Search Results - "Pecker, I"

Heparanase as mediator of angiogenesis: mode of action by Elkin, Michael, Ilan, Neta, Ishai-Michaeli, Rivka, Friedmann, Yael, Papo, Orit, Pecker, Iris, Vlodavsky, Israel

“…ABSTRACT Extracellular matrix (ECM) and basement membranes (BMs) present a physical barrier that requires enzymatic degradation during endothelial cell (EC)…”
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Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening by Pecker, I, Gabbay, R, Cunningham, Jr, F X, Hirschberg, J

“…The cDNA which encodes lycopene cyclase, CrtL, was cloned from tomato (Lycopersicon esculentum cv. VF36) and tobacco (Nicotiana tabacum cv. Samsun NN) and…”
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A single polypeptide catalyzing the conversion of phytoene to zeta-carotene is transcriptionally regulated during tomato fruit ripening by Pecker, I. (The Hebrew University of Jerusalem, Jerusalem, Israel), Chamovitz, D, Linden, H, Sandmann, G, Hirschberg, J

“…The cDNA of the gene pds from tomato, encoding the carotenoid biosynthesis enzyme phytoene desaturase, was cloned, and its nucleotide sequence was determined…”
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Molecular genetics of the carotenoid biosynthesis pathway in plants and algae by Hirschberg, Joseph, Cohen, M., Harker, Mark, Lotan, Tamar, Mann, Varda, Pecker, I.

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The molecular basis of resistance to the herbicide norflurazon by Chamovitz, D. (Hebrew Univ. of Jerusalem (Israel). Dept. of Genetics), Pecker, I, Hirschberg, J

“…We have cloned and sequenced a gene, pds, from the cyanobacterium Synechococcus PCC7942 that is responsible for resistance to the bleaching herbicide…”
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Mammalian heparanase as mediator of tumor metastasis and angiogenesis by Vlodavsky, I, Elkin, M, Pappo, O, Aingorn, H, Atzmon, R, Ishai-Michaeli, R, Aviv, A, Pecker, I, Friedmann, Y

“…Expression of heparan sulfate-degrading endoglycosidases, commonly referred to as heparanases, correlates with the metastatic potential of tumor cell lines,…”
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Molecular cloning and expression in photosynthetic bacteria of a soybean cDNA coding for phytoene desaturase, an enzyme of the carotenoid biosynthesis pathway by Bartley, G.E. (Du Pont Central Research and Development, Wilmington, DE), Viitanen, P.V, Pecker, I, Chamovitz, D, Hirschberg, J, Scolnik, P.A

“…Carotendoids are orange, yellow, or red photoprotective pigments present in all plastids. The first carotenoid of the pathway is phytoene, a colorless compound…”
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Identification and Chromosomal Localization of Atm, the Mouse Homolog of the Ataxia–Telangiectasia Gene by Pecker, Iris, Avraham, Karen B., Gilbert, Debra J., Savitsky, Kinneret, Rotman, Galit, Harnik, Reli, Fukao, Toshiyuki, Schröck, Evelin, Hirotsune, Shinji, Tagle, Danilo A., Collins, Francis.S., Wynshaw-Boris, Anthony, Ried, Thomas, Copeland, Neal G., Jenkins, Neal A., Shiloh, Yosef, Ziv, Yael

“…Atm, the mouse homolog of the human ATM gene defective in ataxia–telangiectasia (A–T), has been identified. The entire coding sequence of the Atm transcript…”
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Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis by Vlodavsky, Israel, Friedmann, Yael, Elkin, Michael, Aingorn, Helena, Atzmon, Ruth, Ishai-Michaeli, Rivka, Bitan, Menachem, Pappo, Orit, Peretz, Tuvia, Michal, Israel, Spector, Larissa, Pecker, Iris

“…Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth factors and enzymes. Degradation of heparan sulfate by…”
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Metabolic engineering of astaxanthin production in tobacco flowers by Hirschberg, Joseph, Mann, Varda, Harker, Mark, Pecker, Iris

“…Using metabolic engineering, we have modified the carotenoid biosynthesis pathway in tobacco (Nicotiana tabacum) to produce astaxanthin, a red pigment of…”
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Heparanase expression in primary and metastatic pancreatic cancer by KOLIOPANOS, Alexander, FRIESS, Helmut, KLEEFF, Jörg, XIN SHI, QUAN LIAO, PECKER, Iris, VLODAVSKY, Israel, ZIMMERMANN, Arthur, BÜCHLER, Markus W

