Search Results - "Peculis, Brenda A."

Effects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells by Song, Hailong, Lu, Yuan, Qu, Zhe, Mossine, Valeri V., Martin, Matthew B., Hou, Jie, Cui, Jiankun, Peculis, Brenda A., Mawhinney, Thomas P., Cheng, Jianlin, Greenlief, C. Michael, Fritsche, Kevin, Schmidt, Francis J., Walter, Ronald B., Lubahn, Dennis B., Sun, Grace Y., Gu, Zezong

“…Aged garlic extract (AGE) is widely used as a dietary supplement on account of its protective effects against oxidative stress and inflammation. But less is…”
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Metal Determines Efficiency and Substrate Specificity of the Nuclear NUDIX Decapping Proteins X29 and H29K (Nudt16) by Peculis, Brenda A., Reynolds, Kristen, Cleland, Megan

“…The Xenopus X29 protein was identified by its high affinity binding to U8 small nucleolar RNA, a small nucleolar RNA required for ribosome biogenesis. X29 and…”
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Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin by Padilla, Philip Ian, Uhart, Marina, Pacheco-Rodriguez, Gustavo, Peculis, Brenda A, Moss, Joel, Vaughan, Martha

“…BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, activates class I ADP-ribosylation factors (ARF1-3) by catalyzing the replacement of bound…”
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Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme by Taylor, Melissa J, Peculis, Brenda A

“…Nudt16p is a nuclear RNA decapping protein initially identified in Xenopus (X29) and known to exist in mammals. Here, we identified putative orthologs in 57…”
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Xenopus LSm Proteins Bind U8 snoRNA via an Internal Evolutionarily Conserved Octamer Sequence by Tomasevic, Nenad, Peculis, Brenda A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Xenopus U8 snoRNA Binding Protein Is a Conserved Nuclear Decapping Enzyme by Ghosh, Trina, Peterson, Brian, Tomasevic, Nenad, Peculis, Brenda A

“…U8 snoRNP is required for accumulation of mature 5.8S and 28S rRNA in vertebrates. We are identifying proteins that bind U8 RNA with high specificity to…”
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Dynamic conformational model for the role of ITS2 in pre-rRNA processing in yeast by CÔTÉ, COLETTE A., GREER, CHRIS L., PECULIS, BRENDA A.

“…Maturation of the large subunit rRNAs includes a series of cleavages that result in removal of the internal transcribed spacer (ITS2) that separates mature…”
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Two Ps in the bacterial pod by Peculis, Brenda A

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A Proinsulin Gene Splice Variant with Increased Translation Efficiency Is Expressed in Human Pancreatic Islets by Shalev, Anath, Blair, Patrick J, Hoffmann, Steven C, Hirshberg, Boaz, Peculis, Brenda A, Harlan, David M

“…As glucose-induced insulin expression is mainly regulated at the translational level, and such regulation often involves the 5′-untranslated region (5′UTR), we…”
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Crystal Structures of U8 snoRNA Decapping Nudix Hydrolase, X29, and Its Metal and Cap Complexes by Scarsdale, J. Neel, Peculis, Brenda A., Wright, H. Tonie

“…X29, a 25 kDa Nudix hydrolase from Xenopus laevis that cleaves 5′ caps from U8 snoRNA, crystallizes as a homodimeric apoenzyme. Manganese binds crystals of…”
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Ribosome Biogenesis: Ribosomal RNA Synthesis as a Package Deal by Peculis, Brenda A

“…Ribosome biogenesis encompasses a complicated series of events involving hundreds of transiently interacting components. Insight into a mechanism for…”
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The sequence of the 5' end of the U8 small nucleolar RNA is critical for 5.8S and 28S rRNA maturation by Peculis, Brenda A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast by Côté, C A, Peculis, B A

“…Eucaryotic ribosome biogenesis involves many cis-acting sequences and trans-acting factors, including snoRNAS: We have used directed mutagenesis of rDNA…”
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Increased Insulin Translation from an Insulin Splice-Variant Overexpressed in Diabetes, Obesity, and Insulin Resistance by Minn, Alexandra H, Lan, Hong, Rabaglia, Mary E, Harlan, David M, Peculis, Brenda A, Attie, Alan D, Shalev, Anath

“…Type 2 diabetes occurs when pancreatic β-cells become unable to compensate for the underlying insulin resistance. Insulin secretion requires β-cell insulin…”
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Disruption of U8 nucleolar snRNA inhibits 5.8S and 28S rRNA processing in the Xenopus oocyte by Peculis, B A, Steitz, J A

“…The nucleoli of vertebrate cells contain several snRNPs, of which only one, U3, has been assigned a role in rRNA processing. We present the primary sequence of…”
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RNA-binding proteins: If it looks like a sn(o)RNA by Peculis, Brenda A

“…Small nuclear RNAs are involved in splicing pre-mRNA, while small nucleolar RNAs facilitate ribosome biogenesis. But these distinct particles may have more in…”
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Crystals of X29, a Xenopus laevis U8 snoRNA-binding protein with nuclear decapping activity by Peculis, Brenda A., Scarsdale, J. Neel, Wright, H. T.

“…Eukaryotic ribosome biosynthesis requires modification (methylation, pseudouridylation) and nucleolytic processing of precursor ribosomal RNAs in the…”
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The U8 snoRNA gene family: identification and characterization of distinct, functional U8 genes in Xenopus by Peculis, Brenda A, DeGregorio, Suzanne, McDowell, Kathi

“…U8 snoRNA is the RNA component of a small nucleolar ribonucleoprotein (U8 snoRNP) required for accumulation of mature 5.8S and 28S rRNAs, components of the…”
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Localization of the Nucleolar Protein NO38 in Amphibian Oocytes by Peculis, Brenda A., Gall, Joseph G.

“…To examine the role of primary amino acid sequence in the localization of proteins within the nucleus, we studied the nucleolar protein NO38 of amphibian…”
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A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets by Shalev, Anath, Blair, Patrick J, Hoffmann, Steven C, Hirshberg, Boaz, Peculis, Brenda A, Harlan, David M

“…As glucose-induced insulin expression is mainly regulated at the translational level, and such regulation often involves the 5'-untranslated region (5'UTR), we…”
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