Search Results - "Pearson, Daniel S."

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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MicroRNA‐27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia by Vickers, Kasey C., Shoucri, Bassem M., Levin, Michael G., Wu, Han, Pearson, Daniel S., Osei‐Hwedieh, David, Collins, Francis S., Remaley, Alan T., Sethupathy, Praveen

“…Cellular and plasma lipid levels are tightly controlled by complex gene regulatory mechanisms. Elevated plasma lipid content, or hyperlipidemia, is a…”
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LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency by Tsanov, Kaloyan M., Pearson, Daniel S., Wu, Zhaoting, Han, Areum, Triboulet, Robinson, Seligson, Marc T., Powers, John T., Osborne, Jihan K., Kane, Susan, Gygi, Steven P., Gregory, Richard I., Daley, George Q.

“…Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability…”
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Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis by Rowe, R Grant, Wang, Leo D, Coma, Silvia, Han, Areum, Mathieu, Ronald, Pearson, Daniel S, Ross, Samantha, Sousa, Patricia, Nguyen, Phi T, Rodriguez, Antony, Wagers, Amy J, Daley, George Q

“…For appropriate development, tissue and organ system morphogenesis and maturation must occur in synchrony with the overall developmental requirements of the…”
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Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver by Kurtz, C. Lisa, Fannin, Emily E., Toth, Cynthia L., Pearson, Daniel S., Vickers, Kasey C., Sethupathy, Praveen

“…MicroRNAs (miRNAs) are important regulators and potential therapeutic targets of metabolic disease. In this study we show by in vivo administration of locked…”
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Safety and Efficacy of a Preemptive Mycophenolate Mofetil Dose Reduction Strategy in Kidney Transplant Recipients by Yatim, Karim, Al Jurdi, Ayman, El Mouhayyar, Christopher, Morena, Leela, Hullekes, Frank E, Verhoeff, Ruchama, Ribas, Guilherme T, Pearson, Daniel S, V Riella, Leonardo

“…There are no high-quality data to guide long-term mycophenolate mofetil (MMF) dosing in kidney transplant recipients (KTRs) to balance the long-term risks of…”
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Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28 by Wang, Longfei, Rowe, R. Grant, Jaimes, Adriana, Yu, Chunxiao, Nam, Yunsun, Pearson, Daniel S., Zhang, Jin, Xie, Xiangyu, Marion, William, Heffron, Gregory J., Daley, George Q., Sliz, Piotr

“…LIN28 is an RNA-binding protein that regulates the maturation of the let-7 family of microRNAs by bipartite interactions with let-7 precursors through its two…”
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Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies by Pearson, Daniel S, McEvoy, Dustin S, Murali, Mandakolathur R, Dighe, Anand S

“…There is considerable variation in ordering practices for the initial laboratory evaluation of monoclonal gammopathies (MGs) despite clear society guidelines…”
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Case 33-2023: An 86-Year-Old Man with Shortness of Breath by Luis, Sushil Allen, Chung, Ryan, Stefanescu Schmidt, Ada C., Clark, Jeffrey W., Pearson, Daniel S.

“…An 86-year-old man was admitted to the hospital because of shortness of breath and hypoxemia. Echocardiography revealed severe tricuspid regurgitation and a…”
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LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy by Missios, Pavlos, da Rocha, Edroaldo Lummertz, Pearson, Daniel S, Philipp, Julia, Aleman, Maria M, Pirouz, Mehdi, Farache, Dorian, Franses, Joseph W, Kubaczka, Caroline, Tsanov, Kaloyan M, Jha, Deepak K, Pepe-Mooney, Brian, Powers, John T, Gregory, Richard I, Lee, Amy Sy, Dominguez, Daniel, Ting, David T, Daley, George Q

“…High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed…”
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A nanobody targeting the LIN28: let-7 interaction fragment of TUT4 blocks uridylation of let-7 by Yu, Chunxiao, Wang, Longfei, Rowe, R. Grant, Han, Areum, Ji, Wanying, McMahon, Conor, Baier, Alexander S., Huang, Yu-Chung, Marion, William, Pearson, Daniel S., Kruse, Andrew C., Daley, George Q., Wu, Hao, Sliz, Piotr

“…The LIN28:pre-let-7:TUTase ternary complex regulates pluripotency and oncogenesis by controlling processing of the let-7 family of microRNAs. The complex…”
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Global Epigenomic Analysis of Primary Human Pancreatic Islets Provides Insights into Type 2 Diabetes Susceptibility Loci by Stitzel, Michael L., Sethupathy, Praveen, Pearson, Daniel S., Chines, Peter S., Song, Lingyun, Erdos, Michael R., Welch, Ryan, Parker, Stephen C.J., Boyle, Alan P., Scott, Laura J., Margulies, Elliott H., Boehnke, Michael, Furey, Terrence S., Crawford, Gregory E., Collins, Francis S.

