Search Results - "Pearce, Lesley"

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function by Bandala-Sanchez, Esther, Bediaga, Naiara G., Goddard-Borger, Ethan D., Ngui, Katrina, Naselli, Gaetano, Stone, Natalie L., Neale, Alana M., Pearce, Lesley A., Wardak, Ahmad, Czabotar, Peter, Haselhorst, Thomas, Maggioni, Andrea, Hartley-Tassell, Lauren A., Adams, Timothy E., Harrison, Leonard C.

“…CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble form following T cell activation and binds to the Siglec (sialic…”
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Enzyme mediated incorporation of zirconium-89 or copper-64 into a fragment antibody for same day imaging of epidermal growth factor receptor by Rudd, Stacey E, Van Zuylekom, Jessica K, Raicevic, Anna, Pearce, Lesley A, Cullinane, Carleen, Williams, Charlotte C, Adams, Timothy E, Hicks, Rodney J, Donnelly, Paul S

“…Identification of tumors which over-express Epidermal Growth Factor Receptor (EGFR) is important in selecting patients for anti-EGFR therapies. Enzymatic…”
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Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π‑Clamp Conjugation by Lee, Michael D, Tong, Wing Yin, Nebl, Thomas, Pearce, Lesley A, Pham, Tam M, Golbaz-Hagh, Arghavan, Puttick, Simon, Rose, Stephen, Adams, Timothy E, Williams, Charlotte C

“…The functionalization of proteins with different cargo molecules is highly desirable for a broad range of applications. However, the reproducible production of…”
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Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer by He, Yaowu, Khan, Tashbib, Kryza, Thomas, Jones, Martina L, Goh, Justin B, Lyons, Nicholas J, Pearce, Lesley A, Lee, Michael D, Gough, Madeline, Rogers, Rebecca, Davies, Claire M, Gilks, C. Blake, Hodgkinson, Thomas, Lourie, Rohan, Barry, Sinead C, Perrin, Lewis C, Williams, Charlotte C, Puttick, Simon, Adams, Timothy E, Munro, Trent P, Hooper, John D, Chetty, Naven

“…Optimal cytoreduction for ovarian cancer is often challenging because of aggressive tumor biology and advanced stage. It is a critical issue since the extent…”
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Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by sortase A-mediated protein ligation by Madej, Mariusz P., Coia, Gregory, Williams, Charlotte C., Caine, Joanne M., Pearce, Lesley A., Attwood, Rebecca, Bartone, Nick A., Dolezal, Olan, Nisbet, Rebecca M., Nuttall, Stewart D., Adams, Timothy E.

“…Sortase‐mediated protein ligation is a biological covalent conjugation system developed from the enzymatic cell wall display mechanism found in Staphylococcus…”
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Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2 by Watterson, Daniel, Wijesundara, Danushka K, Modhiran, Naphak, Mordant, Francesca L, Li, Zheyi, Avumegah, Michael S, McMillan, Christopher LD, Lackenby, Julia, Guilfoyle, Kate, Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey TM, Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L, Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam, Zhou, Qi, Brockman, David A, Morgan, Sherry J, Lau, Cora, Tran, Mai H, Tapley, Peter, Villalón‐Letelier, Fernando, Barnes, James, Young, Andrew, Jaberolansar, Noushin, Scott, Connor AP, Isaacs, Ariel, Amarilla, Alberto A, Khromykh, Alexander A, Brand, Judith MA, Reading, Patrick C, Ranasinghe, Charani, Subbarao, Kanta, Munro, Trent P, Young, Paul R, Chappell, Keith J

“…Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we…”
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Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer by Greenall, Sameer A., Bentley, John D., Pearce, Lesley A., Scoble, Judith A., Sparrow, Lindsay G., Bartone, Nicola A., Xiao, Xiaowen, Baxter, Robert C., Cosgrove, Leah J., Adams, Timothy E.

“…Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I…”
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CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy by Khan, Tashbib, Lyons, Nicholas J, Gough, Madeline, Kwah, Kayden K X, Cuda, Tahleesa J, Snell, Cameron E, Tse, Brian W, Sokolowski, Kamil A, Pearce, Lesley A, Adams, Timothy E, Rose, Stephen E, Puttick, Simon, Pajic, Marina, Adams, Mark N, He, Yaowu, Hooper, John D, Kryza, Thomas

“…An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein enriched on…”
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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide by Nisbet, Rebecca M., Nuttall, Stewart D., Robert, Remy, Caine, Joanne M., Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A., Davydova, Natalia, Masters, Colin L., Varghese, Jose N., Streltsov, Victor A.

