Search Results - "Pearson, Selina"

Mouse screen reveals multiple new genes underlying mouse and human hearing loss by Ingham, Neil J, Pearson, Selina A, Vancollie, Valerie E, Rook, Victoria, Lewis, Morag A, Chen, Jing, Buniello, Annalisa, Martelletti, Elisa, Preite, Lorenzo, Lam, Chi Chung, Weiss, Felix D, Powis, Zӧe, Suwannarat, Pim, Lelliott, Christopher J, Dawson, Sally J, White, Jacqueline K, Steel, Karen P

“…Adult-onset hearing loss is very common, but we know little about the underlying molecular pathogenesis impeding the development of therapies. We took a…”
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Ecto‐5′‐nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia by Holmes, Andrew P., Ray, Clare J., Pearson, Selina A., Coney, Andrew M., Kumar, Prem

“…Key points Carotid body dysfunction is recognized as a cause of hypertension in a number of cardiorespiratory diseases states and has therefore been identified…”
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AMP-activated Protein Kinase Mediates Carotid Body Excitation by Hypoxia by Wyatt, Christopher N., Mustard, Kirsty J., Pearson, Selina A., Dallas, Mark L, Atkinson, Lucy, Kumar, Prem, Peers, Chris, Hardie, D. Grahame, Evans, A. Mark

“…Early detection of an O2 deficit in the bloodstream is essential to initiate corrective changes in the breathing pattern of mammals. Carotid bodies serve an…”
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Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme by Lewis, Morag A, Ingham, Neil J, Chen, Jing, Pearson, Selina, Di Domenico, Francesca, Rekhi, Sohinder, Allen, Rochelle, Drake, Matthew, Willaert, Annelore, Rook, Victoria, Pass, Johanna, Keane, Thomas, Adams, David J, Tucker, Abigail S, White, Jacqueline K, Steel, Karen P

“…Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated…”
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WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy by Kannan, Meghna, Bayam, Efil, Wagner, Christel, Rinaldi, Bruno, Kretz, Perrine F., Tilly, Peggy, Roos, Marna, McGillewie, Lara, Bär, Séverine, Minocha, Shilpi, Chevalier, Claire, Po, Chrystelle, Project, Sanger Mouse Genetics, Chelly, Jamel, Mandel, Jean-Louis, Borgatti, Renato, Piton, Amélie, Kinnear, Craig, Loos, Ben, Adams, David J., Hérault, Yann, Collins, Stephan C., Friant, Sylvie, Godin, Juliette D., Yalcin, Binnaz

“…The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes…”
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Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene by Maguire, Simon, Estabel, Jeanne, Ingham, Neil, Pearson, Selina, Ryder, Edward, Carragher, Damian M, Walker, Nicolas, Bussell, James, Chan, Wai-In, Keane, Thomas M, Adams, David J, Scudamore, Cheryl L, Lelliott, Christopher J, Ramírez-Solis, Ramiro, Karp, Natasha A, Steel, Karen P, White, Jacqueline K, Gerdin, Anna-Karin

“…Homozygosity for Slc25a21(tm1a(KOMP)Wtsi) results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment…”
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Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media by Kuhn, Stephanie, Ingham, Neil, Pearson, Selina, Gribble, Susan M, Clayton, Stephen, Steel, Karen P, Marcotti, Walter

“…Down syndrome is one of the most common congenital disorders leading to a wide range of health problems in humans, including frequent otitis media. The Tc1…”
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Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects by Steffes, Georg, Lorente-Cánovas, Beatriz, Pearson, Selina, Brooker, Rachael H, Spiden, Sarah, Kiernan, Amy E, Guénet, Jean-Louis, Steel, Karen P

“…Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new spontaneous alleles of the Lmx1a gene in mice. Homozygous mutants show head tossing and…”
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Peptidergic Activation of Locomotor Pattern Generators in the Neonatal Spinal Cord by Pearson, Selina A, Mouihate, Abdeslam, Pittman, Quentin J, Whelan, Patrick J

“…The development of motor networks in the spinal cord is partly activity-dependent. We have observed receptor-mediated excitatory effects of two peptides,…”
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Key roles for AMP-activated protein kinase in the function of the carotid body? by Wyatt, Christopher N, Pearson, Selina A, Kumar, Prem, Peers, Chris, Hardie, D Grahame, Evans, A Mark

