Search Results - "Payne, John A."

Cation-chloride cotransporters in neuronal development, plasticity and disease by Kaila, Kai, Price, Theodore J., Payne, John A., Puskarjov, Martin, Voipio, Juha

“…Key Points The regulation of intraneuronal Cl − by cation-chloride cotransporters (CCCs) has a key role in determining the reversal potential ( E GABA ) and…”
Get full text

Cation–chloride co-transporters in neuronal communication, development and trauma by Payne, John A, Rivera, Claudio, Voipio, Juha, Kaila, Kai

“…Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the…”
Get full text

Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2 by Lee, Henry H.C., Walker, Joshua A., Williams, Jeffery R., Goodier, Richard J., Payne, John A., Moss, Stephen J.

“…The potassium chloride cotransporter KCC2 plays a major role in the maintenance of transmembrane chloride potential in mature neurons; thus KCC2 activity is…”
Get full text

Comment on "Local impermeant anions establish the neuronal chloride concentration" by Voipio, Juha, Boron, Walter F, Jones, Stephen W, Hopfer, Ulrich, Payne, John A, Kaila, Kai

“…Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, "local impermeant anions establish the neuronal chloride…”
Get full text

Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2 by Rivera, Claudio, Voipio, Juha, Thomas-Crusells, Judith, Li, Hong, Emri, Zsuzsa, Sipila, Sampsa, Payne, John A, Minichiello, Liliana, Saarma, Mart, Kaila, Kai

“…GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained…”
Get full text

The K + /Cl − co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation by Kaila, Kai, Rivera, Claudio, Voipio, Juha, Payne, John A, Ruusuvuori, Eva, Lahtinen, Hannele, Lamsa, Karri, Pirvola, Ulla, Saarma, Mart

“…GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts its fast hyperpolarizing effect through activation of anion…”
Get full text

K+-Cl- cotransporter-2 KCC2 in chicken cardiomyocytes by Antrobus, Shane P, Lytle, Christian, Payne, John A

“…Using antibodies prepared against a unique region (exon 22-24) of rat K(+)-Cl(-) cotransporter-2 (KCC2), we confirmed that the ~140-kDa KCC2 protein is…”
Get more information

Inflammation alters cation chloride cotransporter expression in sensory neurons by Morales-Aza, Begonia M., Chillingworth, Naomi L., Payne, John A., Donaldson, Lucy F.

“…Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of…”
Get full text

Cation transport by the neuronal K(+)-Cl(-) cotransporter KCC2: thermodynamics and kinetics of alternate transport modes by Williams, Jeffery R, Payne, John A

“…Both Cs(+) and NH(4)(+) alter neuronal Cl(-) homeostasis, yet the mechanisms have not been clearly elucidated. We hypothesized that these two cations altered…”
Get more information

Localization and Developmental Expression Patterns of the Neuronal K-Cl Cotransporter (KCC2) in the Rat Retina by Vu, Tania Q, Payne, John A, Copenhagen, David R

“…The processing of signals by integrative neurons in the retina and CNS relies strongly on inhibitory synaptic inputs, principally from GABAergic and…”
Get full text

Molecular operation of the cation chloride cotransporters: ion binding and inhibitor interaction by Payne, John A

“…The cation chloride cotransporters (CCCs) represent an important family of transporters that plays key roles in vectorial electrolyte movement across epithelia…”
Get full text

Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy by Karlócai, Mária R., Wittner, Lucia, Tóth, Kinga, Maglóczky, Zsófia, Katarova, Zoja, Rásonyi, György, Erőss, Loránd, Czirják, Sándor, Halász, Péter, Szabó, Gábor, Payne, John A., Kaila, Kai, Freund, Tamás F.

“…Synaptic reorganization in the epileptic hippocampus involves altered excitatory and inhibitory transmission besides the rearrangement of dendritic spines,…”
Get full text

Effects of essential amino acid deficiency: down‐regulation of KCC2 and the GABAA receptor; disinhibition in the anterior piriform cortex by Sharp, James W., Ross‐Inta, Catherine M., Baccelli, Irène, Payne, John A., Rudell, John B., Gietzen, Dorothy W.

“…The anterior piriform cortex (APC) is activated by, and is the brain area most sensitive to, essential (indispensable) amino acid (IAA) deficiency. The APC is…”
Get full text

Evidence That Different Cation Chloride Cotransporters in Retinal Neurons Allow Opposite Responses to GABA by Vardi, Noga, Zhang, Ling-Li, Payne, John A, Sterling, Peter

“…GABA gating an anion channel primarily permeable to chloride can hyperpolarize or depolarize, depending on whether the chloride equilibrium potential (E(Cl))…”
Get full text

The Neuron-specific K-Cl Cotransporter, KCC2 by Williams, Jeffery R., Sharp, James W., Kumari, Vijaya G., Wilson, Martin, Payne, John A.

“…The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl − extrusion pathway important in postsynaptic inhibition mediated…”
Get full text

Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney by J A Payne, B Forbush, 3rd

“…We have used cDNA probes derived from the secretory form of the Na-K-Cl cotransporter to screen both cortical and medullary rabbit kidney cDNA libraries. A…”
Get full text

Molecular Cloning and Functional Expression of the Bumetanide-Sensitive Na-K-Cl Cotransporter by Xu, Jian-Chao, Lytle, Christian, Zhu, Tracey T., Payne, John A., Benz, Edward, Forbush, Bliss

“…By mediating the coupled movement of Na, K, and Cl ions across the plasma membrane of most animal cells, the bumetanide-sensitive Na-K-Cl cotransporter (NKCC)…”
Get full text

Primary Structure, Functional Expression, and Chromosomal Localization of the Bumetanide-sensitive Na-K-Cl Cotransporter in Human Colon by Payne, J A, Xu, J C, Haas, M, Lytle, C Y, Ward, D, Forbush, 3rd, B

“…By moving chloride into epithelial cells, the Na-K-Cl cotransporter aids transcellular movement of chloride across both secretory and absorptive epithelia…”
Get full text

Expression of the basolateral Na–K–Cl cotransporter during mouse nephrogenesis and embryonic development by Vanden Heuvel, Gregory B., Payne, John A., Igarashi, Peter, Forbush, Bliss

“…We examined the expression of Slc12a2 (NKCC1) transcripts in the developing mouse by Northern blot analysis and in situ hybridization (ISH) using riboprobes…”
Get full text

Protection of ischemic myocardium in diabetics by inhibition of electroneutral Na+-K+-2Cl- cotransporter by Ramasamy, R, Payne, J A, Whang, J, Bergmann, S R, Schaefer, S

“…Diabetes increases both the incidence of cardiovascular disease and complications of myocardial infarction and heart failure. Studies using diabetic animals…”
Get more information