Search Results - "Payne, Lendon G"

Stabilization of alum-adjuvanted vaccine dry powder formulations: mechanism and application by Maa, Yuh-Fun, Zhao, Lu, Payne, Lendon G, Chen, Dexiang

“…Studies were performed to elucidate the mechanism of alum gel coagulation upon freezing and drying and its relationship to vaccine potency loss and to develop…”
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Plasmid Vectors Encoding Cholera Toxin or the Heat-Labile Enterotoxin from Escherichia coli Are Strong Adjuvants for DNA Vaccines by Arrington, Joshua, Braun, Ralph P, Dong, Lichun, Fuller, Deborah H, Macklin, Michael D, Umlauf, Scott W, Wagner, Sarah J, Wu, Mary S, Payne, Lendon G, Haynes, Joel R

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Characterization of the IFN-gamma T-cell responses to immediate early antigens in humans with genital herpes by Braun, Ralph P, Payne, Lendon G, Dong, Lichun

“…The IFN-gamma ELISPOT assay has been used to examine the T-cell repertoire for many disease states in humans but, as yet, not genital herpes. Using overlapping…”
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Targeting epidermal Langerhans cells by epidermal powder immunization by Chen, Dexiang, Payne, Lendon G

“…Immune reactions to foreign or self-antigens lead to protective immunity and, sometimes, immune disorders such as allergies and autoimmune diseases. Antigen…”
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Spray-coating for biopharmaceutical powder formulations: beyond the conventional scale and its application by Maa, Yuh-Fun, Ameri, Mahmoud, Rigney, Robert, Payne, Lendon G, Chen, Dexiang

“…Fluid-bed spray-coating process is widely used to prepare non-protein pharmaceutical solid dosage forms using macro-size seed particles (200-1000 microm) at…”
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Multi-antigenic DNA immunization using herpes simplex virus type 2 genomic fragments by Braun, Ralph P., Dong, Lichun, Jerome, Sarah, Herber, Renee, Roberts, Lee K., Payne, Lendon G.

“…A novel DNA vaccine was generated using genomic fragments of a pathogen as the source of both the antigen coding and regulatory regions. The constructs, termed…”
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Influenza vaccine powder formulation development: spray-freeze-drying and stability evaluation by Maa, Yuh-Fun, Ameri, Mahmoud, Shu, Cassandra, Payne, Lendon G, Chen, Dexiang

“…The purpose of this study was to develop a spray-freeze-drying (SFD) process for preparing an influenza vaccine dry powder formulation suitable for epidermal…”
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Polymeric carriers for oral uptake of microparticulates by Andrianov, Alexander K, Payne, Lendon G

“…Delivery of vaccine antigens by the oral route is plagued with challenges. Much of the research has focused on the development of microparticles as antigen…”
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Potent protective cellular immune responses generated by a DNA vaccine encoding HSV-2 ICP27 and the E. coli heat labile enterotoxin by Haynes, Joel R., Arrington, Joshua, Dong, Lichun, Braun, Ralph P., Payne, Lendon G.

“…A mouse model was employed to evaluate protective cellular immune responses induced by an immediate early antigen of HSV-2. Particle-mediated DNA vaccination…”
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Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice by Chen, Dexiang, Endres, Ryan L, Erickson, Cherie A, Weis, Kathleen F, McGregor, Martha W, Kawaoka, Yoshihiro, Payne, Lendon G

“…Human vaccines are typically injected into muscle despite its inconsequential function in the induction of subsequent immune responses. In contrast, skin, a…”
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Protein release from polyphosphazene matrices by Andrianov, Alexander K, Payne, Lendon G

“…Polyphosphazenes have been exploited as carriers for protein delivery due to versatility of molecular structures and sophisticated spectrum of chemical and…”
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Epidermal Powder Immunization Induces both Cytotoxic T-Lymphocyte and Antibody Responses to Protein Antigens of Influenza and Hepatitis B Viruses by Chen, D, Weis, K F, Chu, Q, Erickson, C, Endres, R, Lively, C R, Osorio, J, Payne, L G

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Epidermal powder immunization of mice and monkeys with an influenza vaccine by Chen, Dexiang, Endres, Ryan, Maa, Yuh-Fun, Kensil, Charlotte R., Whitaker-Dowling, Patricia, Trichel, Anita, Youngner, Julius S., Payne, Lendon G.

“…Epidermal powder immunization (EPI) with an influenza vaccine and an adjuvant such as QS-21, LTR72, or cholera toxin elicited augmented serum and mucosal…”
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Serum and Mucosal Immune Responses to an Inactivated Influenza Virus Vaccine Induced by Epidermal Powder Immunization by Chen, D, Periwal, S B, Larrivee, K, Zuleger, C, Erickson, C A, Endres, R L, Payne, L G

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Peptide induces CD4 +CD25 + and IL-10 + T cells and protection in airway allergy models by Zuleger, Cindy L., Gao, Xiaoyan, Burger, Melissa S., Chu, Qili, Payne, Lendon G., Chen, Dexiang

“…The purpose of this study was to evaluate whether a single peptide containing a major T cell epitope might induce peripheral tolerance in a complex allergen…”
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Adjuvantation of epidermal powder immunization by Chen, Dexiang, Erickson, Cherie A, Endres, Ryan L, Periwal, Sangeeta B, Chu, Qili, Shu, Cassandra, Maa, Yuh-Fun, Payne, Lendon G

“…The skin is an immunologically active site and an attractive vaccination route. All current vaccines, however, are administered either orally, intramuscularly,…”
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An antigen-independent but not antigen-specific TH1 response provides protection in the murine airway inflammation model by Burger, Melissa S., Zuleger, Cindy L., Chu, Qili, Gao, Xiaoyan, Payne, Lendon G., Chen, Dexiang

“…Atopic disorders are associated with an imbalanced TH cell response biased toward a strong TH2 type, resulting in excessive production of IgE antibodies,…”
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Epidermal powder immunization: cellular and molecular mechanisms for enhancing vaccine immunogenicity by Chen, Dexiang, Burger, Melissa, Chu, Qili, Endres, Ryan, Zuleger, Cindy, Dean, Hansi, Payne, Lendon G

“…Epidermal powder immunization (EPI) of mice with an influenza vaccine elicited consistently a higher hemagglutination inhibition (HI) antibody titers than…”
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Optimization of an alum-adsorbed vaccine powder formulation for epidermal powder immunization by MAA, Yuh-Fun, SHU, Cassandra, AMERI, Mahmoud, ZULEGER, Cindy, CHE, Jenny, OSORIO, Jorge E, PAYNE, Lendon G, DEXIANG CHEN

“…To develop stable and effective aluminum salt (alum)-adsorbed vaccine powder formulations for epidermal powder immunization (EPI) via a spray freeze-drying…”
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Poly[di(carboxylatophenoxy)phosphazene] (PCPP) is a potent immunoadjuvant for an influenza vaccine by Payne, Lendon G, Jenkins, Sharon A, Woods, Angela L, Grund, Eric M, Geribo, Walter E, Loebelenz, Jean R, Andrianov, Alexander K, Roberts, Bryan E

“…The adjuvant activity of poly[di(carboxylatophenoxy)phosphazene] (PCPP) on the immunogenicity of formalin-inactivated influenza virions and commercial…”
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