Search Results - "Peden, AH"

In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc by Jones, M, Peden, AH, Prowse, CV, Gröner, A, Manson, JC, Turner, ML, Ironside, JW, MacGregor, IR, Head, MW

“…Variant Creutzfeldt-Jakob disease (vCJD) poses a serious risk of secondary transmission and the need to detect infectivity in asymptomatic individuals is…”
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Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient by Peden, Alexander H, Head, Mark W, Diane, L Ritchie, Jeanne, E Bell, James, W Ironside

“…We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-neurological disorder 5 years after receiving a blood…”
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Detection and localization of PrPSc in the skeletal muscle of patients with variant, latrogenic, and sporadic forms of creutzfeldt-jakob disease by PEDEN, Alexander H, RITCHIE, Diane L, HEAD, Mark W, IRONSIDE, James W

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Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2 by Bolger, Graeme B., Peden, Alexander H., Steele, Michael R., MacKenzie, Carolynn, McEwan, David G., Wallace, Derek A., Huston, Elaine, Baillie, George S., Houslay, Miles D.

“…The cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4A5 interacted with the immunophilin XAP2 in a yeast two-hybrid assay. The interaction was…”
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Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay by Jones, Michael, Peden, Alexander H, Wight, Darren, Prowse, Christopher, MacGregor, Ian, Manson, Jean, Turner, Marc, Ironside, James W, Head, Mark W

“…Prion protein type and codon 129 genotype are thought to be major determinants of susceptibility and phenotype in human prion diseases. Using an in-vitro…”
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Detection and Localization of PrP super(Sc) in the Skeletal Muscle of Patients with Variant, Iatrogenic, and Sporadic Forms of Creutzfeldt-Jakob Disease by Peden, AH, Ritchie, D L, Head, M W, Ironside, J W

“…Variant Creutzfeldt-Jakob disease (vCJD) differs from other human prion diseases in that the pathogenic prion protein PrP super(Sc) can be detected to a…”
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BCR kinase phosphorylates 14‐3‐3 Tau on residue 233 by Clokie, Samuel J., Cheung, Kin Y., Mackie, Shaun, Marquez, Rodolfo, Peden, Alex H., Aitken, Alastair

“…The breakpoint cluster region protein, BCR, has protein kinase activity that can auto‐ and trans‐phosphorylate serine, threonine and tyrosine residues. BCR has…”
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Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease by Head, M W, Peden, A H, Yull, H M, Ritchie, D L, Bonshek, R E, Tullo, A B, Ironside, J W

“…Background: Involvement of the eye has been reported in patients with variant Creutzfeldt-Jakob disease (vCJD), but there is disagreement on whether retinal…”
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In vitro amplification and detection of variant Creutzfeldt–Jakob disease PrP Sc by Jones, M, Peden, AH, Prowse, CV, Gröner, A, Manson, JC, Turner, ML, Ironside, JW, MacGregor, IR, Head, MW

“…Abstract Variant Creutzfeldt–Jakob disease (vCJD) poses a serious risk of secondary transmission and the need to detect infectivity in asymptomatic individuals…”
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Disease-associated prion protein is not detectable in human systemic amyloid deposits by Tennent, GA, Head, MW, Bishop, M, Hawkins, PN, Will, RG, Knight, R, Peden, AH, McCardle, LM, Ironside, JW, Pepys, MB

“…Cerebral and cardiac amyloid deposits have been reported after scrapie infection in transgenic mice expressing variant prion protein (PrPC) lacking the…”
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Stimulation of p70S6 Kinase via a Growth Hormone-Controlled Phosphatidylinositol 3-Kinase Pathway Leads to the Activation of a PDE4A Cyclic AMP-Specific Phosphodiesterase in 3T3-F442A Preadipocytes by MacKenzie, Simon J., Yarwood, Stephen J., Peden, Alexander H., Bolger, Graeme B., Vernon, Richard G., Houslay, Miles D.

“…The challenge of 3T3-F442A fibroblasts with growth hormone led to both a decrease in the mobility on SDS/PAGE and activation of the PDE4A cyclic AMP-specific…”
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Risks of transmission of variant Creutzfeldt-Jakob disease by blood transfusion by Peden, Alexander H, Ritchie, Diane L, Ironside, James W

“…Variant Creutzfeldt-Jakob disease (vCJD) was first identified in 1996 in the UK, and results from human exposure to the bovine spongiform encephalopathy (BSE)…”
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TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca super(2+)-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid by Baillie, G S, Huston, E, Scotland, G, Hodgkin, M, Gall, I, Peden, AH, MacKenzie, C, Houslay, E S, Currie, R, Pettitt, T R, Walmsley, A R, Wakelam, MJO, Warwicker, J, Houslay, MD

“…Here we identify an 11-residue helical module in the unique N-terminal region of the cyclic AMP-specific phosphodiesterase PDE4A1 that determines association…”
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Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient by Peden, AH, Head, M W, Ritchie, D L, Bell, JE, Ironside, J W

“…We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-neurological disorder 5 years after receiving a blood…”
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Intracellular Compartmentalization of PDE4 Cyclic AMP-Specific Phosphodiesterases by Scotland, G., Beard, M., Erdogan, S., Huston, E., McCallum, F., MacKenzie, S.J., Peden, A.H., Pooley, L., Rena, N.G., Ross, A.H., Yarwood, S.J., Houslay, M.D.

“…The PDE4 cyclic AMP-specific phosphodiesterase family comprises a large number of different isoforms encoded by four distinct genes, with additional complexity…”
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