Search Results - "Pech, Nancy K."

Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice by Xue, Xingkui, Pech, Nancy K., Shelley, W. Christopher, Srour, Edward F., Yoder, Mervin C., Dinauer, Mary C.

“…Inherited hematologic defects that lack an in vivo selective advantage following gene correction may benefit from effective yet minimally toxic cytoreduction…”
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NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages by Bagaitkar, Juhi, Huang, Jing, Zeng, Melody Yue, Pech, Nancy K., Monlish, Darlene A., Perez-Zapata, Lizet J., Miralda, Irina, Schuettpelz, Laura G., Dinauer, Mary C.

“…The phagocyte reduced NAD phosphate (NADPH) oxidase generates superoxide, the precursor to reactive oxygen species (ROS) that has both antimicrobial and…”
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NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis by Bagaitkar, Juhi, Pech, Nancy K., Ivanov, Stoyan, Austin, Anthony, Zeng, Melody Yue, Pallat, Sabine, Huang, Guangming, Randolph, Gwendalyn J., Dinauer, Mary C.

“…The leukocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase generates reactive oxygen species essential in microbial killing and regulation of…”
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A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications by Goebel, W. Scott, Pech, Nancy K., Meyers, Justin L., Srour, Edward F., Yoder, Mervin C., Dinauer, Mary C.

“…Nonmyeloablative conditioning regimens for marrow transplantation are desirable in many settings. Because repeated doses of the antimetabolite 5-fluorouracil…”
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From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease by Stein, Stefan, Scholz, Simone, Schwäble, Joachim, Sadat, Mohammed A, Modlich, Ute, Schultze-Strasser, Stephan, Diaz, Margarita, Chen-Wichmann, Linping, Müller-Kuller, Uta, Brendel, Christian, Fronza, Raffaele, Kaufmann, Kerstin B, Naundorf, Sonja, Pech, Nancy K, Travers, Jeffrey B, Matute, Juan D, Presson, Jr, Robert G, Sandusky, George E, Kunkel, Hana, Rudolf, Eva, Dillmann, Adelina, von Kalle, Christof, Kühlcke, Klaus, Baum, Christopher, Schambach, Axel, Dinauer, Mary C, Schmidt, Manfred, Grez, Manuel

“…Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by impaired antimicrobial activity in phagocytic cells. As a monogenic disease…”
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Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease by Goebel, W. Scott, Pech, Nancy K., Dinauer, Mary C.

“…We previously demonstrated that low-dose radiation conditioning impairs murine hematopoietic stem cell function, permitting engraftment of syngeneic fresh and…”
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Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: Effects of a retroviral-mediated gene transfer protocol and implications for gene therapy by Goebel, W.Scott, Yoder, Mervin C, Pech, Nancy K, Dinauer, Mary C

“…We investigated low-dose radiation conditioning for the transplantation of retrovirus-transduced cells in a C57Bl6/J murine model. The effect of low-dose…”
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Granulocyte Colony-Stimulating Factor Prior to Low-Dose Total Body Irradiation as Conditioning Regimen in Hematopoietic Stem Cell Transplantation for Gene Therapy by Barese, Cecilia N., Goebel, W. Scott, Pech, Nancy K., Meyers, Justin, Dinauer, Mary C.

“…Genetic blood diseases can potentially be treated by transplantation of autologous hematopoietic stem cells (HSC) transduced with the functional gene…”
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Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning by Goebel, W.Scott, Yoder, Mervin C, Pech, Nancy K, Dinauer, Mary C

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