Search Results - "Peart, Jason"

Biomarkers for the identification of cardiac fibroblast and myofibroblast cells by Tarbit, Emiri, Singh, Indu, Peart, Jason N., Rose’Meyer, Roselyn B.

“…Experimental research has recognized the importance of cardiac fibroblast and myofibroblast cells in heart repair and function. In a normal healthy heart, the…”
Get full text

Calcium dynamically alters erythrocyte mechanical response to shear by Kuck, Lennart, Peart, Jason N., Simmonds, Michael J.

“…Red blood cells (RBC) are constantly exposed to varying mechanical forces while traversing the cardiovascular system. Upon exposure to mechanical stimuli…”
Get full text

Cardiovascular adenosine receptors: expression, actions and interactions by Headrick, John P, Ashton, Kevin J, Rose'meyer, Roselyn B, Peart, Jason N

“…Intra- and extracellular adenosine levels rise in response to physiological stimuli and with metabolic/energetic perturbations, inflammatory challenge and…”
Get full text

Trimethylamine N-oxide: heart of the microbiota–CVD nexus? by Naghipour, Saba, Cox, Amanda J., Peart, Jason N., Du Toit, Eugene F., Headrick, John P.

“…We critically review potential involvement of trimethylamine N-oxide (TMAO) as a link between diet, the gut microbiota and CVD. Generated primarily from…”
Get full text

Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal by Kuck, Lennart, McNamee, Antony P, Bordukova, Maria, Sadafi, Ario, Marr, Carsten, Peart, Jason N, Simmonds, Michael J

“…Hematopoietic stem cells surrender organelles during differentiation, leaving mature red blood cells (RBC) devoid of transcriptional machinery and…”
Get full text

Loss of caveolin-1 accelerates neurodegeneration and aging by Head, Brian P, Peart, Jason N, Panneerselvam, Mathivadhani, Yokoyama, Takaakira, Pearn, Matthew L, Niesman, Ingrid R, Bonds, Jacqueline A, Schilling, Jan M, Miyanohara, Atsushi, Headrick, John, Ali, Sameh S, Roth, David M, Patel, Piyush M, Patel, Hemal H

“…The aged brain exhibits a loss in gray matter and a decrease in spines and synaptic densities that may represent a sequela for neurodegenerative diseases such…”
Get full text

Opioid receptors and cardioprotection – ‘opioidergic conditioning’ of the heart by Headrick, John P, See Hoe, Louise E, Du Toit, Eugene F, Peart, Jason N

“…Ischaemic heart disease (IHD) remains a major cause of morbidity/mortality globally, firmly established in Westernized or ‘developed’ countries and rising in…”
Get full text

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury by Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xia, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E., Thomas, Walter G., King, Glenn F., Macdonald, Peter S., Palpant, Nathan J.

“…Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac…”
Get full text

KATP channels and myocardial preconditioning: an update by Gross, Garrett J, Peart, Jason N

“…Ischemic or myocardial preconditioning (IPC) is a phenomenon whereby brief periods of ischemia have been shown to protect the myocardium against a more…”
Get more information

Bitter taste receptor agonists elicit G‐protein‐dependent negative inotropy in the murine heart by Foster, Simon R., Blank, Kristina, Hoe, Louise E. See, Behrens, Maik, Meyerhof, Wolfgang, Peart, Jason N., Thomas, Walter G.

“…G‐protein‐coupled receptors (GPCRs) are key mediators in cardiovascular physiology, yet frontline therapies for heart disease target only a small fraction of…”
Get full text

Dietary α-Linolenic Acid Counters Cardioprotective Dysfunction in Diabetic Mice: Unconventional PUFA Protection by Russell, Jake S, Griffith, Tia A, Naghipour, Saba, Vider, Jelena, Du Toit, Eugene F, Patel, Hemal H, Peart, Jason N, Headrick, John P

“…Whether dietary omega-3 (n-3) polyunsaturated fatty acid (PUFA) confers cardiac benefit in cardiometabolic disorders is unclear. We test whether dietary…”
Get full text

Non-analgesic effects of opioids: cardiovascular effects of opioids and their receptor systems by Headrick, John P, Pepe, Salvatore, Peart, Jason N

“…Opioid peptides and their G protein-coupled receptors (GPCRs) are important regulators within the cardiovascular system, implicated in modulation of…”
Get more information

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation by Headrick, John P., Peart, Jason N., Reichelt, Melissa E., Haseler, Luke J.

“…The purine nucleoside adenosine is an important regulator within the cardiovascular system, and throughout the body. Released in response to perturbations in…”
Get full text

Central and cardiac stress resilience consistently linked to integrated immuno‐neuroendocrine responses across stress models in male mice by Helman, Tessa J., Headrick, John P., Peart, Jason N., Stapelberg, Nicolas J. C.

“…Stress resilience, and behavioural and cardiovascular impacts of chronic stress, are theorised to involve integrated…”
Get full text

Adenosinergic cardioprotection: multiple receptors, multiple pathways by Peart, Jason N, Headrick, John P

“…Adenosine, formed primarily via hydrolysis of 5'-AMP, has been historically dubbed a "retaliatory" metabolite due to enhanced local release and beneficial…”
Get full text

Sex‐specific behavioral, neurobiological, and cardiovascular responses to chronic social stress in mice by Helman, Tessa J., Headrick, John P., Vider, Jelena, Peart, Jason N., Stapelberg, Nicolas J. C.

“…Psychosocial stress promotes and links mood and cardiovascular disorders in a sex‐specific manner. However, findings in animal models are equivocal, in some…”
Get full text

Clinical cardioprotection and the value of conditioning responses by Peart, Jason N, Headrick, John P

“…Adjunctive cardioprotective strategies for ameliorating the reversible and irreversible injuries with ischemia-reperfusion (I/R) are highly desirable. However,…”
Get more information

Unique transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic myocardium by Ashton, Kevin J, Tupicoff, Amanda, Williams-Pritchard, Grant, Kiessling, Can J, See Hoe, Louise E, Headrick, John P, Peart, Jason N

“…Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3-5 days of opioid receptor (OR) agonism induces persistent protection against…”
Get full text

Complex Effects of Putative DRP-1 Inhibitors on Stress Responses in Mouse Heart and Rat Cardiomyoblasts by Wendt, Lauren, Vider, Jelena, Hoe, Louise E See, Du Toit, Eugene, Peart, Jason N, Headrick, John P

“…Dynamin-related protein-1 (DRP-1)-dependent mitochondrial fission may influence cardiac tolerance to ischemic or oxidative stress, presenting a potential…”
Get full text

The heartbreak of depression: ‘Psycho-cardiac’ coupling in myocardial infarction by Headrick, John P, Peart, Jason N, Budiono, Boris P, Shum, David H.K, Neumann, David L, Stapelberg, Nicolas J.C

“…Abstract Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant…”
Get full text