“…The human endoglycosidase heparanase (hpa) degrades heparan-sulfate proteoglycans, which constitute prominent components of basement membranes and…”
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Expression of Heparanase in Normal, Dysplastic, and Neoplastic Human Colonic Mucosa and Stroma : Evidence for Its Role in Colonic Tumorigenesis by Friedmann, Yael, Vlodavsky, Israel, Aingorn, Helena, Aviv, Ayelet, Peretz, Tuvia, Pecker, Iris, Pappo, Orit

“…The human heparanase gene, an endo-beta-glucuronidase that cleaves heparan sulfate at specific intrachain sites, has recently been cloned and shown to function…”
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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase by Savitsky, Kinneret, Bar-Shira, Anat, Gilad, Shlomit, Rotman, Galit, Ziv, Yael, Vanagaite, Lina, Tagle, Danilo A., Smith, Sara, Uziel, Tamar, Sfez, Sharon, Ashkenazi, Maya, Pecker, Iris, Frydman, Moshe, Harnik, Reli, Patanjali, Sankhavaram R., Simmons, Andrew, Clines, Gregory A., Sartiel, Adam, Gatti, Richard A., Chessa, Luciana, Sanal, Ozden, Lavin, Martin F., Jaspers, N. G. J., A. Malcolm R. Taylor, Arlett, Colin F., Miki, Toru, Weissman, Sherman M., Lovett, Michael, Collins, Francis S., Shiloh, Yosef

“…A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is…”
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Recombinant ATM protein complements the cellular A-T phenotype by ZIV, Y, BAR-SHIRA, A, PECKER, I, RUSSELL, P, JORGENSEN, T. J, TSARFATI, I, SHILOH, Y

“…Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by neurodegeneration, immunodeficiency, cancer predisposition, genome instability…”
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Expression Pattern and Secretion of Human and Chicken Heparanase Are Determined by Their Signal Peptide Sequence by Goldshmidt, O, Zcharia, E, Aingorn, H, Guatta-Rangini, Z, Atzmon, R, Michal, I, Pecker, I, Mitrani, E, Vlodavsky, I

“…Cleavage of heparan sulfate (HS) proteoglycans affects the integrity and function of tissues and thereby fundamental phenomena, involving cell migration and…”
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Heparanase expression in human leukemias is restricted to acute myeloid leukemias by Bitan, Menachem, Polliack, Aaron, Zecchina, Gabriella, Nagler, Arnon, Friedmann, Yael, Nadav, Liat, Deutsch, Varda, Pecker, Iris, Eldor, Amiram, Vlodavsky, Israel, Katz, Ben-Zion

“…Matrix metalloproteinases and an endo-β-D-glucuronidase (heparanase) are enzymes that degrade the protein and carbohydrate constituents of basement membranes,…”
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Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis by Zcharia, E, Metzger, S, Chajek-Shaul, T, Friedmann, Y, Pappo, O, Aviv, A, Elkin, M, Pecker, I, Peretz, T, Vlodavsky, I

“…Tumor spread involves degradation of various components of the extracellular matrix and blood vessel wall. Among these is heparan sulfate proteoglycan, which…”
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Functional Complementation in Escherichia coli of Different Phytoene Desaturase Genes and Analysis of Accumulated Carotenes by Linden, Hartmut, Misawa, Norihiko, Chamovitz, Daniel, Pecker, Iris, Hirschberg, Joseph, Sandmann, Gerhard

“…Three different phytoene desaturase genes, from Rhodobacter capsulatus, Erwinia uredovora, and Synechococcus PCC 7942, have been functionally complemented with…”
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Cloning and characterization of the gene for phytoene desaturase (Pds) from tomato (Lycopersicon esculentum) by Mann, V. (Hebrew Univ. of Jerusalem (Israel). Dept. of Genetics), Pecker, I, Hirschberg, J

“…The gene Pds encodes phytoene desaturase, a key enzyme in carotenoid biosynthesis that converts phytoene to zeta-carotene. We have cloned and analyzed the…”
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Molecular cloning and expression in photosythetic bacteria of a soybean cDNA coding for phytoene desaturase, an enzyme of the carotenoid biosynthesis pathway by BARTLEY, G. E, VITANEN, P. V, PECKER, I, CHAMOVITZ, D, HIRSCHBERG, J, SCOLNIK, P. A

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