Search Results - "Pearl, John"

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis by Das, Mrinal K, Savidge, Ben, Pearl, John E, Yates, Thomas, Miles, Gareth, Pareek, Manish, Haldar, Pranabashis, Cooper, Andrea M

“…Chronic inflammation triggers development of metabolic disease, and pulmonary tuberculosis (TB) generates chronic systemic inflammation. Whether TB…”
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The Silent Researcher Critique: A New Method for Obtaining a Critical Response to a Holographic Artwork by John, Pearl

“…The purpose of this article is to provide a plausible answer as to whether the Z-axis of holographic space can be used to depict a chronological narrative with…”
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Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse by Torrado, Egídio, Fountain, Jeffrey J, Robinson, Richard T, Martino, Cynthia A, Pearl, John E, Rangel-Moreno, Javier, Tighe, Michael, Dunn, Robert, Cooper, Andrea M

“…Cell-mediated immune responses are known to be critical for control of mycobacterial infections whereas the role of B cells and humoral immunity is unclear. B…”
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IL-23 and IL-17 in the establishment of protective pulmonary CD4 + T cell responses after vaccination and during Mycobacterium tuberculosis challenge by Cooper, Andrea M, Khader, Shabaana A, Bell, Guy K, Pearl, John E, Fountain, Jeffrey J, Rangel-Moreno, Javier, Cilley, Garth E, Shen, Fang, Eaton, Sheri M, Gaffen, Sarah L, Swain, Susan L, Locksley, Richard M, Haynes, Laura, Randall, Troy D

“…Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by…”
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IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung by Khader, Shabaana A, Guglani, Lokesh, Rangel-Moreno, Javier, Gopal, Radha, Junecko, Beth A Fallert, Fountain, Jeffrey J, Martino, Cynthia, Pearl, John E, Tighe, Michael, Lin, Yin-yao, Slight, Samantha, Kolls, Jay K, Reinhart, Todd A, Randall, Troy D, Cooper, Andrea M

“…IL-23 is required for the IL-17 response to infection with Mycobacterium tuberculosis, but is not required for the early control of bacterial growth. However,…”
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Immunogenicity of PE18, PE31, and PPE26 proteins from Mycobacterium tuberculosis in humans and mice by García-Bengoa, María, Vergara, Emil Joseph, Tran, Andy C, Bossi, Lorenzo, Cooper, Andrea M, Pearl, John E, Mussá, Tufária, von Köckritz-Blickwede, Maren, Singh, Mahavir, Reljic, Rajko

“…The large family of PE and PPE proteins accounts for as much as 10% of the genome of . In this study, we explored the immunogenicity of three proteins from…”
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ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes by Reiley, William W, Calayag, Mark D, Wittmer, Susan T, Huntington, Jennifer L, Pearl, John E, Fountain, Jeffrey J, Martino, Cynthia A, Roberts, Alan D, Cooper, Andrea M, Winslow, Gary M, Woodland, David L

“…CD4⁺ T cell responses to aerosol Mycobacterium tuberculosis (Mtb) infection are characterized by the relatively delayed appearance of effector T cells in the…”
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Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection by Cruz, Andrea, Khader, Shabaana A, Torrado, Egidio, Fraga, Alexandra, Pearl, John E, Pedrosa, Jorge, Cooper, Andrea M, Castro, António G

“…T cell responses are important to the control of infection but are deleterious if not regulated. IFN-gamma-deficient mice infected with mycobacteria exhibit…”
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Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection by Torrado, Egidio, Fountain, Jeffrey J, Liao, Mingfeng, Tighe, Michael, Reiley, William W, Lai, Rachel P, Meintjes, Graeme, Pearl, John E, Chen, Xinchun, Zak, Daniel E, Thompson, Ethan G, Aderem, Alan, Ghilardi, Nico, Solache, Alejandra, McKinstry, K Kai, Strutt, Tara M, Wilkinson, Robert J, Swain, Susan L, Cooper, Andrea M

“…CD4+ T cells mediate protection against Mycobacterium tuberculosis (Mtb); however, the phenotype of protective T cells is undefined, thereby confounding…”
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Immunological roulette: Luck or something more? Considering the connections between host and environment in TB by Pearl, John E, Das, Mrinal, Cooper, Andrea M

