Search Results - "Pearce, RE"

Identification and characterization of novel sequence variations in the cytochrome P4502D6 ( ) gene in African Americans by Gaedigk, A, Bhathena, A, Ndjountché, L, Pearce, R E, Abdel-Rahman, S M, Alander, S W, Bradford, L DiAnne, Rogan, P K, Leeder, J Steven

“…Cytochrome P4502D6 (CYP2D6) genotyping reliably predicts poor metabolizer phenotype in Caucasians, but is less accurate in African Americans. To evaluate…”
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Characterization of Cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 Activities toward Model CYP2D6 Substrates Dextromethorphan, Bufuralol, and Debrisoquine by MARCUCCI, Kenda A, PEARCE, Robin E, CRESPI, Charles, STEIMEL, Dorothy T, LEEDER, J. Steven, GAEDIGK, Andrea

“…Over 50 allelic variants of cytochrome P450 2D6 (CYP2D6) encoding fully functional, reduced-activity, or nonfunctional proteins have been described. Compared…”
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The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype by Gaedigk, A, Simon, SD, Pearce, RE, Bradford, LD, Kennedy, MJ, Leeder, JS

“…Inferring CYP2D6 phenotype from genotype is increasingly challenging, considering the growing number of alleles and their range of activity. This complexity…”
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Variability of CYP3A7 expression in human fetal liver by Leeder, J Steven, Gaedigk, Roger, Marcucci, Kenda A, Gaedigk, Andrea, Vyhlidal, Carrie A, Schindel, Bradley P, Pearce, Robin E

“…Fetal liver CYP3A7 plays an important role in placental estriol synthesis during pregnancy, yet little is known concerning the extent or consequences of…”
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Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study by Price, KE, Pearce, RE, Garg, UC, Heese, BA, Smith, LD, Sullivan, JE, Kennedy, MJ, Bale, JF, Ward, RM, Chang, TKH, Abbott, FS, Leeder, JS

“…Young children are at increased risk for valproic acid (VPA) hepatotoxicity. Urinary organic acid profiles, as a surrogate of mitochondrial function, were…”
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PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE by PEARCE, Robin E, UETRECHT, Jack P, LEEDER, J. Steven

“…Conversion of the carbamazepine metabolite, 2-hydroxycarbamazepine, to the potentially reactive species, carbamazepine iminoquinone (CBZ-IQ), has been proposed…”
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Pathways of Carbamazepine Bioactivation in Vitro I. Characterization of Human Cytochromes P450 Responsible for the Formation of 2- and 3-Hydroxylated Metabolites by PEARCE, Robin E, VAKKALAGADDA, Gangadhara R, LEEDER, J. Steven

“…In vitro studies were conducted to identify the cytochromes P450 (P450s) involved in the formation of 2- and 3-hydroxycarbamazepine, metabolites that may serve…”
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Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency by Kennedy, MJ, Davis, DA, Smith, N, Gaedigk, A, Pearce, RE, Kearns, GL

“…Growth hormone (GH) regulates the sex‐specific expression of drug‐metabolizing enzymes (DMEs),1 and it has been shown that the clearance of multi‐enzymatic…”
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Effects of Freezing, Thawing, and Storing Human Liver Microsomes on Cytochrome P450 Activity by Pearce, Robin E., McIntyre, Christin J., Madan, Ajay, Sanzgiri, Uma, Draper, Alison J., Bullock, Peter L., Cook, Dorn C., Burton, L.Alayne, Latham, Jason, Nevins, Cheryl, Parkinson, Andrew

“…The stability of cytochrome P450 enzymes, cytochrome b5, and NADPH–cytochrome c reductase was examined in (A) human liver samples frozen in liquid nitrogen and…”
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Identification of the human P450 enzymes involved in lansoprazole metabolism by Pearce, R E, Rodrigues, A D, Goldstein, J A, Parkinson, A

“…The aim of this study was to identify which human P450 enzymes are involved in the metabolism of lansoprazole. In the presence of NADPH and oxygen, human liver…”
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Cytochrome P450 Involvement in the Biotransformation of Cisapride and Racemic Norcisapride in Vitro: Differential Activity of Individual Human CYP3A Isoforms by PEARCE, Robin E, GOTSCHALL, R. Russell, KEARNS, Gregory L, LEEDER, J. Steven

“…Identification of the human cytochrome P450 (P450) enzymes involved in the metabolism of cisapride and racemic norcisapride [(±)-norcisapride] was…”
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Identification and characterization of novel sequence variations in the cytochrome P4502D6 gene in African Americans by Gaedigk, A, Bhathena, A, Ndjountche, L, Pearce, R E, Abdel-Rahman, S M, Alander, S W, Bradford, L DiAnne, Leeder, J Steven

“…Cytochrome P4502D6 (CYP2D6) genotyping reliably predicts poor metabolizer phenotype in Caucasians, but is less accurate in African Americans. To evaluate…”
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Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes by Lehman-McKeeman, Lois D, Caudill, Douglas, Vassallo, Jeffrey D, Pearce, Robin E, Madan, Ajay, Parkinson, Andrew

“…The purpose of the present work was to characterize the effect of musk xylene (MX) and musk ketone (MK) treatment on rat hepatic cytochrome P450 enzymes. Male…”
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trans-6-Hexadecenoic acid in the spadefish Chaetodipterus faber by Pearce, R E, Stillway, L W

“…Fatty acid methyl esters were prepared from spadefish (Chaetodipterus faber) liver oil and were analyzed by open tublar gas chromatography. The unusual fatty…”
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'Anesthetic' doses of fentanyl by Pearce, R E

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