Search Results - "Pechan, Peter"

Inhibition of Choroidal Neovascularization in a Nonhuman Primate Model by Intravitreal Administration of an AAV2 Vector Expressing a Novel Anti-VEGF Molecule by Lukason, Michael, DuFresne, Elizabeth, Rubin, Hillard, Pechan, Peter, Li, Qiuhong, Kim, Ivana, Kiss, Szilard, Flaxel, Christina, Collins, Margaret, Miller, Joan, Hauswirth, William, MacLachlan, Timothy, Wadsworth, Samuel, Scaria, Abraham

“…Inhibition of vascular endothelial growth factor (VEGF) for the management of the pathological ocular neovascularization associated with diseases such as…”
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Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo by JACOBS, Andreas, TJUVAJEV, Juri G, PECHAN, Peter A, CHIOCCA, E. Antonio, BREAKEFIELD, Xandra O, BLASBERG, Ronald G, DUBROVIN, Michael, AKHURST, Timothy, BALATONI, Julius, BEATTI, Bradley, JOSHI, Revathi, FINN, Ronald, LARSON, Steven M, HERRLINGER, Ulrich

“…To evaluate the efficiency of gene delivery in gene therapy strategies for malignant brain tumors, it is important to determine the distribution and magnitude…”
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Aurintricarboxylic acid increases yield of HSV-1 vectors by Pechan, Peter, Ardinger, Jeffery, Ketavarapu, Jyothi, Rubin, Hillard, Wadsworth, Samuel C, Scaria, Abraham

“…Production of large quantities of viral vectors is crucial for the success of gene therapy in the clinic. There is a need for higher titers of herpes simplex…”
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Generation of an Adenovirus Vector Lacking E1, E2a, E3, and All of E4 except Open Reading Frame 3 by Gorziglia, M I, Lapcevich, C, Roy, S, Kang, Q, Kadan, M, Wu, V, Pechan, P, Kaleko, M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms by Rainov, N G, Ikeda, K, Qureshi, N H, Grover, S, Herrlinger, U, Pechan, P, Chiocca, E A, Breakefield, X O, Barnett, F H

“…This study investigated the intraarterial delivery of genetically engineered replication-deficient adenovirus vectors (AVs) and cationic liposome-plasmid DNA…”
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Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing by Selvaraj, Nagarathinam, Wang, Chao-Kuei, Bowser, Brian, Broadt, Trevor, Shaban, Samir, Burns, Jenna, Saptharishi, Nirmala, Pechan, Peter, Golebiowski, Diane, Alimardanov, Asaf, Yang, Nora, Mitra, George, Vepachedu, Ramarao

“…Recombinant adeno-associated viral (rAAV) vector-based gene therapy has been adapted for use in more than 100 clinical trials. This is mainly because of its…”
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Free radicals induce gene expression of NGF and bFGF in rat astrocyte culture by Pechan, P A, Chowdhury, K, Seifert, W

“…Hydrogen peroxide (H2O2) is a type of active oxygen species produced mainly in blood by inflammation, ischemia or anoxia. Treatment of rat neonatal cortical…”
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Gene Therapies for Neovascular Age-Related Macular Degeneration by Pechan, Peter, Wadsworth, Samuel, Scaria, Abraham

“…Pathological neovascularization is a key component of the neovascular form (also known as the wet form) of age-related macular degeneration (AMD) and…”
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Genetically modified fibroblasts producing NGF protect hippocampal neurons after ischemia in the rat by Pechan, P A, Yoshida, T, Panahian, N, Moskowitz, M A, Breakefield, X O

“…The neuroprotective effect of nerve growth factor (NGF) on the pyramidal cells in the vulnerable CA1-CA2 sectors of the hippocampus was investigated in a rat…”
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HSV-1 infected cell proteins influence tetracycline-regulated transgene expression by Herrlinger, Ulrich, Pechan, Peter A., Jacobs, Andreas H., Woiciechowski, Christian, Rainov, Nikolai G., Fraefel, Cornel, Paulus, Werner, Reeves, Steven A.

“…Background This study investigates elements of herpes simplex virus type 1 (HSV‐1) which influence transgene expression in tetracycline‐regulated expression…”
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Combined HSV-1 recombinant and amplicon piggyback vectors: replication-competent and defective forms, and therapeutic efficacy for experimental gliomas by Pechan, Peter A., Herrlinger, Ulrich, Aghi, Manish, Jacobs, Andreas, Breakefield, Xandra O.

