Search Results - "Payan, Donald G."

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer by HOLLAND, Sacha J, PAN, Alison, JING ZHANG, PINGYU DING, APATIRA, Ayodele, CHUA, Joanne, BRANDT, Ralf, PINE, Polly, GOFF, Dane, SINGH, Rajinder, PAYAN, Donald G, HITOSHI, Yasumichi, FRANCI, Christian, YUANMING HU, CHANG, Betty, WEIQUN LI, DUAN, Matt, TORNEROS, Allan, JIAXIN YU, HECKRODT, Thilo J

“…Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient…”
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Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors by Singh, Rajinder, Masuda, Esteban S, Payan, Donald G

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R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation by Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Wang, Su, Sylvain, Catherine, Baluom, Muhammad, Qu, Kunbin, Herlaar, Ellen, Lau, Angela, Young, Chi, Wong, Brian R, Lovell, Scott, Sun, Thomas, Park, Gary, Argade, Ankush, Jurcevic, Stipo, Pine, Polly, Singh, Rajinder, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S

“…Recent compelling evidence has lead to renewed interest in the role of antibodies and immune complexes in the pathogenesis of several autoimmune disorders,…”
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Developing structure–activity relationships from an HTS hit for inhibition of the Cks1–Skp2 protein–protein interaction by Singh, Rajinder, Sran, Arvinder, Carroll, David C., Huang, Jianing, Tsvetkov, Lyuben, Zhou, Xiulan, Sheung, Julie, McLaughlin, John, Issakani, Sarkiz D., Payan, Donald G., Shaw, Simon J.

“…[Display omitted] Structure–activity relationships have been developed around 5-bromo-8-toluylsulfonamidoquinoline 1 a hit compound in an assay for the…”
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AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes by Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L, Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J, McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J, Xu, Xiang, Issakani, Sarkiz D, Carroll, David C, Goff, Dane A, Shaw, Simon J, Singh, Rajinder, Boros, Laszlo G, Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G, Kinsella, Todd M, Hitoshi, Yasumichi

“…Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein…”
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JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice by Chang, Betty Y, Zhao, Feifei, He, Xiaodong, Ren, Hong, Braselmann, Sylvia, Taylor, Vanessa, Wicks, Joan, Payan, Donald G, Grossbard, Elliott B, Pine, Polly R, Bullard, Daniel C

“…JAK3, a member of the Janus kinase family, is predominantly expressed in hemopoietic cells and binds specifically to the common gamma chain of a subfamily of…”
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Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth by Jenkins, Yonchu, Markovtsov, Vadim, Lang, Wayne, Sharma, Poonam, Pearsall, Denise, Warner, Justin, Franci, Christian, Huang, Betty, Huang, Jianing, Yam, George C, Vistan, Joseph P, Pali, Erlina, Vialard, Jorge, Janicot, Michel, Lorens, James B, Payan, Donald G, Hitoshi, Yasumichi

“…Early cellular events associated with tumorigenesis often include loss of cell cycle checkpoints or alteration in growth signaling pathways. Identification of…”
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The current status and the future of JAK2 inhibitors for the treatment of myeloproliferative diseases by Hitoshi, Yasumichi, Lin, Nan, Payan, Donald G., Markovtsov, Vadim

“…Janus kinases (JAKs) are critical components of cytokine signaling pathways which regulate immunity, inflammation, hematopoiesis, growth, and development. The…”
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Multiple roles for the receptor tyrosine kinase axl in tumor formation by HOLLAND, Sacha J, POWELL, Mark J, WONG, Stephen, LASAGA, Joe, SHEN, Mary R, SIMON YU, WEIDUAN XU, HITOSHI, Yasumichi, BOGENBERGER, Jakob, NÖR, Jacques E, PAYAN, Donald G, LORENS, James B, FRANCI, Christian, CHAN, Emily W, FRIERA, Annabelle M, ATCHISON, Robert E, MCLAUGHLIN, John, SWIFT, Susan E, PALI, Erlina S, YAM, George

“…A focus of contemporary cancer therapeutic development is the targeting of both the transformed cell and the supporting cellular microenvironment. Cell…”
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Substrate Modification with Lysine 63-linked Ubiquitin Chains through the UBC13-UEV1A Ubiquitin-conjugating Enzyme by Petroski, Matthew D., Zhou, Xiulan, Dong, GuoQiang, Daniel-Issakani, Sarkiz, Payan, Donald G., Huang, Jianing

“…Protein modification with lysine 63-linked ubiquitin chains has been implicated in the non-proteolytic regulation of signaling pathways. To understand the…”
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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm by Shide, Kotaro, Kameda, Takuro, Markovtsov, Vadim, Shimoda, Haruko K., Tonkin, Elizabeth, Fang, Shuling, Liu, Chian, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Low, Caroline, Reitsma, Andrea, Siu, Stacey, Pine, Polly, Park, Gary, Torneros, Allan, Duan, Matt, Singh, Rajinder, Payan, Donald G., Matsunaga, Takuya, Hitoshi, Yasumichi, Shimoda, Kazuya

