Search Results - "Pearson, Jaclyn S."

Host Cell Death Responses to Non-typhoidal Salmonella Infection by Wemyss, Madeleine A, Pearson, Jaclyn S

“…subsp. serovar Typhimurium ( . Typhimurium) is a Gram-negative bacterium with a broad host range that causes non-typhoidal salmonellosis in humans. …”
Get full text

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
Get full text

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation by Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.

“…Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases…”
Get full text

The Genetics of Enteropathogenic Escherichia coli Virulence by Pearson, Jaclyn S, Giogha, Cristina, Wong Fok Lung, Tania, Hartland, Elizabeth L

“…In many parts of the world, enteropathogenic Escherichia coli (EPEC) are a leading cause of death in children with diarrhea. Much of what we know about the…”
Get full text

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements by Wong, Alexander R. C., Pearson, Jaclyn S., Bright, Michael D., Munera, Diana, Robinson, Keith S., Lee, Sau Fung, Frankel, Gad, Hartland, Elizabeth L.

“…Summary The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) share a unique mechanism of colonization that results from…”
Get full text

Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia by Ingle, Danielle J., Ambrose, Rebecca L., Baines, Sarah L., Duchene, Sebastian, Gonçalves da Silva, Anders, Lee, Darren Y. J., Jones, Miriam, Valcanis, Mary, Taiaroa, George, Ballard, Susan A., Kirk, Martyn D., Howden, Benjamin P., Pearson, Jaclyn S., Williamson, Deborah A.

“…Salmonella enterica serovar 4,[5],12:i:- ( Salmonella 4,[5],12:i:-) is a monophasic variant of Salmonella Typhimurium that has emerged as a global cause of…”
Get full text

Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides by Valentin, Roxane, Wong, Christophe, Alharbi, Arwaf S, Pradeloux, Solène, Morros, Makala P, Lennox, Kim A, Ellyard, Julia I, Garcin, Aurélie J, Ullah, Tomalika R, Kusuma, Gina D, Pépin, Geneviève, Li, Hong-Mei, Pearson, Jaclyn S, Ferrand, Jonathan, Lim, Rebecca, Veedu, Rakesh N, Morand, Eric F, Vinuesa, Carola G, Behlke, Mark A, Gantier, Michael P

“…Abstract Oligonucleotide-based therapeutics have the capacity to engage with nucleic acid immune sensors to activate or block their response, but a detailed…”
Get full text

Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ by Zhang, Ying, Mühlen, Sabrina, Oates, Clare V., Pearson, Jaclyn S., Hartland, Elizabeth L.

“…The type III secretion system effector protein NleE from enteropathogenic Escherichia coli plays a key role in the inhibition of NF-κB activation during…”
Get full text

NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector by Giogha, Cristina, Scott, Nichollas E, Wong Fok Lung, Tania, Pollock, Georgina L, Harper, Marina, Goddard-Borger, Ethan D, Pearson, Jaclyn S, Hartland, Elizabeth L

“…During infection, enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E . coli (EHEC) directly manipulate various aspects of host cell function…”
Get full text

Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli by Pollock, Georgina L, Oates, Clare V L, Giogha, Cristina, Wong Fok Lung, Tania, Ong, Sze Ying, Pearson, Jaclyn S, Hartland, Elizabeth L

“…During infection, enteropathogenic (EPEC) translocates effector proteins directly into the cytosol of infected enterocytes using a type III secretion system…”
Get full text

Mutagenesis and Functional Analysis of the Bacterial Arginine Glycosyltransferase Effector NleB1 from Enteropathogenic Escherichia coli by Wong Fok Lung, Tania, Giogha, Cristina, Creuzburg, Kristina, Ong, Sze Ying, Pollock, Georgina L, Zhang, Ying, Fung, Ka Yee, Pearson, Jaclyn S, Hartland, Elizabeth L

“…Enteropathogenic Escherichia coli (EPEC) interferes with host cell signaling by injecting virulence effector proteins into enterocytes via a type III secretion…”
Get full text

Editorial: Bacterial Effectors as Drivers of Human Disease: Models, Methods, Mechanisms by Schroeder, Gunnar N., Pearson, Jaclyn S., Thurston, Teresa L. M.

Get full text

Post-modern pathogens: surprising activities of translocated effectors from E. coli and Legionella by Pearson, Jaclyn S, Zhang, Ying, Newton, Hayley J, Hartland, Elizabeth L

“…Highlights • Many Gram-negative bacterial pathogens translocate diverse sets of effector proteins into cells during infection using type III, type IV and type…”
Get full text

The Salmonella Effector SseK3 Targets Small Rab GTPases by Gan, Jiyao, Scott, Nichollas E, Newson, Joshua P M, Wibawa, Rachelia R, Wong Fok Lung, Tania, Pollock, Georgina L, Ng, Garrett Z, van Driel, Ian, Pearson, Jaclyn S, Hartland, Elizabeth L, Giogha, Cristina

“…During infection, species inject multiple type III secretion system (T3SS) effector proteins into host cells that mediate invasion and subsequent intracellular…”
Get full text

In vivo studies on Citrobacter rodentium and host cell death pathways by Eng, Vik Ven, Pearson, Jaclyn S

“…•Citrobacter rodentium is a key physiological model for studying A/E pathogenesis.•C. rodentium encodes effectors that subvert host cell death signaling.•C…”
Get full text

Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants by Ingle, Danielle J., Tauschek, Marija, Edwards, David J., Hocking, Dianna M., Pickard, Derek J., Azzopardi, Kristy I., Amarasena, Thakshila, Bennett-Wood, Vicki, Pearson, Jaclyn S., Tamboura, Boubou, Antonio, Martin, Ochieng, John B., Oundo, Joseph, Mandomando, Inácio, Qureshi, Shahida, Ramamurthy, Thandavarayan, Hossain, Anowar, Kotloff, Karen L., Nataro, James P., Dougan, Gordon, Levine, Myron M., Robins-Browne, Roy M., Holt, Kathryn E.

“…Atypical enteropathogenic Escherichia coli (aEPEC) is an umbrella term given to E. coli that possess a type III secretion system encoded in the locus of…”
Get full text

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death by Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.

“…Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated…”
Get full text

The diverse roles of RIP kinases in host-pathogen interactions by Eng, Vik Ven, Wemyss, Madeleine A., Pearson, Jaclyn S.

“…Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and…”
Get full text

Shigella shuts down the pyrop-technic show by Giogha, Cristina, Pearson, Jaclyn S.

“…Shigella is a highly infectious human pathogen, yet mice are naturally resistant to infection. In this issue of Cell Host & Microbe, Luchetti et al. (2021)…”
Get full text

Characterization of the ospZ Promoter in Shigella flexneri and Its Regulation by VirB and H-NS by Basta, David W, Pew, Krystle L, Immak, Joy A, Park, Hiromichi S, Picker, Michael A, Wigley, Amanda F, Hensley, Christopher T, Pearson, Jaclyn S, Hartland, Elizabeth L, Wing, Helen J

“…OspZ is an effector protein of the type III secretion system in Shigella spp. that downregulates the human inflammatory response during bacterial infection…”
Get full text