Search Results - "Payne, Philip R"

Questions for Artificial Intelligence in Health Care by Maddox, Thomas M, Rumsfeld, John S, Payne, Philip R. O

“…Artificial intelligence (Al) is gaining high visibility in the realm of health care innovation. Broadly defined, Al is a field of computer science that aims to…”
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A protocol to evaluate RNA sequencing normalization methods by Abrams, Zachary B, Johnson, Travis S, Huang, Kun, Payne, Philip R O, Coombes, Kevin

“…RNA sequencing technologies have allowed researchers to gain a better understanding of how the transcriptome affects disease. However, sequencing technologies…”
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Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19 by Li, Fuhai, Boon, Adrianus C. M., Michelson, Andrew P., Foraker, Randi E., Zhan, Ming, Payne, Philip R. O.

“…Although vaccines have been evaluated and approved for SARS-CoV-2 infection prevention, there remains a lack of effective treatments to reduce the mortality of…”
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Examining heterogeneity in dementia using data-driven unsupervised clustering of cognitive profiles by Kumar, Sayantan, Oh, Inez Y, Schindler, Suzanne E, Ghoshal, Nupur, Abrams, Zachary, Payne, Philip R. O

“…Dementia is characterized by a decline in memory and thinking that is significant enough to impair function in activities of daily living. Patients seen in…”
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Factors Associated With Variability in the Performance of a Proprietary Sepsis Prediction Model Across 9 Networked Hospitals in the US by Lyons, Patrick G, Hofford, Mackenzie R, Yu, Sean C, Michelson, Andrew P, Payne, Philip R O, Hough, Catherine L, Singh, Karandeep

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Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling by Dong, Zehao, Zhang, Heming, Chen, Yixin, Payne, Philip R. O, Li, Fuhai

“…Synergistic drug combinations provide huge potentials to enhance therapeutic efficacy and to reduce adverse reactions. However, effective and synergistic drug…”
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A Pragmatic Machine Learning Model To Predict Carbapenem Resistance by McGuire, Ryan J, Yu, Sean C, Payne, Philip R O, Lai, Albert M, Vazquez-Guillamet, M Cristina, Kollef, Marin H, Michelson, Andrew P

“…Infection caused by carbapenem-resistant (CR) organisms is a rising problem in the United States. While the risk factors for antibiotic resistance are well…”
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Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2 by Li, Fuhai, Michelson, Andrew P, Foraker, Randi, Zhan, Ming, Payne, Philip R O

“…The Coronavirus Disease 2019 (COVID-19) pandemic has infected over 10 million people globally with a relatively high mortality rate. There are many…”
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Pattern recognition in lymphoid malignancies using CytoGPS and Mercator by Abrams, Zachary B, Tally, Dwayne G, Zhang, Lin, Coombes, Caitlin E, Payne, Philip R O, Abruzzo, Lynne V, Coombes, Kevin R

“…There have been many recent breakthroughs in processing and analyzing large-scale data sets in biomedical informatics. For example, the CytoGPS algorithm has…”
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Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease by Li, Fuhai, Eteleeb, Abdallah M, Buchser, William, Sohn, Christopher, Wang, Guoqiao, Xiong, Chengjie, Payne, Philip R, McDade, Eric, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos

“…Neuroinflammation signaling has been identified as an important hallmark of Alzheimer's disease (AD) in addition to amyloid β plaques (Aβ) and neurofibrillary…”
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PathFinder: a novel graph transformer model to infer multi-cell intra- and inter-cellular signaling pathways and communications by Feng, Jiarui, Song, Haoran, Province, Michael, Li, Guangfu, Payne, Philip R O, Chen, Yixin, Li, Fuhai

“…Recently, large-scale scRNA-seq datasets have been generated to understand the complex signaling mechanisms within the microenvironment of Alzheimer's Disease…”
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Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling by Latchana, Nicholas, del Campo, Sara E. Martin, Grignol, Valerie P., Clark, Jennifer R., Albert, Scott P., Zhang, Jie, Wei, Lai, Aldrink, Jennifer H., Nicol, Kathleen K., Ranalli, Mark A., Peters, Sara B., Gru, Alejandro, Trihka, Prashant, Payne, Philip R. O., Howard, J. Harrison, Carson, William E.

“…Purpose Identification of indeterminate melanocytic skin lesions capable of neoplastic progression is suboptimal and may potentially result in unnecessary…”
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Machine learning for modeling the progression of Alzheimer disease dementia using clinical data: a systematic literature review by Kumar, Sayantan, Oh, Inez, Schindler, Suzanne, Lai, Albert M, Payne, Philip R O, Gupta, Aditi

“…Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of…”
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Cognitive plausibility in voice-based AI health counselors by Kannampallil, Thomas, Smyth, Joshua M., Jones, Steve, Payne, Philip R. O., Ma, Jun

“…Voice-based personal assistants using artificial intelligence (AI) have been widely adopted and used in home-based settings. Their success has created…”
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When past is not a prologue: Adapting informatics practice during a pandemic by Kannampallil, Thomas G, Foraker, Randi E, Lai, Albert M, Woeltje, Keith F, Payne, Philip R O

“…Abstract Data and information technology are key to every aspect of our response to the current coronavirus disease 2019 (COVID-19) pandemic—including the…”
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Chapter 1: Biomedical knowledge integration by Payne, Philip R O

“…The modern biomedical research and healthcare delivery domains have seen an unparalleled increase in the rate of innovation and novel technologies over the…”
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Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes by Regan-Fendt, Kelly E., Xu, Jielin, DiVincenzo, Mallory, Duggan, Megan C., Shakya, Reena, Na, Ryejung, Carson, William E., Payne, Philip R. O., Li, Fuhai

“…Systems biology perspectives are crucial for understanding the pathophysiology of complex diseases, and therefore hold great promise for the discovery of novel…”
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Synergistic Drug Combination Prediction by Integrating Multiomics Data in Deep Learning Models by Zhang, Tianyu, Zhang, Liwei, Payne, Philip R O, Li, Fuhai

“…Intrinsic and acquired drug resistance is a major challenge in cancer therapy. Synergistic drug combinations could help to overcome drug resistance. However,…”
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Translational informatics: enabling high-throughput research paradigms by Payne, Philip R. O, Embi, Peter J, Sen, Chandan K

“…1 Department of Biomedical Informatics, 2 Center for Clinical and Translational Science, and 3 Department of Surgery, The Ohio State University, Columbus; and…”
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Computational challenges and human factors influencing the design and use of clinical research participant eligibility pre-screening tools by Pressler, Taylor R, Yen, Po-Yin, Ding, Jing, Liu, Jianhua, Embi, Peter J, Payne, Philip R O

“…Clinical trials are the primary mechanism for advancing clinical care and evidenced-based practice, yet challenges with the recruitment of participants for…”
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