Search Results - "Pazarentzos, E"

Adaptive stress signaling in targeted cancer therapy resistance by Pazarentzos, E, Bivona, T G

“…The identification of specific genetic alterations that drive the initiation and progression of cancer and the development of targeted drugs that act against…”
Get full text

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction by Hwang, M-S, Schwall, C T, Pazarentzos, E, Datler, C, Alder, N N, Grimm, S

“…Massive Ca 2+ influx into mitochondria is critically involved in cell death induction but it is unknown how this activates the organelle for cell destruction…”
Get full text

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF by Mahul-Mellier, A-L, Pazarentzos, E, Datler, C, Iwasawa, R, AbuAli, G, Lin, B, Grimm, S

“…Components of the TNFR1 complex are subject to dynamic ubiquitination that impacts on their effects as signalling factors. We have found that the…”
Get full text

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction by Lemarie, A, Huc, L, Pazarentzos, E, Mahul-Mellier, A-L, Grimm, S

“…The formation of reactive oxygen species (ROS) and the change of the intracellular pH (pH i ) are common phenomena during apoptosis. How they are…”
Get full text

Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation by Pazarentzos, E, Giannikopoulos, P, Hrustanovic, G, St John, J, Olivas, V R, Gubens, M A, Balassanian, R, Weissman, J, Polkinghorn, W, Bivona, T G

“…Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN…”
Get full text

Stefan Grimm, 1963–2014, a tragic loss for the scientific community by Mahul-Mellier, A-L, Huc, L, Lemarié, A, Irshad, S, Hwang, M, Datler, C, Pazarentzos, E

Get full text

Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3CβD1067V kinase domain mutation by Pazarentzos, E, Giannikopoulos, P, Hrustanovic, G, St John, J, Olivas, V R, Gubens, M A, Balassanian, R, Weissman, J, Polkinghorn, W, Bivona, T G

“…Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN…”
Get full text

The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis by AbuAli, G, Chaisaklert, W, Stelloo, E, Pazarentzos, E, Hwang, M-S, Qize, D, Harding, S V, Al-Rubaish, A, Alzahrani, A J, Al-Ali, A, Sanders, T A B, Aboagye, E O, Grimm, S

“…ORCTL3 is a member of a group of genes, the so-called anticancer genes, that cause tumour-specific cell death. We show that this activity is triggered in…”
Get full text

Stefan Grimm, 1963-2014, a tragic loss for the scientific community Obituary by Mahul-Mellier, A-L, Huc, Laurence, Lemarié, A., Irshad, S., Hwang, M., Datler, C., Pazarentzos, E.

Get full text

Oncogenic activation of the PI3-kinase p110 beta isoform via the tumor-derived PIK3C beta super(D1067V) kinase domain mutation by Pazarentzos, E, Giannikopoulos, P, Hrustanovic, G, St John, J, Olivas, V R, Gubens, M A, Balassanian, R, Weissman, J, Polkinghorn, W, Bivona, T G

“…Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN…”
Get full text

Oncogenic activation of the PI3-kinase p110[beta] isoform via the tumor-derived PIK3C[beta]D1067V kinase domain mutation by Pazarentzos, E, Giannikopoulos, P, Hrustanovic, G, St John, J, Olivas, V R, Gubens, M A, Balassanian, R, Weissman, J, Polkinghorn, W, Bivona, T G

“…Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN…”
Get full text

Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived [PIK3Cβ.sup.D1067V] kinase domain mutation by Pazarentzos, E, Giannikopoulos, P, Hrustanovic, G, St. John, J, Olivas, V.R, Gubens, M.A, Balassanian, R, Weissman, J, Polkinghorn, W, Bivona, T.G

“…Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN…”
Get full text

Mitochondrial Ca(2+) influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction by Hwang, M-S, Schwall, C T, Pazarentzos, E, Datler, C, Alder, N N, Grimm, S

“…Massive Ca(2+) influx into mitochondria is critically involved in cell death induction but it is unknown how this activates the organelle for cell destruction…”
Get full text