Search Results - "Pearce, Laurence"

Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): Technical recommendations for the use of Short Tandem Repeat (STR) based techniques, on behalf of the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping Chimerism Working Group by Clark, Jordan R., Scott, Stuart D., Jack, Andrea L., Lee, Helena, Mason, Joanne, Carter, Geoffrey I., Pearce, Laurence, Jackson, Tony, Clouston, Hazel, Sproul, Anne, Keen, Leigh, Molloy, Karen, Folarin, Najeem'deen, Whitby, Liam, Snowden, John A., Reilly, John T., Barnett, David

“…Summary Analysis of short tandem repeats (STR) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection of…”
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Measurement of Vital Signs by Lifelight Software in Comparison to Standard of Care Multisite Development (VISION-MD): Protocol for an Observational Study by Wiffen, Laura, Brown, Thomas, Brogaard Maczka, Annika, Kapoor, Melissa, Pearce, Laurence, Chauhan, Milan, Chauhan, Anoop J, Saxena, Manish

“…Measuring vital signs (VS) is an important aspect of clinical care but is time-consuming and requires multiple pieces of equipment and trained staff. Interest…”
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Measurement of Vital Signs Using Lifelight Remote Photoplethysmography: Results of the VISION-D and VISION-V Observational Studies by Heiden, Emily, Jones, Tom, Brogaard Maczka, Annika, Kapoor, Melissa, Chauhan, Milan, Wiffen, Laura, Barham, Helen, Holland, Jeremy, Saxena, Manish, Wegerif, Simon, Brown, Thomas, Lomax, Mitch, Massey, Heather, Rostami, Shahin, Pearce, Laurence, Chauhan, Anoop

“…Background The detection of early changes in vital signs (VSs) enables timely intervention; however, the measurement of VSs requires hands-on technical…”
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Outcomes of alemtuzumab‐based reduced intensity conditioning stem cell transplantation using unrelated donors for myelodysplastic syndromes by Lim, Zi Yi, Ho, Aloysius Y. L., Ingram, Wendy, Kenyon, Michelle, Pearce, Laurence, Czepulkowski, Barbara, Devereux, Stephen, Duarte, Rafael F., Pagliuca, Antonio, Mufti, Ghulam J.

“…Summary This prospective study evaluated the outcomes of 75 successive patients receiving a FBC (fludarabine, busulphan, alemtuzumab) reduced‐intensity…”
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Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab by Matthews, Katie, Lim, ZiYi, Afzali, Behdad, Pearce, Laurence, Abdallah, Atiyeh, Kordasti, Shahram, Pagliuca, Antonio, Lombardi, Giovanna, Madrigal, J. Alejandro, Mufti, Ghulam J, Barber, Linda D

“…1 The Anthony Nolan Research Institute, Royal Free Hospital, London; 2 Department of Haematological Medicine, King’s College London Denmark Hill Campus, London…”
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Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38 by PEARCE, Laurence, MORGAN, Liam, THET THET LIN, HEWAMANA, Saman, MATTHEWS, R. James, DEAGLIO, Silvia, ROWNTREE, Clare, FEGAN, Christopher, PEPPER, Christopher, BRENNAN, Paul

“…Studies of the role of individual genes in chronic lymphocytic leukemia (CLL) have been hampered by the inability to consistently transfect primary tumor…”
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The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells by Tonks, Alex, Pearn, Lorna, Tonks, Amanda J., Pearce, Laurence, Hoy, Terry, Phillips, Sarah, Fisher, Janet, Downing, James R., Burnett, Alan K., Darley, Richard L.

“…The t(8;21) translocation, which encodes the AML1-ETO fusion protein (now known as RUNX1-CBF2T1), is one of the most frequent translocations in acute myeloid…”
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Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells by Hamilton, Emma, Pearce, Laurence, Morgan, Liam, Robinson, Sophie, Ware, Vicki, Brennan, Paul, Thomas, N. Shaun B., Yallop, Deborah, Devereux, Stephen, Fegan, Chris, Buggins, Andrea G. S., Pepper, Chris

“…Summary Interactions in the tumour microenvironment can promote chronic lymphocytic leukaemia (CLL) cell survival, proliferation and drug resistance. A…”
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Developing the Accuracy of Vital Sign Measurements Using the Lifelight Software Application in Comparison to Standard of Care Methods: Observational Study Protocol by Jones, Thomas L, Heiden, Emily, Mitchell, Felicity, Fogg, Carole, McCready, Sharon, Pearce, Laurence, Kapoor, Melissa, Bassett, Paul, Chauhan, Anoop J

“…Vital sign measurements are an integral component of clinical care, but current challenges with the accuracy and timeliness of patient observations can impact…”
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Effects on erythropoiesis of alemtuzumab‐containing reduced intensity and standard conditioning regimens by Mijovic, Aleksandar, Abdallah, Atiyeh, Pearce, Laurence, Tobal, Khalid, Mufti, Ghulam J.

“…Summary Haemopoietic cell transplantation (HCT) with reduced‐intensity conditioning (RIC) has been associated with delayed disappearance of host anti‐A and…”
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Delayed attainment of full donor chimaerism following alemtuzumab‐based reduced‐intensity conditioning haematopoeitic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes is associated with improved outcomes by Lim, Zi Yi, Pearce, Laurence, Ho, Aloysius Y., Barber, Linda, Ingram, Wendy, Usai, Monica, Tobal, Khalid, Devereux, Stephen, Pagliuca, Antonio, Mufti, Ghulam J.

