myocytes and adipocytes. However, conflicting…”
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Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running by Ostrowski, K., Rohde, T., Zacho, M., Asp, S., Pedersen, B. K.

“…This study was performed to test the hypothesis that inflammatory cytokines are produced in skeletal muscle in response to prolonged intense exercise. Muscle…”
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Predicting death from tumour necrosis factor‐alpha and interleukin‐6 in 80‐year‐old people by BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., PEDERSEN, B. K.

“…SUMMARY Ageing is associated with low‐grade inflammation and markers such as IL‐6 possess prognostic value. Tumour necrosis‐alpha (TNF‐α) initiates the…”
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Ageing, tumour necrosis factor‐alpha (TNF‐α) and atherosclerosis by Bruunsgaard, H., Skinhøj, P., Pedersen, A. N., Schroll, M., Pedersen, B. K.

“…Ageing is associated with increased inflammatory activity in the blood. The purpose of this study was to investigate if age‐related increased plasma levels of…”
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Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin by Lindegaard, B., Ditlevsen, S., Plomgaard, P., Mittendorfer, B., Pedersen, B. K.

“…Aims/hypothesis Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity,…”
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Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles by Jonsdottir, I. H., Schjerling, P., Ostrowski, K., Asp, S., Richter, E. A., Pedersen, B. K.

“…The present study explored the hypothesis that interleukin-6 (IL-6) might be locally produced in response to skeletal muscle contractions and whether the…”
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Possible beneficial role of exercise in modulating low-grade inflammation in the elderly by Pedersen, B. K., Bruunsgaard, H.

“…Aging is associated with increased levels of tumor necrosis factor‐α (TNF) and interleukin (IL)‐6. These two cytokines are tightly linked in that TNF induces…”
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Physical Activity Enhances Metabolic Fitness Independently of Cardiorespiratory Fitness in Marathon Runners by Knudsen, T., Hansen, L. S., Nielsen, M. B., Laye, M. J., Pedersen, Bente Klarlund

“…High levels of cardiovascular fitness (CRF) and physical activity (PA) are associated with decreased mortality and risk to develop metabolic diseases. The…”
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