Search Results - "Pearlman, Eric M"

Interim results of a prospective, randomized, open-label, Phase 3 study of the long-term safety and efficacy of lasmiditan for acute treatment of migraine (the GLADIATOR study) by Brandes, Jan Lewis, Klise, Suzanne, Krege, John H, Case, Michael, Khanna, Rashna, Vasudeva, Raghavendra, Raskin, Joel, Pearlman, Eric M, Kudrow, David

“…To address the need for long-term lasmiditan data, the GLADIATOR study evaluated the safety (primary) and efficacy (secondary) of lasmiditan for the…”
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Comparing the Efficacy and Safety of Galcanezumab Versus Rimegepant for Prevention of Episodic Migraine: Results from a Randomized, Controlled Clinical Trial by Schwedt, Todd J., Myers Oakes, Tina M., Martinez, James M., Vargas, Bert B., Pandey, Hitendra, Pearlman, Eric M., Richardson, Diane R., Varnado, Oralee J., Cobas Meyer, Michael, Goadsby, Peter J.

“…Introduction There have been no prior trials directly comparing the efficacy of different calcitonin gene-related peptide (CGRP) antagonists for migraine…”
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A close association of freedom from pain, migraine-related functional disability, and other outcomes: results of a post hoc analysis of randomized lasmiditan studies SAMURAI and SPARTAN by Lipton, Richard B., Baygani, Simin K., Tepper, Stewart J., Krege, John H., Vasudeva, Raghavendra, Pearlman, Eric M., Hauck, Paula M., Loo, Li Shen

“…Background While pain freedom at 2 h is a key primary outcome for current trials for acute treatment of migraine, the relationship between the degree of head…”
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Topiramate for Migraine Prevention in Children: A Randomized, Double-Blind, Placebo-Controlled Trial by Winner, Paul, Pearlman, Eric M., Linder, Stephen L., Jordan, Donna M., Fisher, Alan C., Hulihan, Joseph

“…Objective.—To assess the efficacy and safety of topiramate for the prevention of pediatric migraine with or without aura in a double‐blind, randomized,…”
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Investigation of the Effect of Lasmiditan on the Pharmacokinetics of P-Glycoprotein and Breast Cancer Resistance Protein Substrates by Luffer-Atlas, Debra, Wilbraham, Darren, Posada, Maria M, Landry, John, Tsai, Max, Pearlman, Eric M

“…Lasmiditan is an in vitro inhibitor of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) efflux transporters. We aimed to confirm predictions…”
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Migraine-Related Stigma and Its Relationship to Disability, Interictal Burden, and Quality of Life: Results of the OVERCOME (US) Study by Shapiro, Robert E, Nicholson, Robert A, Seng, Elizabeth K, Buse, Dawn C, Reed, Michael L, Zagar, Anthony J, Ashina, Sait, Muenzel, E Jolanda, Hutchinson, Susan, Pearlman, Eric M, Lipton, Richard B

“…This population-based analysis characterizes the relative frequency of migraine-related stigma and its cross-sectional relationship to migraine outcomes. We…”
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Diagnosis, consultation, treatment, and impact of migraine in the US: Results of the OVERCOME (US) study by Lipton, Richard B., Nicholson, Robert A., Reed, Michael L., Araujo, Andre B., Jaffe, Dena H., Faries, Douglas E., Buse, Dawn C., Shapiro, Robert E., Ashina, Sait, Cambron‐Mellott, M. Janelle, Rowland, John C., Pearlman, Eric M.

“…Objective The ObserVational survey of the Epidemiology, tReatment and Care of MigrainE (OVERCOME; United States) study is a multicohort, longitudinal web…”
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Efficacy of Galcanezumab for Migraine Prevention in Patients With a Medical History of Anxiety and/or Depression: A Post Hoc Analysis of the Phase 3, Randomized, Double‐Blind, Placebo‐Controlled REGAIN, and Pooled EVOLVE‐1 and EVOLVE‐2 Studies by Smitherman, Todd A., Tietjen, Gretchen E., Schuh, Kory, Skljarevski, Vladimir, Lipsius, Sarah, D’Souza, Deborah N., Pearlman, Eric M.

“…Objective This post hoc analysis evaluated the efficacy of galcanezumab for the prevention of migraine in patients with and without comorbid anxiety and/or…”
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Effects of lasmiditan on simulated driving performance: Results of two randomized, blinded, crossover studies with placebo and active controls by Pearlman, Eric M., Wilbraham, Darren, Dennehy, Ellen B., Berg, Paul H., Tsai, Max, Doty, Erin G., Kay, Gary G.