“…Identifying cis-regulatory elements is important to understanding how human pancreatic islets modulate gene expression in physiologic or pathophysiologic…”
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Lin28 paralogs regulate lung branching morphogenesis by Osborne, Jihan K., Kinney, Melissa A., Han, Areum, Akinnola, Kemi E., Yermalovich, Alena V., Vo, Linda T., Pearson, Daniel S., Sousa, Patricia M., Ratanasirintrawoot, Sutheera, Tsanov, Kaloyan M., Barragan, Jessica, North, Trista E., Metzger, Ross J., Daley, George Q.

“…The molecular mechanisms that govern the choreographed timing of organ development remain poorly understood. Our investigation of the role of the Lin28a and…”
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Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies by Pearson, Daniel S., McEvoy, Dustin, Murali, Mandakolathur, Dighe, Anand

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An Essential Role for the RNA Editor-Exonuclease Axis in Terminal Erythroid Differentiation by Han, Areum, Yermalovich, Alena V., Lundin, Vanessa, Pearson, Daniel S., Hachimi, Mariam, Sousa, Patricia, Hilton, Brianna, Morse, Michael, Atwater, John, Zhang, Yosra, Hunter, Pheobe, Morris, Vivian, Osborne, Jihan K., Frame, Jenna M., Jing, Ran, Huang, Yu Chung, Kubaczka, Caroline, North, Trista E., Schlaeger, Thorsten, Daley, George Q.

“…Erythropoiesis is an intricate process by which lineage-committed erythroid progenitors become mature red blood cells. Reticulocytes are terminal-staged,…”
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Case report: Successful simultaneous heart-kidney transplantation across a positive complement-dependent cytotoxic crossmatch by Yamamoto, Takayuki, Pearson, Daniel S., Ababneh, Emad I., Harris, Cynthia, Nissaisorakarn, Pitchaphon, Mahowald, Grace K., Heher, Yael K., Elias, Nahel, Markmann, James F., Lewis, Gregory D., Riella, Leonardo V.

“…Preformed donor-specific antibodies are associated with a higher risk of rejection and worse graft survival in organ transplantation. However, in heart…”
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Novel Roles for the Terminal RNA Uridylyltransferases ZCCHC6 and ZCCHC11 in Development and Disease by Pearson, Daniel S

“…Terminal RNA uridylyltransferases (TUTases) are a class of non-canonical polyadenylate polymerases that are thought to function primarily by adding…”
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The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy by Wang, L D, Rao, T N, Rowe, R G, Nguyen, P T, Sullivan, J L, Pearson, D S, Doulatov, S, Wu, L, Lindsley, R C, Zhu, H, DeAngelo, D J, Daley, G Q, Wagers, A J

“…Mast cells (MCs) are critical components of the innate immune system and important for host defense, allergy, autoimmunity, tissue regeneration and tumor…”
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Abstract 24: MicroRNA-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia by Vickers, Kasey C, Shoucri, Bassem M, Levin, Michael G, Wu, Han, Osei-Hwedieh, David, Pearson, Daniel S, Collins, Francis S, Sethupathy, Praveen, Remaley, Alan T

“…Abstract only Cellular and plasma lipid levels are tightly controlled by complex gene regulatory mechanisms. MicroRNAs (miRNAs) are post-transcriptional…”
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Global Epigenomic Analysis of Primary Human Pancreatic Islets Provides Insights into Type 2 Diabetes Susceptibility Loci by Stitzel, Michael L., Sethupathy, Praveen, Pearson, Daniel S., Chines, Peter S., Song, Lingyun, Erdos, Michael R., Welch, Ryan, Parker, Stephen C.J., Boyle, Alan P., Scott, Laura J., Sequencing Program, NISC Comparative, Margulies, Elliott H., Boehnke, Michael, Furey, Terrence S., Crawford, Gregory E., Collins, Francis S.

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