“…Background The versatility of HSV‐1 vectors includes large transgene capacity, selective replication of mutants in dividing cells, and availability of…”
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bFGF induces its own gene expression in astrocytic and hippocampal cell cultures by Flott-Rahmel, B, Gerdes, W, Pechan, P A, Brysch, W, Schlingensiepen, K H, Seifert, W

“…Basic FGF mRNA induction by bFGF was investigated in cell cultures from rat brain, i.e. postnatal day 2 cortex and embryonic day 18 hippocampus. In situ…”
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Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1 by Shen, F, Mao, L, Zhu, W, Lawton, M T, Pechan, P, Colosi, P, Wu, Z, Scaria, A, Su, H

“…The soluble vascular endothelial growth factor (VEGF) receptor 1 (sFLT1) has been tested in both animals and humans for anti-angiogenic therapies, for example,…”
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sFLT01: a novel fusion protein with antiangiogenic activity by Bagley, Rebecca G, Kurtzberg, Leslie, Weber, William, Nguyen, Tri-Hung, Roth, Stephanie, Krumbholz, Roy, Yao, Min, Richards, Brenda, Zhang, Mindy, Pechan, Peter, Schmid, Steve, Scaria, Abraham, Kaplan, Johanne, Teicher, Beverly A

“…sFLT01 is a novel fusion protein that consists of the VEGF/PlGF (placental growth factor) binding domain of human VEGFR1/Flt-1 (hVEGFR1) fused to the Fc…”
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AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2−/− /Cx3cr1−/− mice by Tuo, Jingsheng, Pang, Ji-Jing, Cao, Xiaoguang, Shen, Defen, Zhang, Jun, Scaria, Abraham, Wadsworth, Samuel C, Pechan, Peter, Boye, Sanford L, Hauswirth, William W, Chan, Chi-Chao

“…Abstract To test the effects of adeno-associated virus encoding sFLT01 (AAV5.sFLT01) on the retinal lesions in Ccl2 −/− /Cx3cr1 −/− mice, a model for…”
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AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2 super(-/-)/Cx3cr1 super(-/-) mice by Tuo, Jingsheng, Pang, Ji-Jing, Cao, Xiaoguang, Shen, Defen, Zhang, Jun, Scaria, Abraham, Wadsworth, Samuel C, Pechan, Peter, Boye, Sanford L, Hauswirth, William W, Chan, Chi-Chao

“…To test the effects of adeno-associated virus encoding sFLT01 (AAV5.sFLT01) on the retinal lesions in Ccl2 super(-/-)/Cx3cr1 super(-/-) mice, a model for…”
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AAV‐mediated sFLT‐1 gene therapy ameliorates retinal lesions in Ccl2/Cx3cr1 deficient mice by Tuo, Jingsheng, Pang, Ji‐Jing, Cao, XiaoGuang, Shen, Defen, Zhang, Jun, Scaria, Abraham, Wadsworth, Samuel C, Pechan, Peter, Hauswirth, William W, Chan, Chi‐Chao

“…To test the effect of subretinal delivery of adeno‐associated virus (AAV)‐sFLT‐1 (soluble VEGF receptor‐1) on retinal lesion in ccl2−/−/cx3cr1−/− mice, a…”
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Abstract A14: sFLT01: An antiangiogenic protein that neutralizes placental growth factor by Bagley, Rebecca G., Kurtzberg, Leslie, Weber, William, Nguyen, Tri-Hung, Lovewell, Gwen, Nguyen, Cokey, Yao, Min, Roth, Stephanie, Krumbholz, Roy, Crawford, Jennifer, Pechan, Peter, Shankara, Srinivas, Scaria, Abraham, Schmid, Steve, Brondyk, Bill, Kaplan, Johanne, Teicher, Beverly A.

“…Abstract Introduction: Anti-angiogenic agents have shown clinical value in combination with chemotherapy by targeting the VEGF pathways. The development of…”
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HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells by Johnston, K M, Jacoby, D, Pechan, P A, Fraefel, C, Borghesani, P, Schuback, D, Dunn, R J, Smith, F I, Breakefield, X O

“…Novel hybrid vectors, which incorporate critical elements of both herpes simplex virus type 1 (HSV-1) amplicon vectors and adeno-associated virus (AAV)…”
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503. A Novel Herpes Simplex Virus Helper Based Production of Adeno-Associated Virus Vectors for Treatment of Retinal Angiogenesis by Ye, Guo-jie, Drogemuller, Chris, Thomas, Darby, Scotti, Marina, Kang, Wen, Knop, David, Boye, Sanford, Pechan, Peter, Peterson, James, Hauswirth, William, Scaria, Abraham, Wadsworth, Samuel

“…AGTC's proprietary rAAV vector production method uses recombinant herpes simplex virus (HSV) as the helper agent for rAAV production. This production method…”
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