Search Results - "Pearce, EJ"

The immunobiology of schistosomiasis by Pearce, Edward J, MacDonald, Andrew S

“…Schistosomes are parasitic worms that are a prime example of a complex multicellular pathogen that flourishes in the human host despite the development of a…”
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CD25+CD4+ Cells Contribute to Th2 Polarization during Helminth Infection by Suppressing Th1 Response Development by McKee, Amy S, Pearce, Edward J

“…Mice infected with Schistosoma mansoni develop polarized Th2 responses in which Th1 responses are prevented by IL-10-mediated suppression of IL-12 production…”
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Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth by Correnti, Jason M., Brindley, Paul J., Pearce, Edward J.

“…Schistosoma mansoni is an important flatworm parasite of man that has remained intractable to experimental analyses of gene function. We have developed an…”
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Priming of the immune response by schistosome eggs by PEARCE, E. J.

“…SUMMARY Schistosomiasis mansoni is a chronic disease caused by infection with helminths of the genus Schistosoma mansoni. Adult schistosomes live…”
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Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of L-Arginine Metabolism by Hesse, Matthias, Modolell, Manuel, La Flamme, Anne C, Schito, Marco, Fuentes, Jose Manuel, Cheever, Allen W, Pearce, Edward J, Wynn, Thomas A

“…Type 2 cytokines regulate fibrotic liver pathology in mice infected with Schistosoma mansoni. Switching the immune response to a type 1-dominant reaction has…”
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Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses by Cervi, Laura, MacDonald, Andrew S, Kane, Colleen, Dzierszinski, Florence, Pearce, Edward J

“…To examine the ability of dendritic cells (DC) to discriminate between helminth and microbial Ag and induce appropriately polarized Th responses, mouse DC were…”
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Helminth Antigens Modulate TLR-Initiated Dendritic Cell Activation by Kane, Colleen M, Cervi, Laura, Sun, Jie, McKee, Amy S, Masek, Katherine S, Shapira, Sagi, Hunter, Christopher A, Pearce, Edward J

“…There is increasing awareness that helminth infections can ameliorate proinflammatory conditions. In part, this is due to their inherent ability to induce Th2…”
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Th2 response polarization during infection with the helminth parasite Schistosoma mansoni by Pearce, Edward J., M. Kane, Colleen, Sun, Jie, J. Taylor, Justin, McKee, Amy S., Cervi, Laura

“…T‐helper 2 (Th2) cell responses play a critical role in protection against helminth infections. In the case of Schistosoma mansoni, an important helminth…”
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CD8- Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development by MacDonald, Andrew S, Straw, Amy D, Bauman, Beverley, Pearce, Edward J

“…Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8- DC pulsed with…”
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Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii by McKee, Amy S, Dzierszinski, Florence, Boes, Marianne, Roos, David S, Pearce, Edward J

“…Despite its noted ability to induce strong cellular immunity, and its known susceptibility to IFN-gamma-dependent immune effector mechanisms, the protozoan…”
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Immunology of parasitic helminth infections by MACDONALD, Andrew S, ARAUJO, Maria Ilma, PEARCE, Edward J

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Progress towards a vaccine for schistosomiasis by Pearce, Edward J.

“…Schistosomiasis continues to be a significant health problem, especially in Africa. While the recent World Health Assembly resolution to apply mass drug…”
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Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40 by MacDonald, Andrew S, Straw, Amy D, Dalton, Nicole M, Pearce, Edward J

“…We investigated the influence of dendritic cell (DC) CD40 expression on Th2 and Th1 development by in vivo transfer of Ag-pulsed bone marrow-derived DC…”
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TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development by Sun, Jie, Walsh, Matthew, Villarino, Alejandro V, Cervi, Laura, Hunter, Christopher A, Choi, Yongwon, Pearce, Edward J

“…During infection, CD4(+) Th cell responses polarize to become primarily Th1 or Th2. Th1 cells, which make IFN-gamma, are crucial for immunity to many bacterial…”
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Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells by MacDonald, Andrew S, Pearce, Edward J

“…To assess the influence of dendritic cell (DC) production of polarizing cytokines on Th2 and Th1 development we transferred Ag-pulsed DC generated from…”
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Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni by de Jesus, Amelia Ribeiro, Silva, Angela, Santana, Luciana B., Magalhães, Andrea, de Jesus, Adriana Almeida, de Almeida, Roque Pacheco, Rêgo, Marco A. V., Burattini, Marcelo N., Pearce, Edward J., Carvalho, Edgar M.

“…Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear…”
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Evidence that the reduced surface antigenicity of developing Schistosoma mansoni schistosomula is due to antigen shedding rather than host molecule acquisition by Pearce, E J, Basch, P F, Sher, A

“…Antibody and lectin binding characteristics of Schistosoma mansoni schistosomula maturing in vivo and in vitro were quantitatively assessed and compared in…”
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Transgene expression in Schistosoma mansoni: introduction of RNA into schistosomula by electroporation by Correnti, Jason M., Pearce, Edward J.

“…Despite their significance in human and veterinary medicine, and the ability to maintain the parasites in the mouse, relatively little functional detail is…”
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Human transforming growth factor-beta activates a receptor serine/threonine kinase from the intravascular parasite Schistosoma mansoni by Beall, M J, Pearce, E J

“…The biology of the helminth parasite Schistosoma mansoni is closely integrated with that of its mammalian host. SmRK1, a divergent type I transforming growth…”
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Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation by Artis, David, Kane, Colleen M, Fiore, James, Zaph, Colby, Shapira, Sagi, Joyce, Karen, Macdonald, Andrew, Hunter, Christopher, Scott, Phillip, Pearce, Edward J

“…A number of receptors and signaling pathways can influence the ability of dendritic cells (DC) to promote CD4(+) Th type 1 (Th1) responses. In contrast, the…”
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