Search Results - "Pearce, E. J."

Priming of the immune response by schistosome eggs by PEARCE, E. J.

“…SUMMARY Schistosomiasis mansoni is a chronic disease caused by infection with helminths of the genus Schistosoma mansoni. Adult schistosomes live…”
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Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of L-Arginine Metabolism by Hesse, Matthias, Modolell, Manuel, La Flamme, Anne C, Schito, Marco, Fuentes, Jose Manuel, Cheever, Allen W, Pearce, Edward J, Wynn, Thomas A

“…Type 2 cytokines regulate fibrotic liver pathology in mice infected with Schistosoma mansoni. Switching the immune response to a type 1-dominant reaction has…”
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CD8- Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development by MacDonald, Andrew S, Straw, Amy D, Bauman, Beverley, Pearce, Edward J

“…Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8- DC pulsed with…”
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Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter by Reese, T. A., Wakeman, B. S., Choi, H. S., Hufford, M. M., Huang, S. C., Zhang, X., Buck, M. D., Jezewski, A., Kambal, A., Liu, C. Y., Goel, G., Murray, P. J., Xavier, R. J., Kaplan, M. H., Renne, R., Speck, S. H., Artyomov, M. N., Pearce, E. J., Virgin, H. W.

“…Mammals are coinfected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the…”
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Nitric Oxide and the Th2 Response Combine to Prevent Severe Hepatic Damage During Schistosoma mansoni Infection by Brunet, L. Rosa, Beall, M, Dunne, D. W, Pearce, E. J

“…During infection with Schistosoma mansoni, NO production increases following the deposition of parasite eggs in the liver. In wild-type C57BL/6 mice, NO levels…”
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Downregulation of Th1 cytokine production accompanies induction of Th2 responses by parasitic helminth, Schistosoma mansoni by PEARCE, E. J, CASPAR, P, GRZYCH, J.-M, LEWIS, F. A, SHER, A

“…In the mouse, infection with Schistosoma mansoni results in an egg-producing infection and associated disease, whereas vaccination with attenuated larval…”
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Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni by SABIN, E. A, ARAUJO, M. I, CARVALHO, E. M, PEARCE, E. J

“…After vaccination with tetanus toxoid (TT), TT-specific immune responses in humans infected with Schistosoma mansoni were assessed. Peripheral blood…”
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IL-4 Plays a Crucial Role in Regulating Oxidative Damage in the Liver During Schistosomiasis by La Flamme, Anne Camille, Patton, Elisabeth A, Bauman, Beverley, Pearce, Edward J

“…Liver enlargement and hepatocyte proliferation, normal responses in wild-type (WT) mice infected with the parasitic helminth Schistosoma mansoni, were found to…”
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The immunobiology of schistosomiasis by Pearce, Edward J, MacDonald, Andrew S

“…Schistosomes are parasitic worms that are a prime example of a complex multicellular pathogen that flourishes in the human host despite the development of a…”
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Semicrystalline Polymers via Ring-Opening Polymerization:  Preparation and Polymerization of Alkylene Phthalate Cyclic Oligomers by Brunelle, Daniel J, Bradt, Jean E, Serth-Guzzo, Judith, Takekoshi, Tohru, Evans, Thomas L, Pearce, Eric J, Wilson, Paul R

“…Preparation of cyclic oligomeric alkylene phthalates via pseudo-high dilution condensation of alkylene diols with iso- and terephthaloyl chlorides and…”
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Induction of Protective Immunity against Schistosoma mansoni by Vaccination with Schistosome Paramyosin (Sm97), a Nonsurface Parasite Antigen by Pearce, E. J., James, S. L., Hieny, S., Lanar, D. E., Sher, A.

“…Paramyosin (Sm97), a 97-kDa myofibrillar protein identified by the unusually monospecific antibody response induced by intradermal vaccination of mice with a…”
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Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen by Kullberg, MC, Pearce, EJ, Hieny, SE, Sher, A, Berzofsky, JA

“…Schistosoma mansoni infection in the mouse has been shown to be accompanied by a down-regulation in parasite-Ag- and mitogen-induced Th1 cytokine secretion…”
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Imaging trematode and nematode parasites by Pearce, E. J., Lok, J. B.

“…Summary Recent advances in molecular genetics and in imaging mean that it is now increasingly feasible to image biological processes within helminth parasites…”
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Interleukin-12 promotes pathologic liver changes and death in mice coinfected with Schistosoma mansoni and Toxoplasma gondii by ARAUJO, Maria Ilma, BLISS, Susan K, SUZUKI, Yasuhiro, ALCARAZ, Ana, DENKERS, Eric Y, PEARCE, Edward J

“…We previously demonstrated that mice concurrently infected with Schistosoma mansoni and Toxoplasma gondii undergo accelerated mortality which is preceded by…”
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IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni by Oswald, IP, Caspar, P, Jankovic, D, Wynn, TA, Pearce, EJ, Sher, A

“…In the mouse, infection with the helminth parasite Schistosoma mansoni results in the selective induction of CD4+ T lymphocytes belonging to the Th2 subset…”
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Role of Gamma Interferon in the Pathogenesis of Severe Schistosomiasis in Interleukin-4-Deficient Mice by LA FLAMME, Anne Camille, PATTON, Elisabeth A, PEARCE, Edward J

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The use of human faeces for fertilizer is associated with increased intensity of hookworm infection in Vietnamese women by Humphries, D.L., Stephenson, L.S., Pearce, E.J., The, P.H., Dan, H.T., Khanh, L.T.

“…To investigate different factors associated with hookworm infections we conducted 2 studies in a commune in northern Viet Nam. The first was part of a larger…”
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Central Role for Interleukin-4 in Regulating Nitric Oxide-Mediated Inhibition of T-Cell Proliferation and Gamma Interferon Production in Schistosomiasis by PATTON, Elisabeth A, LA FLAMME, Anne C, PEDRAS-VASONCELOS, Joao A, PEARCE, Edward J

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Reverse genetics and the study of the immune response to schistosomes by PEARCE, E.J, FREITAS, T.C

“…The sequencing of the schistosome genome and the establishment of techniques for RNAi and transient transfection in these parasites have opened the door for a…”
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Interferon-gamma production by peripheral blood mononuclear cells from residents of an area endemic for Schistosoma mansoni by Viana, I R, Sher, A, Carvalho, O S, Massara, C L, Eloi-Santos, S M, Pearce, E J, Colley, D G, Gazzinelli, G, Correa-Oliveira, R

“…During human schistosomiasis host responses to antigens of various parasite life-cycle stages may contribute to whether the severe, hepatosplenic state…”
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