Search Results - "Pearson, Gray W."

Control of Invasion by Epithelial-to-Mesenchymal Transition Programs during Metastasis by Pearson, Gray W

“…Epithelial-to-mesenchymal transition (EMT) programs contribute to the acquisition of invasive properties that are essential for metastasis. It is well…”
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An epigenetically distinct breast cancer cell subpopulation promotes collective invasion by Westcott, Jill M, Prechtl, Amanda M, Maine, Erin A, Dang, Tuyen T, Esparza, Matthew A, Sun, Han, Zhou, Yunyun, Xie, Yang, Pearson, Gray W

“…Tumor cells can engage in a process called collective invasion, in which cohesive groups of cells invade through interstitial tissue. Here, we identified an…”
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miR614 Expression Enhances Breast Cancer Cell Motility by Dang, Tuyen T, McIntosh, Alec T, Morales, Julio C, Pearson, Gray W

“…Using a data driven analysis of a high-content screen, we have uncovered new regulators of epithelial-to-mesenchymal transition (EMT) induced cell migration…”
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Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231 by Xiao, Jerry, McGill, Joseph R., Nasir, Apsra, Lekan, Alexander, Johnson, Bailey, Wilkins, Devan J., Pearson, Gray W., Tanner, Kandice, Goodarzi, Hani, Glasgow, Eric, Schlegel, Richard, Agarwal, Seema

“…Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer metastasis…”
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PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture by Pearson, Gray W, Hunter, Tony

“…Epithelial tumors, including breast cancer, are being identified and treated at earlier stages of tumor development because of technological advances in…”
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The MAP kinase ERK5 binds to and phosphorylates p90 RSK by Ranganathan, Aarati, Pearson, Gray W., Chrestensen, Carol A., Sturgill, Thomas W., Cobb, Melanie H.

“…We showed previously that p90 RSK was activated in cells expressing an activated mutant of MEK5, the activator of the MAP kinase ERK5. Based on the following…”
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Cyclic AMP Selectively Uncouples Mitogen-Activated Protein Kinase Cascades from Activating Signals by Pearson, Gray W., Earnest, Svetlana, Cobb, Melanie H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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WNK1 Enhances Migration and Invasion in Breast Cancer Models by Jaykumar, Ankita B, Jung, Ji-Ung, Parida, Pravat Kumar, Dang, Tuyen T, Wichaidit, Chonlarat, Kannangara, Ashari Rashmi, Earnest, Svetlana, Goldsmith, Elizabeth J, Pearson, Gray W, Malladi, Srinivas, Cobb, Melanie H

“…Metastasis is the major cause of mortality in patients with breast cancer. Many signaling pathways have been linked to cancer invasiveness, but blockade of few…”
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ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program by Dang, Tuyen T, Esparza, Matthew A, Maine, Erin A, Westcott, Jill M, Pearson, Gray W

“…Cell identity signals influence the invasive capability of tumor cells, as demonstrated by the selection for programs of epithelial-to-mesenchymal transition…”
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An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer by Sharif, Ghada M, Campbell, Moray J, Nasir, Apsra, Sengupta, Surojeet, Graham, Garrett T, Kushner, Max H, Kietzman, William B, Schmidt, Marcel O, Pearson, Gray W, Loudig, Olivier, Fineberg, Susan, Wellstein, Anton, Riegel, Anna T

“…AIB1Δ4 is an N-terminally truncated isoform of the oncogene amplified in breast cancer 1 (AIB1) with increased expression in high-grade human ductal carcinoma…”
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ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion by Dang, Tuyen T, Westcott, Jill M, Maine, Erin A, Kanchwala, Mohammed, Xing, Chao, Pearson, Gray W

“…Tumor invasion can be induced by changes in gene expression that alter cell phenotype. The transcription factor ΔNp63α promotes basal-like breast cancer (BLBC)…”
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Breast Cancer Subtype-Specific Interactions with the Microenvironment Dictate Mechanisms of Invasion by DANG, Tuyen T, PRECHTL, Amanda M, PEARSON, Gray W

“…Most ductal breast carcinoma cells are weakly invasive in vitro and in vivo, suggesting that components of their microenvironment may facilitate a transition…”
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ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion by Westcott, Jill M, Camacho, Sharon, Nasir, Apsra, Huysman, Molly E, Rahhal, Raneen, Dang, Tuyen T, Riegel, Anna T, Brekken, Rolf A, Pearson, Gray W

“…Defining how interactions between tumor subpopulations contribute to invasion is essential for understanding how tumors metastasize. Here, we find that the…”
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Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells by Pearson, Gray W, Hunter, Tony

“…To determine how extracellular signal-regulated kinases (ERK) 1/2 promote mammary tumorigenesis, we examined the real-time behavior of cells in an organotypic…”
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The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion by Maine, Erin A, Westcott, Jill M, Prechtl, Amanda M, Dang, Tuyen T, Whitehurst, Angelique W, Pearson, Gray W

“…Genes that are normally biased towards expression in the testis are often induced in tumor cells. These gametogenic genes, known as cancer-testis antigens…”
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Cell Condition-dependent Regulation of ERK5 by cAMP by Pearson, Gray W, Cobb, Melanie H

“…ERK5 activity is increased by agents known to activate receptor tyrosine kinases, G-protein coupled receptors, and stress response pathways. We now find a role…”
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Abstract A38: Breast cancer intrinsic subtype specific interactions with the microenvironment dictate the mechanism of tumor invasion by Dang, Tuyen T., Pearson, Gray W.

“…Breast cancer patient mortality is a consequence of the metastatic dissemination of neoplastic cells into foreign tissues, not the primary tumor growth…”
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