Search Results - "Peck, Michael W"
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Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
Published in Research in microbiology (01-05-2015)“…Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of Clostridium…”
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Biology and genomic analysis of Clostridium botulinum
Published in Advances in microbial physiology (2009)“…The ability to form botulinum neurotoxin is restricted to six phylogenetically and physiologically distinct bacteria (Clostridium botulinum Groups I-IV and…”
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Identification of a novel botulinum neurotoxin gene cluster in Enterococcus
Published in FEBS letters (01-02-2018)“…The deadly neurotoxins of Clostridium botulinum (BoNTs) comprise eight serotypes (A–G; X). The neurotoxin gene cluster encoding BoNT and its accessory proteins…”
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Risk presented to minimally processed chilled foods by psychrotrophic Bacillus cereus
Published in Trends in food science & technology (01-11-2019)“…Spores of psychrotrophic Bacillus cereus may survive the mild heat treatments given to minimally processed chilled foods. Subsequent germination and cell…”
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Lag Phase Is a Distinct Growth Phase That Prepares Bacteria for Exponential Growth and Involves Transient Metal Accumulation
Published in Journal of Bacteriology (01-02-2012)“…Lag phase represents the earliest and most poorly understood stage of the bacterial growth cycle. We developed a reproducible experimental system and conducted…”
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Diversity of the Genomes and Neurotoxins of Strains of Clostridium botulinum Group I and Clostridium sporogenes Associated with Foodborne, Infant and Wound Botulism
Published in Toxins (11-09-2020)“…Group I and are closely related bacteria responsible for foodborne, infant and wound botulism. A comparative genomic study with 556 highly diverse strains of…”
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Pan-Genomic Analysis of Clostridium botulinum Group II (Non-Proteolytic C. botulinum ) Associated with Foodborne Botulism and Isolated from the Environment
Published in Toxins (08-05-2020)“…The neurotoxin formed by Group II is a major cause of foodborne botulism, a deadly intoxication. This study aims to understand the genetic diversity and spread…”
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Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteolytic Clostridium botulinum
Published in Applied and Environmental Microbiology (01-07-2010)“…A significant number of genome sequences of Clostridium botulinum and related species have now been determined. In silico analysis of these data revealed the…”
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Analysis of the Germination of Individual Clostridium sporogenes Spores with and without Germinant Receptors and Cortex-Lytic Enzymes
Published in Frontiers in microbiology (25-10-2017)“…The Gram-positive spore-forming anaerobe is a significant cause of food spoilage, and it is also used as a surrogate for spores for testing the efficacy of…”
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Functional characterisation of germinant receptors in Clostridium botulinum and Clostridium sporogenes presents novel insights into spore germination systems
Published in PLoS pathogens (01-09-2014)“…Clostridium botulinum is a dangerous pathogen that forms the highly potent botulinum toxin, which when ingested causes a deadly neuroparalytic disease. The…”
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The orphan germinant receptor protein GerXAO (but not GerX3b) is essential for L-alanine induced germination in Clostridium botulinum Group II
Published in Scientific reports (04-05-2018)“…Clostridium botulinum is an anaerobic spore forming bacterium that produces the potent botulinum neurotoxin that causes a severe and fatal neuro-paralytic…”
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Impact of Clostridium botulinum genomic diversity on food safety
Published in Current opinion in food science (01-08-2016)“…•C. botulinum Groups I and II form botulinum neurotoxin and cause foodborne botulism.•Increased knowledge of C. botulinum Group I and II genomes and neurotoxin…”
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Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum
Published in BMC genomics (19-03-2009)“…Proteolytic Clostridium botulinum is the causative agent of botulism, a severe neuroparalytic illness. Given the severity of botulism, surprisingly little is…”
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Contrasting Effects of Heat Treatment and Incubation Temperature on Germination and Outgrowth of Individual Spores of Nonproteolytic Clostridium botulinum Bacteria
Published in Applied and Environmental Microbiology (01-05-2009)“…In this study, we determined the effects of incubation temperature and prior heat treatment on the lag-phase kinetics of individual spores of nonproteolytic…”
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Multiplex PCR for Detection of Botulinum Neurotoxin-Producing Clostridia in Clinical, Food, and Environmental Samples
Published in Applied and Environmental Microbiology (01-10-2009)“…Botulinum neurotoxin (BoNT), the most toxic substance known, is produced by the spore-forming bacterium Clostridium botulinum and, in rare cases, also by some…”
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Diversity of the Germination Apparatus in Clostridium botulinum Groups I, II, III, and IV
Published in Frontiers in microbiology (28-10-2016)“…is a highly dangerous pathogen that forms very resistant endospores that are ubiquitous in the environment, and which, under favorable conditions germinate to…”
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An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production
Published in PLoS computational biology (01-11-2016)“…Clostridium botulinum produces botulinum neurotoxins (BoNTs), highly potent substances responsible for botulism. Currently, mathematical models of C. botulinum…”
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Rapid Affinity Immunochromatography Column-Based Tests for Sensitive Detection of Clostridium botulinum Neurotoxins and Escherichia coli O157
Published in Applied and Environmental Microbiology (01-07-2010)“…Existing methods for detection of food-borne pathogens and their toxins are frequently time-consuming, require specialized equipment, and involve lengthy…”
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Complete Genome Sequence of the Proteolytic Clostridium botulinum Type A5 (B3′) Strain H04402 065
Published in Journal of Bacteriology (01-05-2011)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Development and Application of a New Method for Specific and Sensitive Enumeration of Spores of Nonproteolytic Clostridium botulinum Types B, E, and F in Foods and Food Materials
Published in Applied and Environmental Microbiology (01-10-2010)“…The highly potent botulinum neurotoxins are responsible for botulism, a severe neuroparalytic disease. Strains of nonproteolytic Clostridium botulinum form…”
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