Search Results - "Payen, L."

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway by Payen, Valéry L., Porporato, Paolo E., Baselet, Bjorn, Sonveaux, Pierre

“…Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are characterized by a high metabolic plasticity resulting from…”
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Monocarboxylate transporters in cancer by Payen, Valéry L., Mina, Erica, Van Hée, Vincent F., Porporato, Paolo E., Sonveaux, Pierre

“…Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer…”
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Monocarboxylate transporters in the brain and in cancer by Pérez-Escuredo, Jhudit, Van Hée, Vincent F., Sboarina, Martina, Falces, Jorge, Payen, Valéry L., Pellerin, Luc, Sonveaux, Pierre

“…Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1–4 facilitate the passive transport of monocarboxylates such as lactate,…”
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A Mitochondrial Switch Promotes Tumor Metastasis by Porporato, Paolo E., Payen, Valéry L., Pérez-Escuredo, Jhudit, De Saedeleer, Christophe J., Danhier, Pierre, Copetti, Tamara, Dhup, Suveera, Tardy, Morgane, Vazeille, Thibaut, Bouzin, Caroline, Feron, Olivier, Michiels, Carine, Gallez, Bernard, Sonveaux, Pierre

“…Metastatic progression of cancer is associated with poor outcome, and here we examine metabolic changes underlying this process. Although aerobic glycolysis is…”
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Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter by Payen, Valéry L, Hsu, Myriam Y, Rädecke, Kristin S, Wyart, Elisabeth, Vazeille, Thibaut, Bouzin, Caroline, Porporato, Paolo E, Sonveaux, Pierre

“…Extracellular acidosis resulting from intense metabolic activities in tumors promotes cancer cell migration, invasion, and metastasis. Although host cells die…”
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Cancer metabolism in space and time: Beyond the Warburg effect by Danhier, Pierre, Bański, Piotr, Payen, Valéry L, Grasso, Debora, Ippolito, Luigi, Sonveaux, Pierre, Porporato, Paolo E

“…Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several…”
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PLGA: From a classic drug carrier to a novel therapeutic activity contributor by Chereddy, Kiran Kumar, Payen, Valéry L., Préat, Véronique

“…Poly(lactic-co-glycolic acid) (PLGA) is well known for its biocompatibility and minimal toxicity. It is one of the most promising biodegradable polymeric drug…”
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Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism by Porporato, Paolo E., Payen, Valéry L., Baselet, Bjorn, Sonveaux, Pierre

“…Metabolic alterations are a hallmark of cancer controlling tumor progression and metastasis. Among the various metabolic phenotypes encountered in tumors, this…”
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Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity by Payen, Valéry L., Lavergne, Arnaud, Alevra Sarika, Niki, Colonval, Megan, Karim, Latifa, Deckers, Manon, Najimi, Mustapha, Coppieters, Wouter, Charloteaux, Benoît, Sokal, Etienne M., El Taghdouini, Adil

“…The multiple vital functions of the human liver are performed by highly specialised parenchymal and non-parenchymal cells organised in complex collaborative…”
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Pro- and antitumor effects of mitochondrial reactive oxygen species by Payen, Valéry L., Zampieri, Luca X., Porporato, Paolo E., Sonveaux, Pierre

“…In cancer, mitochondrial functions are commonly altered. Directly involved in metabolic reprogramming, mitochondrial plasticity confers to cancer cells a high…”
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Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice by Porporato, Paolo E., Payen, Valéry L., De Saedeleer, Christophe J., Préat, Véronique, Thissen, Jean-Paul, Feron, Olivier, Sonveaux, Pierre

“…Wounds notoriously accumulate lactate as a consequence of both anaerobic and aerobic glycolysis following microcirculation disruption, immune activation, and…”
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Common responses of tumors and wounds to hypoxia by Payen, Valéry L, Brisson, Lucie, Dewhirst, Mark W, Sonveaux, Pierre

“…Hypoxia is a characteristic of tumors and wounds. Hypoxic cells develop 2 common strategies to face hypoxia: the glycolytic switch and the angiogenic switch…”
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Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation by De Preter, Géraldine, Neveu, Marie-Aline, Danhier, Pierre, Brisson, Lucie, Payen, Valéry L, Porporato, Paolo E, Jordan, Bénédicte F, Sonveaux, Pierre, Gallez, Bernard

“…Glucose fermentation through glycolysis even in the presence of oxygen (Warburg effect) is a common feature of cancer cells increasingly considered as an…”
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Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes by Milosevic, Tamara V, Payen, Valéry L, Sonveaux, Pierre, Muccioli, Giulio G, Tulkens, Paul M, Van Bambeke, Françoise

“…Linezolid, the first clinically available oxazolidinone antibiotic, causes potentially severe toxicities (myelosuppression, lactic acidosis, and neuropathies)…”
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Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation by Gratpain, Viridiane, Loriot, Axelle, Bottemanne, Pauline, d’Auria, Ludovic, Terrasi, Romano, Payen, Valéry L., van Pesch, Vincent, Muccioli, Giulio G., des Rieux, Anne

“…Neuro-inflammation occurs in numerous disorders such as multiple sclerosis, Alzheimer's disease and Parkinson's disease. However, anti-inflammatory drugs for…”
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(+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice by Payen, Valéry L, Porporato, Paolo E, Danhier, Pierre, Vazeille, Thibaut, Blackman, Marine C N M, May, Bronislav H, Niebes, Paul, Sonveaux, Pierre

“…Metastasis is of dismal prognosis for cancer patients, but recent evidence in mouse models of cancer shows that metastasis prevention is a reachable clinical…”
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MitoQ Prevents Human Breast Cancer Recurrence and Lung Metastasis in Mice by Capeloa, Tania, Krzystyniak, Joanna, Rodriguez, Amanda Canas, Payen, Valéry L, Zampieri, Luca X, Pranzini, Erica, Derouane, Françoise, Vazeille, Thibaut, Bouzin, Caroline, Duhoux, François P, Murphy, Michael P, Porporato, Paolo E, Sonveaux, Pierre

“…In oncology, the occurrence of distant metastases often marks the transition from curative to palliative care. Such outcome is highly predictable for breast…”
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Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines by Milosevic, Tamara V., Vertenoeil, Gaëlle, Payen, Valéry L., Sonveaux, Pierre, Tulkens, Paul M., Constantinescu, Stefan N., Van Bambeke, Françoise

“…•Oxazolidinones (e.g. linezolid, tedizolid) reversibly impair mitochondrial protein synthesis and metabolic functions in various cell types, but the link with…”
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Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes by Contino, Sabrina, Suelves, Nuria, Vrancx, Céline, Vadukul, Devkee M, Payen, Valery L, Stanga, Serena, Bertrand, Luc, Kienlen-Campard, Pascal

“…Presenilin 1 (PS1) and Presenilin 2 (PS2) are predominantly known as the catalytic subunits of the γ-secretase complex that generates the amyloid-β (Aβ)…”
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Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence by Gitenay, D, Wiel, C, Lallet-Daher, H, Vindrieux, D, Aubert, S, Payen, L, Simonnet, H, Bernard, D

“…Oncogenic stress-induced senescence (OIS) prevents the ability of oncogenic signals to induce tumorigenesis. It is now largely admitted that the mitogenic…”
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