Search Results - "Peden, Keith"

Development of mRNA Vaccines: Scientific and Regulatory Issues by Knezevic, Ivana, Liu, Margaret A, Peden, Keith, Zhou, Tiequn, Kang, Hye-Na

“…The global research and development of mRNA vaccines have been prodigious over the past decade, and the work in this field has been stimulated by the urgent…”
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GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous neoplasia that created the AGMK1-9T7 cell line by Lewis, Jr, Andrew M, Foseh, Gideon, Tu, Wei, Peden, Keith, Akue, Adovi, KuKuruga, Mark, Rotroff, Daniel, Lewis, Gladys, Mazo, Ilya, Bauer, Steven R

“…The AGMK1-9T7 cell line has been used to study neoplasia in tissue culture. By passage in cell culture, these cells evolved to become tumorigenic and…”
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The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells by Lewis, Andrew M, Thomas, Rachael, Breen, Matthew, Peden, Keith, Teferedegne, Belete, Foseh, Gideon, Motsinger-Reif, Alison, Rotroff, Daniel, Lewis, Gladys

“…To study neoplasia in tissue culture, cell lines representing the evolution of normal cells to tumor cells are needed. To produce such cells, we developed the…”
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Development of a neutralization assay for influenza virus using an endpoint assessment based on quantitative reverse-transcription PCR by Teferedegne, Belete, Lewis, Jr, Andrew M, Peden, Keith, Murata, Haruhiko

“…A microneutralization assay using an ELISA-based endpoint assessment (ELISA-MN) is widely used to measure the serological response to influenza virus infection…”
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Roles for CXC Chemokine Ligands 10 and 11 in Recruiting CD4+ T Cells to HIV-1-Infected Monocyte-Derived Macrophages, Dendritic Cells, and Lymph Nodes by Foley, John F, Yu, Cheng-Rong, Solow, Rikki, Yacobucci, Maureen, Peden, Keith W. C, Farber, Joshua M

“…We investigated roles for chemoattractants in dissemination of HIV-1 by examining the induction of T cell-active chemokines in HIV-1-infected human…”
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MicroRNAs as potential biomarkers for VERO cell tumorigenicity by Teferedegne, Belete, Macauley, Juliete, Foseh, Gideon, Dragunsky, Eugenia, Chumakov, Konstantin, Murata, Haruhiko, Peden, Keith, Lewis, Andrew M

“…Abstract MicroRNA expression appears to capture the process of neoplastic development in vitro in the VERO line of African green monkey kidney (AGMK) cells…”
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Mutations in the GM1 Binding Site of Simian Virus 40 VP1 Alter Receptor Usage and Cell Tropism by MAGAIDI, Thomas G, BUCH, Michael H. C, MURATA, Haruhiko, ERICKSON, Kimberly D, NEU, Ursula, GARCEA, Robert L, PEDEN, Keith, STEHLE, Thilo, DIMAIO, Daniel

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Patterns of microRNA expression in non-human primate cells correlate with neoplastic development in vitro by Teferedegne, Belete, Murata, Haruhiko, Quiñones, Mariam, Peden, Keith, Lewis, Andrew M

“…MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression post-transcriptionally. They play a critical role in developmental and…”
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A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc by Sheng-Fowler, Li, Tu, Wei, Fu, Haiqing, Murata, Haruhiko, Lanning, Lynda, Foseh, Gideon, Macauley, Juliete, Blair, Donald, Hughes, Stephen H, Coffin, John M, Lewis, Jr, Andrew M, Peden, Keith

“…As part of safety studies to evaluate the risk of residual cellular DNA in vaccines manufactured in tumorigenic cells, we have been developing in vivo assays…”
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A new SIV co-receptor, STRL33 by Alkhatib, Ghalib, Liao, Fang, Berger, Edward A, Farber, Joshua M, Peden, Keith W. C

“…The identification last year of chemokine receptors as fusion co-factors for HIV-1 has contributed significantly towards understanding HIV transmission and…”
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Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization by Murata, Haruhiko, Omeir, Romelda, Tu, Wei, Lanning, Lynda, Phy, Kathryn, Foseh, Gideon, Lewis, Jr, Andrew M, Peden, Keith

“…Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current tumorigenicity assays can be…”
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Identification of a neutralization epitope in the VP1 capsid protein of SV40 by Murata, Haruhiko, Teferedegne, Belete, Sheng, Li, Lewis, Andrew M, Peden, Keith

“…Abstract Three SV40 escape mutants were identified by selection in the presence of monoclonal antibodies with neutralizing activity. The VP1 amino acid…”
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Apoptosis of Bystander T Cells Induced by Human Immunodeficiency Virus Type 1 with Increased Envelope/Receptor Affinity and Coreceptor Binding Site Exposure by HOLM, Geoffrey H, CHENGSHENG ZHANG, GORRY, Paul R, PEDEN, Keith, SCHOLS, Dominique, DE CLERCQ, Erik, GABUZDA, Dana

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CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection by Zaitseva, Marina B, Lee, Shirley, Rabin, Ronald L, Tiffany, H. Lee, Farber, Joshua M, Peden, Keith W. C, Murphy, Philip M, Golding, Hana

“…Thymocyte infection with HIV-1 is associated with thymic involution and impaired thymopoiesis, particularly in pediatric patients. To define mechanisms of…”
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Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI by Peden, K, Emerman, M, Montagnier, L

“…The construction and preliminary biological characterization of three molecular clones of human immunodeficiency virus type 1 (HIV-1) are reported: HIV-1LAI…”
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Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children by Tuttle, Daniel L, Anders, Cynthia B, Aquino-De Jesus, M Janette, Poole, Paul P, Lamers, Susanna L, Briggs, Daniel R, Pomeroy, Steven M, Alexander, Louis, Peden, Keith W C, Andiman, Warren A, Sleasman, John W, Goodenow, Maureen M

“…Non-syncytium-inducing (NSI) strains of HIV-1 prevail among most infected children, including pediatric patients who develop advanced disease, severe immune…”
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The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization by Emerman, M, Vazeux, R, Peden, K

“…By in situ hybridization analysis and immunoprecipitations following transfection of COS cells, we show that the Rev protein of the human immunodeficiency…”
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Human Immunodeficiency Virus (HIV) gp41 Escape Mutants: Cross-Resistance to Peptide Inhibitors of HIV Fusion and Altered Receptor Activation of gp120 by DESMEZIERES, Emmanuel, GUPTA, Nidhi, VASSELL, Russell, YONG HE, PEDEN, Keith, SIROTA, Lev, ZHONGNING YANG, WINGFIELD, Paul, WEISS, Carol D

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The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: a role for Vif in determining virus host range and cross-species transmission by Simon, James H.M., Miller, David L., Fouchier, Ron A.M., Soares, Marcelo A., Peden, Keith W.C., Malim, Michael H.

“…The primate immunodeficiency virus Vif proteins are essential for replication in appropriate cultured cell systems and, presumably, for the establishment of…”
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Tumors induced in mice by direct inoculation of plasmid DNA expressing both activated H-ras and c-myc by Sheng-Fowler, Li, Cai, Fang, Fu, Haiqing, Zhu, Yong, Orrison, Brian, Foseh, Gideon, Blair, Don G, Hughes, Stephen H, Coffin, John M, Lewis, Jr, Andrew M, Peden, Keith

“…Vaccines contain residual DNA derived from the cells used to produce them. As part of our investigation to assess the risk of this cellular DNA, we are…”
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