Search Results - "Peñalva, M A"

Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety by Orejas, M, Espeso, E A, Tilburn, J, Sarkar, S, Arst, Jr, H N, Peñalva, M A

“…Extremes of pH are an occupational hazard for many microorganisms. In addition to efficient pH homeostasis, survival effectively requires a regulatory system…”
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pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene by Espeso, E.A., Tilburn, J., Arst, H.N., Peñalva, M.A.

“…Transcription of the ipnA gene encoding isopenicillin N synthetase, an enzyme of secondary metabolism, is under the control of the pH regulatory system in the…”
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Carbon catabolite repression can account for the temporal pattern of expression of a penicillin biosynthetic gene in Aspergillus nidulans by Espeso, E A, Peñalva, M A

“…Aspergillus nidulans synthesizes penicillins as secondary metabolites when grown under certain culture conditions. Broths containing carbon (C) sources that…”
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A lacZ reporter fusion method for the genetic analysis of regulatory mutations in pathways of fungal secondary metabolism and its application to the Aspergillus nidulans penicillin pathway by Perez-esteban, B. (Centro de Investigaciones Biologicas del Consejo Superior de Investigaciones Cientificas, Madrid, Spain.), Gomez-Pardo, E, Penalva, M.A

“…Secondary metabolism, usually superfluous under laboratory conditions, is intrinsically elusive to genetic analysis of its regulation. We describe here a…”
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Structural and functional analysis of mutations in alkaptonuria by RODRIGUEZ, José M, TIMM, David E, TITUS, Gregory P, BELTRAN-VALERO DE BERNABE, D, CRIADO, O, MUELLER, Heather A, RODRIGUEZ DE CORDOBA, S, PENALVA, M. A

“…Alkaptonuria (AKU), the prototypic inborn error of metabolism, was the first human disease to be interpreted as a Mendelian trait by Garrod and Bateson at the…”
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Molecular characterization of a fungal secondary metabolism promoter: transcription of the Aspergillus nidulans isopenicillin N synthetase gene is modulated by upstream negative elements by Pérez-Esteban, B, Orejas, M, Gómez-Pardo, E, Peñalva, M A

“…The Aspergillus nidulans IPNS gene, encoding isopenicillin N synthetase, is a secondary metabolism gene. It is contiguous to, but divergently transcribed from,…”
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Reduced Function of a Phenylacetate-Oxidizing Cytochrome P450 Caused Strong Genetic Improvement in Early Phylogeny of Penicillin-Producing Strains by Rodriguez-Saiz, M, Barredo, J L, Moreno, MA, Fernandez-Canon, J M, Penalva, MA, Diez, B

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans by Ramón, D, Carramolino, L, Patiño, C, Sánchez, F, Peñalva, M A

“…Genomic clones containing an Aspergillus nidulans isopenicillin N synthetase (IPNS) gene have been identified by heterologous hybridization with a…”
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Carbon regulation of penicillin biosynthesis in Aspergillus nidulans: a minor effect of mutations in creB and creC by Espeso, E A, Fernández-Cañón, J M, Peñalva, M A

“…Transcription of the Aspergillus nidulans ipnA gene is under carbon regulation. Loss-of-function mutations in creB or creC do not cause full derepression of…”
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The molecular basis of alkaptonuria by Granadino, Begoña, Fernández-Cañón, José M, De Córdoba, Santiago Rodríguez, De Bernabé, Daniel Beltrán-Valero, Renedo, Mónica, Fernández-Ruiz, Elena, Peñalva, Miguel A

“…Alkaptonuria (AKU) occupies a unique place in the history of human genetics because it was the first disease to be interpreted as a mendelian recessive trait…”
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Ambient pH Signaling Regulates Nuclear Localization of the Aspergillus nidulans PacC Transcription Factor by Mingot, J M, Espeso, E A, Díez, E, Peñalva, M A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterisation of the gene encoding acetyl-CoA synthetase in Penicillium chrysogenum: conservation of intron position in plectomycetes by Martínez-Blanco, H, Orejas, M, Reglero, A, Luengo, J M, Peñalva, M A

“…Acetyl-coenzyme A synthetase (ACS; EC 6.2.1.1) from some plectomycete fungi is possibly involved in an accessory step of penicillin biosynthesis, in addition…”
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Mutation and Polymorphism Analysis of the Human Homogentisate 1,2-Dioxygenase Gene in Alkaptonuria Patients by Beltrán-Valero de Bernabé, D., Granadino, B., Chiarelli, I., Porfirio, B., Mayatepek, E., Aquaron, R., Moore, M.M., Festen, J.J.M., Sanmartí, R., Peñalva, M.A., Rodríguez de Córdoba, S.

“…Alkaptonuria (AKU), a rare hereditary disorder of phenylalanine and tyrosine catabolism, was the first disease to be interpreted as an inborn error of…”
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En bloc TGN recruitment of Aspergillus TRAPPII reveals TRAPP maturation as unlikely to drive RAB1-to-RAB11 transition by Pinar, M, Peñalva, M A

“…TRAnsport Protein Particle (TRAPP) complexes regulate membrane traffic. TRAPPII and TRAPPIII share a core hetero-heptamer, also denoted TRAPPI. In fungi…”
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The upstream region of the IPNS gene determines expression during secondary metabolism in Aspergillus nidulans by Gómez-Pardo, E, Peñalva, M A

“…We have constructed a translational fusion between the isopenicillin-N-synthetase-encoding gene (IPNS) of Aspergillus nidulans and the lacZ gene of Escherichia…”
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The Human Homogentisate 1,2-Dioxygenase (HGO) Gene by Granadino, B., de Bernabé, D.Beltrán-Valero, Fernández-Cañón, J.M., Peñalva, M.A., de Córdoba, S.Rodrı́guez

“…Alkaptonuria (AKU; McKusick No. 203500), a rare hereditary disorder of the phenylalanine catabolism, was the first disease to be interpreted as an inborn error…”
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The optimization of penicillin biosynthesis in fungi by Peñalva, Miguel A, Rowlands, Robert T, Turner, Geoffrey

“…Penicillin production by Penicillium chrysogenum is not only commercially important but arguably the most intensively investigated secondary-metabolic pathway…”
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Cloning of the PYR4 gene encoding orotidine-5'-phosphate decarboxylase in Cephalosporium acremonium by Vian, A, Penalva, M.A

“…We have cloned the Cephalosporium acremonium pyr4 gene by cross-hybridization with the equivalent gene from Neurospora crassa, the closest relative from which…”
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Functional analysis of MCCA and MCCB mutations causing methylcrotonylglycinuria by Desviat, L.R, Pérez-Cerdá, C, Pérez, B, Esparza-Gordillo, J, Rodrı́guez-Pombo, P, Peñalva, M.A, Rodrı́guez de Córdoba, S, Ugarte, M

“…Methylcrotonylglycinuria (MCG; MIM 210200) is an autosomal recessive inherited human disorder caused by the deficiency of 3-methylcrotonyl-CoA carboxylase…”
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Low level expression in Escherichia coli of a fungal gene under the control of strong promoters by Patiño, C, Sánchez, F, Peñalva, M A

“…We have chosen the Isopenicillin N synthetase (IPNS) gene from Cephalosporium acremonium to study its expression in Escherichia coli due to its peculiar DNA…”
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