Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia

We estimated the frequency of CYP1A1, CYP1A2, CYP1B1, CYP19, and SULT1A1 allelic variants in a female population of the Novosibirsk district and their association with the elevated risk of breast (BC), ovarian (OC), and endometrial (EC) cancers. Significant differences (OR = 2.34, p = 0.0002) in the...

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Bibliographic Details
Published in:	Advances in experimental medicine and biology Vol. 617; p. 359
Main Authors:	Gulyaeva, Lyudmila F, Mikhailova, Olga N, PustyInyak, Vladimir O, Kim, 4th, Inessa V, Gerasimov, Alexei V, Krasilnikov, Sergey E, Filipenko, Maxim L, Pechkovsky, Eugene V
Format:	Journal Article
Language:	English
Published:	United States 2008
Subjects:	Aromatase - genetics Aryl Hydrocarbon Hydroxylases Arylsulfotransferase - genetics Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Case-Control Studies Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System - genetics Endometrial Neoplasms - enzymology Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Estrogens - metabolism Female Genotype Humans Middle Aged Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Russia Russia
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Summary:	We estimated the frequency of CYP1A1, CYP1A2, CYP1B1, CYP19, and SULT1A1 allelic variants in a female population of the Novosibirsk district and their association with the elevated risk of breast (BC), ovarian (OC), and endometrial (EC) cancers. Significant differences (OR = 2.34, p = 0.0002) in the allele distributions for CYP1A1 M1 polymorphism between patients with BC (n = 118) and controls (n = 180) were found. No significant difference in both genotype and allele distributions for CYP1A1 polymorphisms in patients with OC (n = 96) and EC (n = 154) was observed. Remarkable differences in the allele and genotype distributions for CYP1A21F polymorphism in patients with BC or OC were found (OR = 0.26, p = 0.0000005 and OR = 0.34, p = 0.00000002). There were no differences for this polymorphism in women with EC. In patients with BC no significant differences were found in genotype and allele distributions for R264C polymorphism in the CYP19 gene. The frequency of a mutant CYP19 heterozygote genotype C/T was higher in patients with OC and EC compared with healthy women (OR = 3.87, p = 0.001 and OR = 3.73, p = 0.0004, respectively). Comparison of allele frequencies revealed a deficiency of an allele A of SULT1A12 in patients with OC (OR = 0.64, p = 0.019) compared with controls. No differences were found in the genotype and allele distributions for SULT1A1 polymorphism between patients with BC and EC and controls. In addition, there were no difference in allele and genotype distributions for CYP1B1 119G-->T polymorphism between BC and control. In conclusion, these results support the hypothesis that susceptibility gene alleles of estrogen-metabolizing enzymes may differentially influence risk for woman hormone-dependent cancers.
ISSN:	0065-2598
DOI:	10.1007/978-0-387-69080-3_34