“…ABSTRACT Alzheimer's disease is the most common form of dementia in humans and is related to the accumulation of the amyloid‐β (Aβ) peptide and its interaction…”
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Structural characterization by transmission electron microscopy and immunoreactivity of recombinant Hendra virus nucleocapsid protein expressed and purified from Escherichia coli by Pearce, Lesley A., Yu, Meng, Waddington, Lynne J., Barr, Jennifer A., Scoble, Judith A., Crameri, Gary S., McKinstry, William J.

“…•Recombinant HeV N was expressed in a soluble from in E. coli.•HeV N purified by IMAC and SEC formed higher order oligomers.•Negative-stain EM images of…”
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Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment by Robert, Remy, Streltsov, Victor A., Newman, Janet, Pearce, Lesley A., Wark, Kim L., Dolezal, Olan

“…Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Aβ peptide (39–43 amino acids) derived from the proteolytic…”
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Kinetic screening of antibody–Im7 conjugates by capture on a colicin E7 DNase domain using optical biosensors by Hosse, Ralf J., Tay, Leigh, Hattarki, Meghan K., Pontes-Braz, Luisa, Pearce, Lesley A., Nuttall, Stewart D., Dolezal, Olan

“…Antibody generation by phage display and related in vitro display technologies routinely yields large panels of clones detected in primary end-point screenings…”
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Detection of filovirus-reactive antibodies in Australian bat species by Barr, Jennifer, Boyd, Victoria, Todd, Shawn, Smith, Ina, Prada, Diana, O'Dea, Mark, Jackson, Bethany, Pearce, Lesley, Adams, Timothy E., Vanderduys, Eric, Westcott, David, McKeown, Adam, Baker, Michelle L., Marsh, Glenn A.

“…Bats have been implicated as the reservoir hosts of filoviruses in Africa, with serological evidence of filoviruses in various bat species identified in other…”
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Development and preliminary validation of a MERS-CoV ELISA for serological testing of camels and alpacas by McNabb, Leanne, Durr, Peter A., Lunt, Ross, Barr, Jennifer, Adams, Timothy E., Pearce, Lesley, Poon, Leo L.M., Perera, Ranawaka AP M., Demissie, Getnet Fekadu, Bowden, Timothy R.

“…This study describes the development and preliminary validation of a new serological assay using MERS-CoV S1 protein in an indirect enzyme-linked immunosorbent…”
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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma by Greenall, Sameer A, McKenzie, Mathew, Seminova, Ekatarina, Dolezal, Olan, Pearce, Lesley, Bentley, John, Kuchibhotla, Mani, Chen, Shengnan C, McDonald, Kerrie L, Kornblum, Harley I, Endersby, Raelene, Adams, Timothy E, Johns, Terrance G

“…Although epidermal growth factor receptor (EGFR) and its truncated, autoactive mutant EGFR variant (v)III are bona fide drivers of tumorigenesis in some…”
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Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses by Vaz, Paola K, Hartley, Carol A, Lee, Sang-Yong, Sansom, Fiona M, Adams, Timothy E, Stalder, Kathryn, Pearce, Lesley, Lovrecz, George, Browning, Glenn F, Müller, Christa E, Devlin, Joanne M

“…There is a large taxonomic gap in our understanding of mammalian herpesvirus genetics and evolution corresponding to those herpesviruses that infect…”
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ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in VL to VH orientation drives the formation of dimers, trimers, tetramers and higher molecular mass multimers by Dolezal, Olan, Pearce, Lesley A., Lawrence, Lynne J., McCoy, Airlie J., Hudson, Peter J., Kortt, Alexander A.

“…Synthetic genes encoding single-chain variable fragments (scFvs) of NC10 anti-neuraminidase antibody were constructed by joining the VL and VH domains with…”
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Abstract WP187: Correlation between Infarct Shape and Volume and Ischemic Risk Factors and Recurrent Ischemic Rates in Small Subcortical Stroke; Data from the SPS3 Randomized Controlled Trial by Asdaghi, Negar, Pearce, Lesley, Nakajima, Makoto, Bazan, Carlos, Cermeno, Franco, Lewis, Brandy, Hart, Robert G, Benavente, Oscar

“…Abstract only Background: Most of lacunar infarcts (LI) are due to penetrating small vessel disease, although other mechanisms can be responsible for LI. We…”
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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide: Aβ N-Terminal Structural Studies by Nisbet, Rebecca M., Nuttall, Stewart D., Robert, Remy, Caine, Joanne M., Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A., Davydova, Natalia, Masters, Colin L., Varghese, Jose N., Streltsov, Victor A.

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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-[beta] peptide by Nisbet, Rebecca M, Nuttall, Stewart D, Robert, Remy, Caine, Joanne M, Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A, Davydova, Natalia, Masters, Colin L, Varghese, Jose N, Streltsov, Victor A

“…Alzheimer's disease is the most common form of dementia in humans and is related to the accumulation of the amyloid-[beta] (A[beta]) peptide and its…”
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