“…The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN…”
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Noninvasive imaging of in vivo MuRF1 expression during muscle atrophy by Li, Wei, Claypool, Mark D, Friera, Annabelle M, McLaughlin, John, Baltgalvis, Kristen A, Smith, Ira J, Kinoshita, Taisei, White, Kathy, Lang, Wayne, Godinez, Guillermo, Payan, Donald G, Kinsella, Todd M

“…Numerous human diseases can lead to atrophy of skeletal muscle, and loss of this tissue has been correlated with increased mortality and morbidity rates…”
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Activation of the PKB/AKT Pathway by ICAM-2 by Perez, Omar D, Kinoshita, Shigemi, Hitoshi, Yasumichi, Payan, Donald G, Kitamura, Toshio, Nolan, Garry P, Lorens, James B

“…We identified intracellular adhesion molecule-2 (ICAM-2) in a genetic screen as an activator of the PI3K/AKT pathway leading to inhibition of apoptosis. ICAM-2…”
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Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators by Shaw, Simon J., Goff, Dane A., Boralsky, Luke A., Singh, Rajinder, Sweeny, David J., Park, Gary, Sun, Tian-Qiang, Jenkins, Yonchu, Markovtsov, Vadim, Issakani, Sarkiz D., Payan, Donald G., Hitoshi, Yasumichi

“…A set of focused analogues have been generated around a lead indirect adenosine monophosphate-activated kinase (AMPK) activator to improve the rat clearance of…”
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The Poxvirus p28 Virulence Factor Is an E3 Ubiquitin Ligase by Huang, Jianing, Huang, Qi, Zhou, Xiulan, Shen, Mary M., Yen, Ann, Yu, Simon X., Dong, GuoQiang, Qu, Kunbin, Huang, Peiyong, Anderson, Emily M., Daniel-Issakani, Sarkiz, Buller, R. Mark L., Payan, Donald G., Lu, H. Henry

“…A majority of the orthopoxviruses, including the variola virus that causes the dreaded smallpox disease, encode a highly conserved 28-kDa protein with a…”
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Bicyclic pyrimidine compounds as potent IRAK4 inhibitors by Chen, Yan, Tso, Kin, Heckrodt, Thilo J., Li, Hui, Yen, Rose, Lin, Nan, Singh, Rajinder, Taylor, Vanessa, Masuda, Esteban S., Park, Gary, Payan, Donald G.

“…[Display omitted] Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in transduction of IL-1R/TLR signaling which is responsible for…”
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Discovery of 5‑Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors by Chen, Yan, Singh, Rajinder, Lin, Nan, Taylor, Vanessa, Masuda, Esteban S, Payan, Donald G

“…IRAK4 kinase plays a key role in TLR/IL-1R signaling pathways that regulate innate immune responses, and if uncontrolled, it is responsible for various…”
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Retrovirally Delivered Random Cyclic Peptide Libraries Yield Inhibitors of Interleukin-4 Signaling in Human B Cells by Kinsella, Todd M., Ohashi, Cara T., Harder, Amy Grace, Yam, George C., Li, Weiqun, Peelle, Beau, Pali, Erlina S., Bennett, Mark K., Molineaux, Susan M., Anderson, D.A., Masuda, Esteban S., Payan, Donald G.

“…Inteins are polypeptide sequences found in a small set of primarily bacterial proteins that promote the splicing of flanking pre-protein sequences to generate…”
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Structure activity relationships leading to the identification of the indirect activator of AMPK, R419 by Shaw, Simon J., Goff, Dane A., Carroll, David C., Singh, Rajinder, Sweeny, David J., Park, Gary, Jenkins, Yonchu, Markovtsov, Vadim, Sun, Tian-Qiang, Issakani, Sarkiz D., Hitoshi, Yasumichi, Payan, Donald G.

“…[Display omitted] Using an in-cell AMPK activation assay, we have developed structure–activity relationships around a hit pyridine dicarboxamide 5 that…”
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R-253 Disrupts Microtubule Networks in Multiple Tumor Cell Lines by GURURAJA, Tarikere L, GOFF, Dane, HITOSHI, Yasumichi, COOPER, R. D. G, PAYAN, Donald G, KINOSHITA, Taisei, GOLDSTEIN, Eileen, YUNG, Stephanie, MCLAUGHLIN, John, PALI, Erlina, JIANING HUANG, SINGH, Rajinder, DANIEL-ISSAKANI, Sarkiz

“…Purpose: The design and development of synthetic small molecules to disrupt microtubule dynamics is an attractive therapeutic strategy for anticancer drug…”
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