“…The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites…”
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Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes by White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Barnes, Caroline, Cambridge, Emma, Carragher, Damian, Chana, Prabhjoat, Clarke, Kay, Igosheva, Natalia, Ismail, Ozama, Jackson, Hannah, Kane, Leanne, Lacey, Rosalind, Lucas, Mark, McGill, Katherine, McIntyre, Rebecca E., Messager, Sophie, Mottram, Lynda, Mulderrig, Lee, Pearson, Selina, Roberson, Laura-Anne, Salsbury, Grace, Sanger, Daniel, Shannon, Carl, Thompson, Paul C., Tuck, Elizabeth, Bushell, Wendy, Cook, Ross, Dalvi, Priya, Gleeson, Diane, Habib, Bishoy, Hardy, Matt, Miklejewska, Evelina, Price, Stacey, Sethi, Debarati, von Schiller, Dominique, Vyas, Sapna, West, Anthony P., Evans, Arthur, Holroyd, Simon, Iyer, Vivek, Lewis, Morag, Oakley, Darren, Richardson, David, Smedley, Damian, Agu, Chukwuma, Bryant, Jackie, Delaney, Liz, Gueorguieva, Nadia I., Tharagonnet, Helen, Townsend, Anne J., Biggs, Daniel, Collinson, Adam, Dumeau, Charles-Etienne, Grau, Evelyn, Harrison, Sarah, Ingle, Catherine E., Kundi, Helen, Madich, Alla, Mayhew, Danielle, Metcalf, Tom, Pass, Johanna, Reynolds, Helen, Sinclair, Caroline, Wardle-Jones, Hannah, Woods, Michael, Alexander, Liam, Brown, Terry, Flack, Francesca, Griggs, Nicola, McDermott, Jordan, Rogerson, Claire, White, Gemma, Zielezinski, Pawel, DiTommaso, Tia, Edwards, Andrew, Mahajan, Mary Ann, Yalcin, Binnaz, Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Bradley, Allan

“…Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse…”
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Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome by Balmus, Gabriel, Larrieu, Delphine, Barros, Ana C., Collins, Casey, Abrudan, Monica, Demir, Mukerrem, Geisler, Nicola J., Lelliott, Christopher J., White, Jacqueline K., Karp, Natasha A., Atkinson, James, Kirton, Andrea, Jacobsen, Matt, Clift, Dean, Rodriguez, Raphael, Adams, David J., Jackson, Stephen P.

“…Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease…”
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S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse by Ingham, Neil J., Carlisle, Francesca, Pearson, Selina, Lewis, Morag A., Buniello, Annalisa, Chen, Jing, Isaacson, Rivka L., Pass, Johanna, White, Jacqueline K., Dawson, Sally J., Steel, Karen P.

“…Progressive hearing loss is very common in the population but we still know little about the underlying pathology. A new spontaneous mouse mutation (stonedeaf,…”
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Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice by Hilton, Jennifer M, Lewis, Morag A, Grati, M'hamed, Ingham, Neil, Pearson, Selina, Laskowski, Roman A, Adams, David J, Steel, Karen P

“…Inflammation of the middle ear (otitis media) is very common and can lead to serious complications if not resolved. Genetic studies suggest an inherited…”
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A gene expression resource generated by genome-wide lacZ profiling in the mouse by Tuck, Elizabeth, Estabel, Jeanne, Oellrich, Anika, Maguire, Anna Karin, Adissu, Hibret A, Souter, Luke, Siragher, Emma, Lillistone, Charlotte, Green, Angela L, Wardle-Jones, Hannah, Carragher, Damian M, Karp, Natasha A, Smedley, Damian, Adams, Niels C, Bussell, James N, Adams, David J, Ramírez-Solis, Ramiro, Steel, Karen P, Galli, Antonella, White, Jacqueline K

“…Knowledge of the expression profile of a gene is a critical piece of information required to build an understanding of the normal and essential functions of…”
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A role for TRP channels in carotid body chemotransduction? by Kumar, Prem, Pearson, Selina, Gu, Yuchun

“…The hypoxia‐induced inhibition of type I cell, K channels leads to membrane potential depolarization and subsequent calcium entry and neurosecretion. Whilst…”
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Targeting of Slc25a21 Is Associated with Orofacial Defects and Otitis Media Due to Disrupted Expression of a Neighbouring Gene: e91807 by Maguire, Simon, Estabel, Jeanne, Ingham, Neil, Pearson, Selina, Ryder, Edward, Carragher, Damian M, Walker, Nicolas, Bussell, James, Chan, Wai-In

“…Homozygosity for Slc25a21tm1a(KOMP)Wtsi results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment and…”
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Exome sequencing identifies a missense mutation in Isl1associated with low penetrance otitis media in dearisch mice by Hilton, Jennifer M, Lewis, Morag A, Grati, M'hamed, Ingham, Neil, Pearson, Selina, Laskowski, Roman A, Adams, David J, Steel, Karen P

“…Abstract Background Inflammation of the middle ear (otitis media) is very common and can lead to serious complications if not resolved. Genetic studies suggest…”
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