Search Results - "Pearce, R E"

The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype by Gaedigk, A, Simon, SD, Pearce, RE, Bradford, LD, Kennedy, MJ, Leeder, JS

“…Inferring CYP2D6 phenotype from genotype is increasingly challenging, considering the growing number of alleles and their range of activity. This complexity…”
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Ontogeny of Dextromethorphan O‐ and N‐demethylation in the First Year of Life by Blake, M J, Gaedigk, A, Pearce, R E, Bomgaars, L R, Christensen, M L, Stowe, C, James, L P, Wilson, J T, Kearns, G L, Leeder, J S

“…The exponential increase in the number of drugs used to treat infant and childhood illnesses necessitates an understanding of the ontogeny of drug…”
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Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study by Price, KE, Pearce, RE, Garg, UC, Heese, BA, Smith, LD, Sullivan, JE, Kennedy, MJ, Bale, JF, Ward, RM, Chang, TKH, Abbott, FS, Leeder, JS

“…Young children are at increased risk for valproic acid (VPA) hepatotoxicity. Urinary organic acid profiles, as a surrogate of mitochondrial function, were…”
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Identification and characterization of novel sequence variations in the cytochrome P4502D6 ( ) gene in African Americans by Gaedigk, A, Bhathena, A, Ndjountché, L, Pearce, R E, Abdel-Rahman, S M, Alander, S W, Bradford, L DiAnne, Rogan, P K, Leeder, J Steven

“…Cytochrome P4502D6 (CYP2D6) genotyping reliably predicts poor metabolizer phenotype in Caucasians, but is less accurate in African Americans. To evaluate…”
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PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE by PEARCE, Robin E, UETRECHT, Jack P, LEEDER, J. Steven

“…Conversion of the carbamazepine metabolite, 2-hydroxycarbamazepine, to the potentially reactive species, carbamazepine iminoquinone (CBZ-IQ), has been proposed…”
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Identification and Characterization of CYP2D656B, an Allele Associated with the Poor Metabolizer Phenotype by Gaedigk, A, Eklund, J D, Pearce, R E, Leeder, J S, Alander, S W, Phillips, M S, Bradford, L D, Kennedy, M J

“…A 5‐year‐old African‐American girl presented with a CYP2D6*4xN/*10 genotype that was discordant with her poor metabolizer phenotype determined with the probe…”
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Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children by Dinh, Jean C, Pearce, Robin E, Van Haandel, Leon, Gaedigk, Andrea, Leeder, J Steven

“…Atomoxetine (ATX) is a second-line nonstimulant medication used to control symptoms of attention deficit hyperactivity disorder (ADHD). Inconsistent…”
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Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency by Kennedy, MJ, Davis, DA, Smith, N, Gaedigk, A, Pearce, RE, Kearns, GL

“…Growth hormone (GH) regulates the sex‐specific expression of drug‐metabolizing enzymes (DMEs),1 and it has been shown that the clearance of multi‐enzymatic…”
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Identification of the human P450 enzymes involved in lansoprazole metabolism by Pearce, R E, Rodrigues, A D, Goldstein, J A, Parkinson, A

“…The aim of this study was to identify which human P450 enzymes are involved in the metabolism of lansoprazole. In the presence of NADPH and oxygen, human liver…”
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Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity by Shakhnovich, V., Abdel‐Rahman, S., Friesen, C. A., Weigel, J., Pearce, R. E., Gaedigk, A., Leeder, J. S., Kearns, G. L.

“…Summary Background Children with obesity are more likely to suffer gastroesophageal reflux disease, requiring acid‐suppression therapy with proton pump…”
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Plasma ghrelin and liquid gastric emptying in children with functional dyspepsia consistent with post‐prandial distress syndrome by Hijaz, N. M., Friesen, C. A., Schurman, J. V., Pearce, R. E., Abdel‐Rahman, S. M.

“…Background Adult studies indicate a role for ghrelin in functional dyspepsia (FD) mediated through ghrelin's effect on gastric emptying (GE). This study…”
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The effect of bilayer regions on the response of epitaxial graphene devices to environmental gating by Hill-Pearce, R.E., Eless, V., Lartsev, A., Martin, N.A., Barker Snook, I.L., Helmore, J.J., Yakimova, R., Gallop, J.C., Hao, L.

“…The effect of a bilayer area on the electronic response to environmental gating of a monolayer graphene Hall bar device is investigated using room temperature…”
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Cytochrome P450 Involvement in the Biotransformation of Cisapride and Racemic Norcisapride in Vitro: Differential Activity of Individual Human CYP3A Isoforms by PEARCE, Robin E, GOTSCHALL, R. Russell, KEARNS, Gregory L, LEEDER, J. Steven

“…Identification of the human cytochrome P450 (P450) enzymes involved in the metabolism of cisapride and racemic norcisapride [(±)-norcisapride] was…”
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Effects of Freezing, Thawing, and Storing Human Liver Microsomes on Cytochrome P450 Activity by Pearce, Robin E., McIntyre, Christin J., Madan, Ajay, Sanzgiri, Uma, Draper, Alison J., Bullock, Peter L., Cook, Dorn C., Burton, L.Alayne, Latham, Jason, Nevins, Cheryl, Parkinson, Andrew

“…The stability of cytochrome P450 enzymes, cytochrome b5, and NADPH–cytochrome c reductase was examined in (A) human liver samples frozen in liquid nitrogen and…”
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Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants by Boberg, Mikael, Vrana, Marc, Mehrotra, Aanchal, Pearce, Robin E, Gaedigk, Andrea, Bhatt, Deepak Kumar, Leeder, J Steven, Prasad, Bhagwat

“…The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in human liver was investigated and applied to predict infant…”
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Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation by Pearce, Robin E, Gaedigk, Roger, Twist, Greyson P, Dai, Hongying, Riffel, Amanda K, Leeder, J Steven, Gaedigk, Andrea

“…Although CYP2B6 catalyzes the biotransformation of many drugs used clinically for children and adults, information regarding the effects of development on…”
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Age‐ and Genotype‐Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate‐Glucuronosyltransferases in Human Liver

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Characterization of Cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 Activities toward Model CYP2D6 Substrates Dextromethorphan, Bufuralol, and Debrisoquine by MARCUCCI, Kenda A, PEARCE, Robin E, CRESPI, Charles, STEIMEL, Dorothy T, LEEDER, J. Steven, GAEDIGK, Andrea

“…Over 50 allelic variants of cytochrome P450 2D6 (CYP2D6) encoding fully functional, reduced-activity, or nonfunctional proteins have been described. Compared…”
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Identification and characterization of novel sequence variations in the cytochrome P4502D6 gene in African Americans by Gaedigk, A, Bhathena, A, Ndjountche, L, Pearce, R E, Abdel-Rahman, S M, Alander, S W, Bradford, L DiAnne, Leeder, J Steven

“…Cytochrome P4502D6 (CYP2D6) genotyping reliably predicts poor metabolizer phenotype in Caucasians, but is less accurate in African Americans. To evaluate…”
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Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes by Lehman-McKeeman, Lois D, Caudill, Douglas, Vassallo, Jeffrey D, Pearce, Robin E, Madan, Ajay, Parkinson, Andrew

“…The purpose of the present work was to characterize the effect of musk xylene (MX) and musk ketone (MK) treatment on rat hepatic cytochrome P450 enzymes. Male…”
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