“…Objective To evaluate the impact of lasmiditan, an oral, centrally‐penetrant, selective serotonin 1F (5‐HT1F) receptor agonist developed for the acute…”
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The clinical spectrum of migraine in children by Dooley, Joseph M, Pearlman, Eric M

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Efficacy and Safety of Galcanezumab for the Preventive Treatment of Migraine: A Narrative Review by Martin, Vincent, Samaan, Karen Hamrick, Aurora, Sheena, Pearlman, Eric M., Zhou, Chunmei, Li, Xiaoping, Pallay, Robert

“…Migraine is a debilitating neurologic disease. People who experience migraine can have substantial disability, impaired functioning and a decreased quality of…”
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Machine learning identifies factors most associated with seeking medical care for migraine: Results of the OVERCOME (US) study by Ashina, Sait, Muenzel, E. Jolanda, Nicholson, Robert A., Zagar, Anthony J., Buse, Dawn C., Reed, Michael L., Shapiro, Robert E., Hutchinson, Susan, Pearlman, Eric M., Lipton, Richard B.

“…Objective Utilize machine learning models to identify factors associated with seeking medical care for migraine. Background Migraine is a leading cause of…”
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Assessment of immunogenicity from galcanezumab phase 3 trials in patients with episodic or chronic migraine by Martinez, James M, Hindiyeh, Nada, Anglin, Greg, Kalidas, Kavita, Hodsdon, Michael E, Kielbasa, William, Moser, Brian A, Pearlman, Eric M, Garces, Sandra

“…This analysis characterizes the immunogenicity profile of galcanezumab, a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide…”
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Onset, Maintenance, and Cessation of Effect of Galcanezumab for Prevention of Migraine: A Narrative Review of Three Randomized Placebo-Controlled Trials by Kuruppu, Dulanji K., North, James M., Kovacik, Amy J., Dong, Yan, Pearlman, Eric M., Hutchinson, Susan L.

“…Introduction Galcanezumab, a humanized monoclonal antibody that binds to calcitonin gene-related peptide, is approved for the preventive treatment of migraine…”
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Galcanezumab Provides Consistent Efficacy Throughout the Dosing Interval Among Patients with Episodic and Chronic Migraine: A Post Hoc Analysis by Pozo-Rosich, Patricia, Samaan, Karen H., Schwedt, Todd J., Nicholson, Robert A., Rettiganti, Mallikarjuna, Pearlman, Eric M.

“…Introduction The consistency of the treatment effect of galcanezumab throughout the dosing interval is examined in patients with episodic and chronic migraine…”
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Factors and Reasons Associated with Hesitating to Seek Care for Migraine: Results of the OVERCOME (US) Study by Shapiro, Robert E., Muenzel, Eva Jolanda, Nicholson, Robert A., Zagar, Anthony J., L. Reed, Michael, Buse, Dawn C., Hutchinson, Susan, Ashina, Sait, Pearlman, Eric M., Lipton, Richard B.

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Managing migraine in children and adolescents by Pearlman, Eric M

“…Although migraine is a well recognized phenomenon in adults, it is often overlooked or minimized in children and adolescents. Headache is a common complaint in…”
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Childhood cerebellar hemangioblastoma does not predict germline or somatic mutations in the von Hippel-Lindau tumor suppressor gene by Fisher, Paul Graham, Tontiplaphol, Art, Pearlman, Eric M., Duffner, Patricia K., Hyder, Douglas J., Stolle, Catherine A., Vortmeyer, Alexander O., Zhuang, Zhengping

“…Tumor suppressor gene “knockout” models would predict that children who present with hemangioblastoma are likely to harbor germline mutation of the von…”
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Burden of Migraine and Migraine-Associated Symptoms in People with Differing Ethnic and Racial Backgrounds: Results of the OVERCOME (US) Study (S41.003) by Buse, Dawn C., Martinez, Betzaida, Muenzel, E. Jolanda, Nicholson, Robert A., Zagar, Anthony J., Cohen, Fred, Hutchinson, Susan, Ashina, Sait, Shapiro, Robert E., Pearlman, Eric M., Lipton, Richard B.

“…Abstract only…”
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Challenge-mig: a phase 4, randomized, double-blind, double-dummy study comparing the efficacy and safety of galcanezumab versus rimegepant for prevention of episodic migraine by Schwedt, Todd J., Myers Oakes, Tina M., Martinez, James M., Vargas, Bert B., Pandey, Hitendra N., Pearlman, Eric M., Richardson, Diane R., Varnado, Oralee J., Meyer, Michael Cobas, Goadsby, Peter J.

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