Search Results - "Pearson, Craig S."
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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS
Published in Nature communications (05-11-2020)“…Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to…”
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Identification of a critical sulfation in chondroitin that inhibits axonal regeneration
Published in eLife (15-05-2018)“…The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury,…”
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Old but not obsolete: an enhanced high-speed immunoblot
Published in Journal of biochemistry (Tokyo) (01-07-2020)“…Abstract The immunoblotting technique (also known as western blotting) is an essential tool used in biomedical research to determine the relative size and…”
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PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS
Published in EMBO molecular medicine (07-08-2020)“…Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after…”
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5
Flexible Roles for Proteoglycan Sulfation and Receptor Signaling
Published in Trends in neurosciences (Regular ed.) (01-01-2018)“…Proteoglycans (PGs) in the extracellular matrix (ECM) play vital roles in axon growth and navigation, plasticity, and regeneration of injured neurons…”
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Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents
Published in Experimental eye research (01-01-2020)“…The accumulation of chondroitin sulfate proteoglycans (CSPGs) in the glial scar following acute damage to the central nervous system (CNS) limits the…”
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7
Old but not obsolete: an enhanced high-speed immunoblot
Published in Journal of biochemistry (Tokyo) (01-09-2020)Get full text
Journal Article -
8
Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm
Published in Investigative ophthalmology & visual science (01-11-2019)“…Regeneration of optic nerve axons after injury can be facilitated by several approaches, but misguidance at the optic chiasm is often observed. We…”
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Reliable and sensitive detection of glycosaminoglycan chains with immunoblots
Published in Glycobiology (Oxford) (09-02-2021)“…Complex glycans play vital roles in many biological processes, ranging from intracellular signaling and organ development to tumor growth. Glycan expression is…”
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Ultra-High-Speed Western Blot using Immunoreaction Enhancing Technology
Published in Journal of visualized experiments (26-09-2020)“…A western blot (also known as an immunoblot) is a canonical method for biomedical research. It is commonly used to determine the relative size and abundance of…”
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Surface microcracks signal osteoblasts to regulate alignment and bone formation
Published in Materials Science & Engineering C (01-11-2014)“…Microcracks are present in bone and can result from fatigue damage due to repeated, cyclically applied stresses. From a mechanical point, microcracks can…”
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PI 3-kinase delta enhances axonal PIP 3 to support axon regeneration in the adult CNS
Published in EMBO molecular medicine (07-08-2020)“…Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after…”
Get full text
Journal Article