Search Results - "Pearse, Bradley R"

Lectin chaperones help direct the maturation of glycoproteins in the endoplasmic reticulum by Pearse, Bradley R., Hebert, Daniel N.

“…Eukaryotic secretory pathway cargo fold to their native structures within the confines of the endoplasmic reticulum (ER). To ensure a high degree of folding…”
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cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein by Pearse, Bradley R, Gabriel, Luke, Wang, Ning, Hebert, Daniel N

“…The endoplasmic reticulum (ER) protein GT1 (UDP-glucose: glycoprotein glucosyltransferase) is the central enzyme that modifies N-linked carbohydrates based…”
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The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza Neuraminidase by Wang, Ning, Glidden, Emily J., Murphy, Stephanie R., Pearse, Bradley R., Hebert, Daniel N.

“…The earliest steps in nascent protein maturation greatly affect its overall efficiency. Constraints placed on maturing proteins at these early stages limit…”
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role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin by Pearse, Bradley R, Tamura, Taku, Sunryd, Johan C, Grabowski, Gregory A, Kaufman, Randal J, Hebert, Daniel N

“…An endoplasmic reticulum (ER) quality control system assists in efficient folding and disposal of misfolded proteins. N-linked glycans are critical in these…”
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Cotranslocational Degradation: Utilitarianism in the ER Stress Response by Pearse, Bradley R., Hebert, Daniel N.

“…Recently, a new layer of the unfolded protein response was discovered that supports the cotranslocational degradation of nascent chains stalled in endoplasmic…”
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Yos9p: A Sweet-Toothed Bouncer of the Secretory Pathway by Cormier, James H., Pearse, Bradley R., Hebert, Daniel N.

“…In this issue of Molecular Cell, Bhamidipati et al. (2005), Kim et al. (2005), and Szathmary et al. (2005) demonstrate that Yos9p selectively binds to aberrant…”
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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant by Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Current regimens for patient preparation, or conditioning, prior to bone marrow transplantation (BMT) limit the use of this curative procedure due to…”
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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML) by Lanieri, Leanne, Lamothe, Tahirih L, Miske, Oliver, McDonough, Sean M, Sarma, Ganapathy N, Bhattarai, Prashant, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Palchaudhuri, Rahul, Knihtila, Ryan, Pearse, Bradley R, Proctor, Jennifer L, Boitano, Anthony E, Cooke, Michael P, Davis, John C.

“…Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative…”
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Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model by Hyzy, Sharon L., Proctor, Jennifer L, Gillard, Geoff O, Hammond, Katelyn J., Sarma, Ganapathy N., Saha, Asim, Clark, Nicholas, Bhat, Anjali, Lamothe, Tahirih L, Palchaudhuri, Rahul, Pearse, Bradley R, McDonagh, Charlotte F, Kiem, Hans-Peter, Wagner, John E, Blazar, Bruce R., Boitano, Anthony E, Cooke, Michael P, Davis, John C.

“…Introduction Allogeneic hematopoietic stem cell transplant (Allo-HSCT) is a potentially curative treatment for malignant and non-malignant blood disorders…”
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Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models by Palchaudhuri, Rahul, Hyzy, Sharon L., Proctor, Jennifer L, Adams, Hillary L, Pearse, Bradley R, Sarma, Ganapathy, Aslanian, Sharon, Gillard, Geoff, Lamothe, Tahirih L, Burenkova, Olga, Brooks, Melissa L., Gabros, Andrew D, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Introduction Targeted antibody drug conjugates (ADCs) to mouse CD45 or mouse CD117 have recently been shown to effectively prepare immunocompetent mice for…”
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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates by Tisdale, John F., Donahue, Robert E., Uchida, Naoya, Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Krouse, Allen, Linde, Nathaniel S., Bonifacino, Aylin C., Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification techniques represents a potential cure for multiple genetic blood…”
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A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP) by Gillard, Geoff O, Proctor, Jennifer L, Brooks, Melissa L., Lamothe, Tahirih L, Hyzy, Sharon L., Mikse, Oliver, McDonough, Sean, Palchaudhuri, Rahul, Bhat, Anjali, Sarma, Ganapathy N., Bhattarai, Prashant, Sawant, Pranoti, Pearse, Bradley R, Mcdonough, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in selected patients with…”
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Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT by Hartigan, Adam J., Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Adams, Hillary L., McShea, Molly A., Hoban, Megan D., Panwar, Rajiv, Hyzy, Sharon L., Goncalves, Kevin A., Palchaudhuri, Rahul, Boitano, Anthony E., Cooke, Michael P.

“…For patients undergoing hematopoietic stem cell transplantation (HSCT), conditioning remains a primary source of transplant related morbidity and mortality and…”
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CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant by Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Panwar, Rajiv, Sarma, Ganapathy, McShea, Molly A, Kien, Lena, Dushime, Junia, Adams, Hillary L, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Background: Genotoxic conditioning prior to allogeneic and autologous bone marrow transplantation (BMT) limits the use of these potentially curative treatments…”
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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models by Proctor, Jennifer L, Hyzy, Sharon L., Adams, Hillary L, Brooks, Melissa L., Gabros, Andrew D, McDonough, Sean M, Kien, Lena, Aslanian, Sharon, Pearse, Bradley R, Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sarma, Ganapathy, McShea, Molly A, Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Background. Allogeneic bone marrow transplant (BMT) is a potentially curative approach in patients with refractory or high risk hematologic malignancies, such…”
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Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning by Palchaudhuri, Rahul, Pearse, Bradley R, Proctor, Jennifer L, Hyzy, Sharon L., Aslanian, Sharon, McDonough, Sean M, Sarma, Ganapathy, Brooks, Melissa L., Bhat, Anjali, Ladwig, Danielle, McShea, Molly A, Kallen, Nathan M, Li, Qing, Panwar, Rajiv, Dushime, Junia, Sawant, Pranoti, Adams, Hillary L, Falahee, Patrick C., Lamothe, Tahirih L, Gabros, Andrew D, Kien, Lena, Gillard, Geoff, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Introduction Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders and has demonstrated impressive…”
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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML) by Lanieri, Leanne, Lamothe, Tahirih L., Mikse, Oliver, McDonough, Sean M., Sarma, Ganapathy N., Bhattarai, Prashant raj, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Knihtila, Ryan, Palchaudhuri, Rahul, Pearse, Bradley R., Boitano, Anthony E., Cooke, Michael P., Davis, John C, Olson, Lisa M, Proctor, Jennifer L.

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Targeted CD45 Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model As a Single Agent by Hyzy, Sharon L., Proctor, Jennifer L., Gillard, Geoffrey O., Hammond, Katelyn J., Sarma, Ganapathy N., Saha, Asim, Clark, Nicholas, Lamothe, Tahirih L., Palchaudhuri, Rahul, Pearse, Bradley R., McDonagh, Charlotte F., Kiem, Hans-Peter, Wagner, John E., Blazar, Bruce R., Boitano, Anthony E., Cooke, Michael P., Davis, John C

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The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza NeuraminidaseS by Wang, Ning, Glidden, Emily J., Murphy, Stephanie R., Pearse, Bradley R., Hebert, Daniel N.

“…The earliest steps in nascent protein maturation greatly affect its overall efficiency. Constraints placed on maturing proteins at these early stages limit…”
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The ER glucosyltransferase reglucosylates non‐native and slow folding domains during glycoprotein maturation by Pearse, Bradley R., Gabriel, Luke, Hebert, Daniel N.

“…The lectin endoplasmic reticulum (ER) quality control system acts to increase the fidelity of nascent glycoprotein folding within the ER. During the…”
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