Search Results - "Peña, Andrea"
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Transcriptomic profiles of post-smolt Atlantic salmon challenged with Piscirickettsia salmonis reveal a strategy to evade the adaptive immune response and modify cell-autonomous immunity
Published in Developmental and comparative immunology (01-04-2018)“…Piscirickettsiosis is the main bacterial disease affecting the Chilean salmon farming industry and is responsible for high economic losses. The development of…”
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Gene expression associated with immune response in Atlantic salmon head-kidney vaccinated with inactivated whole-cell bacterin of Piscirickettsia salmonis and pathogenic isolates
Published in Fish & shellfish immunology (01-10-2019)“…Piscirickettsiosis is the most challenging disease present in the Chilean salmon industry. The aim of this study was to describe the expression of genes…”
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Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: Performance evaluation of the new REGA version 3 and seven other tools
Published in Infection, genetics and evolution (01-10-2013)“…•We compared the new REGA version 3, with other seven subtyping tools.•Reproducibility was 100% with similarity-based tools and statistical-based…”
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Inhibitory effect of concomitantly administered rabies immunoglobulins on the immunogenicity of commercial and candidate human rabies vaccines in hamsters
Published in Scientific reports (21-04-2022)“…The World Health Organization protocol for rabies post-exposure prophylaxis (PEP) recommends extensive wound washing, immediate vaccination, and administration…”
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The reintegration of ex-combatants and post-conflict violence. An analysis of municipal crime levels in Colombia
Published in Conflict management and peace science (01-05-2021)“…Violent crime in Colombia is analyzed following the demobilization of ex-combatants using municipal-level data. The main findings are that an increased…”
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Bacterial microbiota associated with the leaf‐cutting ant Atta cephalotes (Hymenoptera: Myrmicinae): Dynamics during development and potential role in defence
Published in Physiological entomology (01-03-2024)“…The biological complexity of leaf‐cutting ants is determined in part by both positive and negative associations with microorganisms. These ants constantly face…”
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Current vaccination strategy against Piscirickettsia salmonis in Chile based only on the EM-90 genogroup shows incomplete cross-protection for the LF-89 genogroup
Published in Fish & shellfish immunology (01-11-2024)“…Piscirickettsia salmonis, the primary bacterial disease in Chilean salmon farming, necessitates a constant refinement of control strategies. This study…”
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Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology
Published in The Journal of infectious diseases (19-06-2019)“…Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public…”
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Drivers of HIV-1 transmission: The Portuguese case
Published in PloS one (30-09-2019)“…Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their…”
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Immunogenicity and Safety of a Purified Vero Rabies Vaccine—Serum Free, Compared With 2 Licensed Vaccines, in a Simulated Rabies Post-Exposure Regimen in Healthy Adults in France: A Randomized, Controlled, Phase 3 Trial
Published in Clinical infectious diseases (14-06-2024)“…Abstract Background A next-generation Vero cell rabies vaccine (PVRV-NG2) was developed using the same Pitman–Moore strain as in the licensed purified Vero…”
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"Trust Women": Characteristics of and learnings from patients of a Shield Law medication abortion practice in the United States
Published in Perspectives on sexual and reproductive health (30-09-2024)“…The 2022 Massachusetts Shield Law protects telemedicine providers who care for abortion seekers in other states from criminal, civil, and licensure penalties…”
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An integrated map of HIV genome-wide variation from a population perspective
Published in Retrovirology (15-02-2015)“…The HIV pandemic is characterized by extensive genetic variability, which has challenged the development of HIV drugs and vaccines. Although HIV genomes have…”
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Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice
Published in Journal of medicinal chemistry (25-08-2022)“…Spinal cord injuries (SCIs) irreversibly disrupt spinal connectivity, leading to permanent neurological disabilities. Current medical treatments for reducing…”
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Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery
Published in Journal of medicinal chemistry (13-05-2021)“…Bacterial resistance to antibiotics makes previously manageable infections again disabling and lethal, highlighting the need for new antibacterial strategies…”
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Discovery of V‑0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide‑1 Receptor toward Oral Treatment for “Diabesity”
Published in Journal of medicinal chemistry (14-04-2022)“…Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for…”
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Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users
Published in PloS one (09-10-2017)“…Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission…”
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Safety and immunogenicity of three dose levels of an investigational, highly purified Vero cell rabies vaccine: A randomized, controlled, observer-blinded, Phase II study with a simulated post-exposure regimen in healthy adults
Published in Human vaccines & immunotherapeutics (15-12-2023)“…A serum-free, highly purified rabies vaccine produced in Vero cells is under development. The initial formulation, PVRV-NG, was evaluated in five Phase II…”
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Inter‐Laboratory Comparison of qPCR Assays for Piscirickettsia salmonis in Atlantic Salmon ( Salmo salar L.) in 11 Chilean Laboratories
Published in Journal of fish diseases (12-11-2024)“…Real‐time PCR (qPCR) testing is an essential component of early detection surveillance systems for Piscirickettsia salmonis infection in Atlantic salmon farms…”
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Genetic diversity and population structure of Saccharum hybrids
Published in PloS one (15-08-2023)“…Sugarcane breeding programs incorporate foreign material to broaden the genetic base, expanding the gene pool. In South America, the Inter-university Network…”
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Full recombinant flagellin B from Vibrio anguillarum (rFLA) and its recombinant D1 domain (rND1) promote a pro-inflammatory state and improve vaccination against P. salmonis in Atlantic salmon (S. salar)
Published in Developmental and comparative immunology (01-04-2021)“…Flagellin is the major component of the flagellum, and a ligand for Toll-like receptor 5. As reported, recombinant flagellin (rFLA) from Vibrio anguillarum and…”
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