“…Summary This prospective study evaluated the kinetics of lymphoid (CD3) engraftment in 110 patients with acute myeloid leukaemia (AML) and myelodysplastic…”
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Rapid recovery of lymphocyte subsets is not associated with protection from relapse of myelodysplastic syndromes and acute myeloid leukaemia after haematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab by Matthews, Katie, Lim, ZiYi, Pearce, Laurence, Pagliuca, Antonio, Alejandro Madrigal, J., Mufti, Ghulam J., Barber, Linda D.

“…Summary Graft‐versus‐leukaemia (GvL) and graft‐versus‐host disease (GvHD) are both caused by alloreactive lymphocytes. We previously reported that GvHD…”
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Elucidating the functional role of CD38 in chronic lymphocytic leukaemia by Pearce, Laurence

“…In this study, I applied a range of techniques in an attempt to enhance our knowledge of the role that CD38 plays in the pathogenesis of CLL. Investigation of…”
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Two Distinct Co-Culture Systems, Designed to Mimic the Tumor Microenvironment, Induce Remarkably Similar Phenotypic Changes in Primary CLL Cells by Buggins, Andrea Gail Sherman, Pearce, Laurence, Patten, Piers EM, Morgan, Liam, Brennan, Paul, Fegan, Chris, Devereux, Stephen, Pepper, Chris J

“…Abstract 2362 Poster Board II-339 There is growing evidence that interactions in the tumour microenvironment promote the survival, proliferation and drug…”
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Increased Effector CD4+ T-Cells Early Post Hematopoietic Stem Cell Transplantation Using an Alemtuzumab-Based Reduced Intensity Conditioning Regimen Correlate with Subsequent Development of Graft Versus Host Disease by Matthews, Katie, Lim, ZiYi, Pearce, Laurence, Tobal, Khalid, Madrigal, Alejandro, Mufti, Ghulam J., Barber, Linda D.

“…Lymphocyte depletion using the anti CD52 monoclonal antibody alemtuzumab reduces the incidence of graft versus host disease (GvHD) after allogeneic…”
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Progression Free Survival (PFS) in Alemtuzumab Based RIC Allogeneic Transplantation for Myeloma Is Improved with Use of Pre-Emptive DLI (pDLI) by Ramasamy, Karthik, Mahmood, Shameem, Pearce, Laurence, Lim, ZiYi, Ladon, Dariusz, Pagliuca, Antonio, Devereux, Stephen, Mufti, Ghulam J., Schey, Stephen

“…Allogeneic transplantation is the only potentially curative treatment option for myeloma (MM). While reduced intensity conditioning (RIC) regimens are…”
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Use of Intravenous Busulphan for Reduced Intensity Conditioning (RIC) Haematopoietic Stem Cell Transplantation (HSCT) Is Associated with Delayed T-Cell Full Donor Chimerism and Lower Incidence of Acute Graft Versus Host Disease by Lim, ZiYi, Thanigaikumar, Murugaiyan, Gandhi, Shreyans, Pearce, Laurence, Kenyon, Michelle, Ho, Aloysius Y.L., Devereux, Stephen, Pagliuca, Antonio, Mufti, Ghulam J.

“…The use of IV busulphan (Bu) has reported improved bioavailability with lower variability of busulphan plasma levels, and may reduce the effects of transplant…”
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In-Situ Proliferation May Explain the Persistence of Host Derived Langerhans Cells Following Allogeneic Hematopoietic Stem Cell Transplantation with Reduced Intensity Conditioning by Richards, Julie, Pearce, Laurence, Patten, Piers E.M., Buggins, Andrea G.S., Ho, Aloyisius Y., Pagliuca, Anthony, Mufti, Ghulam J., Devereux, Stephen

“…Langerhans cells (LCs) are antigen presenting cells found in the epidermis. They are thought to originate from bone marrow precursors although studies in mice…”
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The Pattern of T-Cell Donor Chimerism Is a Key Predictor of Outcome Following Alemtuzumab Based Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for MDS and AML by Lim, ZiYi, Pearce, Laurence, Ho, Aloysius Y.L., Barber, Linda, Ingram, Wendy, Usai, Monica, Devereux, Stephen, Pagliuca, Antonio, Mufti, Ghulam

“…In animal models, a mixed lymphohematopoietic chimerism can be achieved after both myeloablative and non-myeloablative conditioning, establishing bidirectional…”
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Use of Pre-Emptive Donor Lymphocyte Infusions To Achieve Durable Remission Following Alemtuzumab Based Reduced Intensity Conditioning (RIC) Transplantation for AML or MDS by Lim, ZiYi, Pearce, Laurence, Ingram, Wendy, Duarte, Rafael, Devereux, Stephen, Pagliuca, Antonio, Ho, Aloysius, Mufti, Ghulam

“…Use of alemtuzumab in RIC HSCT reduces the incidence of graft rejection and graft vs host disease(GvHD). However, there can be a delay in full T-cell donor…”
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