Search Results - "Pearce, Robert"

Changing perspectives on the internationalization of R&D and innovation by multinational enterprises: A review of the literature by Papanastassiou, Marina, Pearce, Robert, Zanfei, Antonello

“…Internationalization of R&D and innovation by multinational enterprises (MNEs) has undergone a gradual and comprehensive change in perspective over the past 50…”
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Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study by Ballweg, Tyler, White, Marissa, Parker, Margaret, Casey, Cameron, Bo, Amber, Farahbakhsh, Zahra, Kayser, Austin, Blair, Alexander, Lindroth, Heidi, Pearce, Robert A, Blennow, Kaj, Zetterberg, Henrik, Lennertz, Richard, Sanders, Robert D

“…Postoperative delirium is associated with increases in the neuronal injury biomarker, neurofilament light (NfL). Here we tested whether two other biomarkers,…”
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Reply to Editorial Comment on “The Yield of Genetic Testing in Management of Nephrolithiasis” by Pearce, Robert J., Sui, Wilson, Yang, Heiko, Chi, Thomas, Stoller, Marshall

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The Yield of Genetic Testing in Management of Nephrolithiasis by Pearce, Robert J., Sui, Wilson, Yang, Heiko, Chi, Thomas, Stoller, Marshall

“…To describe the yield and indications for performing genetic testing in patients with nephrolithiasis. Genetic testing for nephrolithiasis is becoming more…”
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GABAA,slow : causes and consequences by Capogna, Marco, Pearce, Robert A

“…GABAA receptors in the CNS mediate both fast synaptic and tonic inhibition. Over the past decade a phasic current with features intermediate between fast…”
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Diversity of inhibitory neurotransmission through GABA A receptors by Mody, Istvan, Pearce, Robert A.

“…In the brain, highly connected and heterogeneous GABAergic cells are crucial in controling the activity of neuronal networks. They accomplish this task by…”
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httk: R Package for High-Throughput Toxicokinetics by Pearce, Robert G, Setzer, R Woodrow, Strope, Cory L, Wambaugh, John F, Sipes, Nisha S

“…Thousands of chemicals have been profiled by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of…”
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Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions by Honda, Gregory S, Pearce, Robert G, Pham, Ly L, Setzer, R W, Wetmore, Barbara A, Sipes, Nisha S, Gilbert, Jon, Franz, Briana, Thomas, Russell S, Wambaugh, John F

“…Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal…”
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Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award by Pearce, Robert A., Maze, Mervyn

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MNE R&D internationalization in developing Asia by Zhao, Shasha, Papanastassiou, Marina, Pearce, Robert D., Iguchi, Chie

“…In line with the recent shift of R&D internationalization towards developing Asia, this Perspective paper reviews, contextualises, and evaluates the evolving…”
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Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study by Taylor, Jennifer, Parker, Margaret, Casey, Cameron P, Tanabe, Sean, Kunkel, David, Rivera, Cameron, Zetterberg, Henrik, Blennow, Kaj, Pearce, Robert A, Lennertz, Richard C, Sanders, Robert D

“…Case-control studies have associated delirium with blood-brain barrier (BBB) permeability. However, this approach cannot determine whether delirium is…”
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Cohort Analysis of the Association of Delirium Severity With Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies by Parker, Margaret, White, Marissa, Casey, Cameron, Kunkel, David, Bo, Amber, Blennow, Kaj, Zetterberg, Henrik, Pearce, Robert A, Lennertz, Richard, Sanders, Robert D

“…Abstract Delirium is associated with cognitive decline and subsequent dementia, and rises in plasma total tau (tTau) and neurofilament light (NfL), providing…”
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Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness by Ferrarelli, Fabio, Massimini, Marcello, Sarasso, Simone, Casali, Adenauer, Riedner, Brady A, Angelini, Giuditta, Tononi, Giulio, Pearce, Robert A

“…By employing transcranial magnetic stimulation (TMS) in combination with high-density electroencephalography (EEG), we recently reported that cortical…”
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Reduction of Postoperative Cognitive Deficits in Aged Mice by Chronic Intermittent Propofol by Nagarajan, Rajasekar, Lyu, Jinrui, Kambali, Maltesh, Wang, Muxiao, Pearce, Robert A., Rudolph, Uwe

“…Postoperative cognitive dysfunction (POCD) can increase morbidity and mortality after surgery, especially in the elderly. Current evidence from both…”
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Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization by Wambaugh, John F, Wetmore, Barbara A, Ring, Caroline L, Nicolas, Chantel I, Pearce, Robert G, Honda, Gregory S, Dinallo, Roger, Angus, Derek, Gilbert, Jon, Sierra, Teresa, Badrinarayanan, Akshay, Snodgrass, Bradley, Brockman, Adam, Strock, Chris, Setzer, R Woodrow, Thomas, Russell S

“…Abstract High(er) throughput toxicokinetics (HTTK) encompasses in vitro measures of key determinants of chemical toxicokinetics and reverse dosimetry…”
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Diversity of inhibitory neurotransmission through GABAA receptors by MODY, Istvan, PEARCE, Robert A

“…In the brain, highly connected and heterogeneous GABAergic cells are crucial in controling the activity of neuronal networks. They accomplish this task by…”
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Electron beam treatment for the removal of 1,4-dioxane in water and wastewater by Pearce, Robert, Li, Xi, Vennekate, John, Ciovati, Gianluigi, Bott, Charles

“…Electron beam (e-beam) treatment uses accelerated electrons to form oxidizing and reducing radicals when applied to water without the use of external…”
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Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP by Zhu, Mengwen, Perkins, Mark G., Lennertz, Richard, Abdulzahir, Alifayaz, Pearce, Robert A.

“…We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated…”
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Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability by Ring, Caroline L., Pearce, Robert G., Setzer, R. Woodrow, Wetmore, Barbara A., Wambaugh, John F.

“…The thousands of chemicals present in the environment (USGAO, 2013) must be triaged to identify priority chemicals for human health risk research. Most…”
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Distinct EEG signatures differentiate unconsciousness and disconnection during anaesthesia and sleep by Casey, Cameron P, Tanabe, Sean, Farahbakhsh, Zahra, Parker, Margaret, Bo, Amber, White, Marissa, Ballweg, Tyler, Mcintosh, Andrew, Filbey, William, Saalmann, Yuri, Pearce, Robert A, Sanders, Robert D

“…How conscious experience becomes disconnected from the environment, or disappears, across arousal states is unknown. We sought to identify the neural…”
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