“…Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive, yet…”
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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection by Khader, Shabaana A, Partida-Sanchez, Santiago, Bell, Guy, Jelley-Gibbs, Dawn M, Swain, Susan, Pearl, John E, Ghilardi, Nico, Desauvage, Frederic J, Lund, Frances E, Cooper, Andrea M

“…Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from…”
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IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available by Khader, Shabaana A, Pearl, John E, Sakamoto, Kaori, Gilmartin, Leigh, Bell, Guy K, Jelley-Gibbs, Dawn M, Ghilardi, Nico, deSauvage, Fred, Cooper, Andrea M

“…IL-12p70 induced IFN-gamma is required to control Mycobacterium tuberculosis growth; however, in the absence of IL-12p70, an IL-12p40-dependent pathway…”
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In a Murine Tuberculosis Model, the Absence of Homeostatic Chemokines Delays Granuloma Formation and Protective Immunity by Khader, Shabaana A, Rangel-Moreno, Javier, Fountain, Jeffrey J, Martino, Cynthia A, Reiley, William W, Pearl, John E, Winslow, Gary M, Woodland, David L, Randall, Troy D, Cooper, Andrea M

“…Mycobacterium tuberculosis infection (Mtb) results in the generation of protective cellular immunity and formation of granulomatous structures in the lung…”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on antimicrobial resistance in agrifood systems: An online survey by McIntyre, K. Marie, Khan, Maha, Betson, Martha, Brunton, Lucy, Degiovanni, Hernan Botero, Desbois, Andrew P., Eltholth, Mahmoud, Hurley, Paul, Morgans, Lisa, Pearl, John E., Sakrabani, Ruben, Shortall, Orla, Watson, Katharina, Cole, Jennifer

“…Antimicrobial resistance (AMR) evolution and onward transmission of resistance genes is impacted by interrelated biological and social drivers, with evidence…”
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Discovery of Olivine in the Nili Fossae Region of Mars by Hoefen, Todd M., Clark, Roger N., Bandfield, Joshua L., Smith, Michael D., Pearl, John C., Christensen, Philip R.

“…We have detected a 30,000-square-kilometer area rich in olivine in the Nili Fossae region of Mars. Nili Fossae has been interpreted as a complex of grabens and…”
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Assimilation of thermal emission spectrometer atmospheric data during the Mars Global Surveyor aerobraking period by Lewis, Stephen R., Read, Peter L., Conrath, Barney J., Pearl, John C., Smith, Michael D.

“…The Thermal Emission Spectrometer aboard the Mars Global Surveyor spacecraft has produced an extensive atmospheric data set, beginning during aerobraking and…”
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Balance between Protection and Pathogenic Response to Aerosol Challenge with Mycobacterium tuberculosis (Mtb) in Mice Vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens by Sulman, Sadaf, Savidge, Benjamin O., Alqaseer, Kawther, Das, Mrinal K., Nezam Abadi, Neda, Pearl, John E., Turapov, Obolbek, Mukamolova, Galina V., Akhtar, M. Waheed, Cooper, Andrea May

“…Tuberculosis vaccines capable of reducing disease worldwide have proven difficult to develop. BCG is effective in limiting childhood disease, but adult TB is…”
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Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection by Pearl, John E., Torrado, Egidio, Tighe, Michael, Fountain, Jeffrey J., Solache, Alejandra, Strutt, Tara, Swain, Susan, Appelberg, Rui, Cooper, Andrea M.

“…Animals lacking the inducible nitric oxide synthase gene (nos2−/−) are less susceptible to Mycobacterium avium strain 25291 and lack nitric oxide‐mediated…”
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Thermal Emission Spectrometer results: Mars atmospheric thermal structure and aerosol distribution by Smith, Michael D., Pearl, John C., Conrath, Barney J., Christensen, Philip R.

“…Infrared spectra returned by the Thermal Emission Spectrometer (TES) are well suited for retrieval of the thermal structure and the distribution of aerosols in…”
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IL-27 Signaling Compromises Control of Bacterial Growth in Mycobacteria-Infected Mice by Pearl, John E, Khader, Shabaana A, Solache, Alejandra, Gilmartin, Leigh, Ghilardi, Nico, deSauvage, Fred, Cooper, Andrea M

“…Resistance to tuberculosis (TB) is dependent on the induction of Ag-specific CD4 Th1 T cells capable of expressing IFN-gamma. Generation of these T cells is…”
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