Search Results - "PayÁ, Miguel"

Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease by Berthier, Arnaud, Payá, Miguel, García-Cabrero, Ana M., Ballester, Maria Inmaculada, Heredia, Miguel, Serratosa, José M., Sánchez, Marina P., Sanz, Pascual

“…Lafora disease (LD, OMIM 254780) is a rare fatal neurodegenerative disorder that usually occurs during childhood with generalized tonic-clonic seizures,…”
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NF-κB and STAT3 Inhibition as a Therapeutic Strategy in Psoriasis: In Vitro and In Vivo Effects of BTH by Andrés, Rosa M., Montesinos, M. Carmen, Navalón, Pedro, Payá, Miguel, Terencio, M. Carmen

“…Benzo[b]thiophen-2-yl-3-bromo-5-hydroxy-5H-furan-2-one (BTH) is a simple and interesting synthetic derivative of petrosaspongiolide M, a natural compound…”
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Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages by Arasa, Jorge, Terencio, María Carmen, Andrés, Rosa María, Marín-Castejón, Asunción, Valcuende-Cavero, Francisca, Payá, Miguel, Montesinos, María Carmen

“…Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E…”
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Adenosine A2A and A2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis by Andrés, Rosa M., Terencio, María Carmen, Arasa, Jorge, Payá, Miguel, Valcuende-Cavero, Francisca, Navalón, Pedro, Montesinos, María Carmen

“…Adenosine is a potent regulator of inflammation and immunity, but the role of adenosine receptors in keratinocytes remains controversial. We determined that in…”
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Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression by Guerrero, María Dolores, Aquino, Maurizio, Bruno, Ines, Riccio, Raffaele, Terencio, María Carmen, Payá, Miguel

“…In a previous study, we reported a new γ-hydroxybutenolide derivative, 4-benzo[ b]thiophen-2-yl-3-bromo-5-hydroxy-5 H-furan-2-one (BTH), as inhibitor of…”
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Perthamides C–F, potent human antipsoriatic cyclopeptides by Festa, Carmen, De Marino, Simona, Sepe, Valentina, D’Auria, Maria Valeria, Bifulco, Giuseppe, Andrés, Rosa, Terencio, Maria Carmen, Payá, Miguel, Debitus, Cécile, Zampella, Angela

“…Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei. The new structures, featuring an…”
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Avarol inhibits TNF-α generation and NF-κB activation in human cells and in animal models by Amigó, Maria, Payá, Miguel, Braza-Boïls, Aitana, De Rosa, Salvatore, Terencio, Maria Carmen

“…Avarol is a marine sesquiterpenoid hydroquinone with interesting pharmacological properties including anti-inflammatory and antipsoriatic effects. In the…”
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The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production by Rojas, Javier, Payá, Miguel, Dominguez, José N, Luisa Ferrándiz, M

“…Dimethoxy- and trimethoxychalcone derivatives, with various patterns of fluorination, were synthesized and evaluated for their influence on nitric oxide…”
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Potential antipsoriatic effect of chondroitin sulfate through inhibition of NF-κB and STAT3 in human keratinocytes by Andrés, Rosa M., Payá, Miguel, Montesinos, M. Carmen, Ubeda, Amalia, Navalón, Pedro, Herrero, Marta, Vergés, Josep, Terencio, M. Carmen

“…Chondroitin sulfate (CS) is a natural glycosaminoglycan, formed by the 1–3 linkage of d-glucuronic acid to N-acetylgalactosamine, present in the extracellular…”
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Anthrax lethal toxin down-regulates type-IIA secreted phospholipase A2 expression through MAPK/NF-κB inactivation by RAYMOND, Benoit, RAVAUX, Lucas, TOUQUI, Lhousseine, MEMET, Sylvie, YONGZHENG WU, STURNY-LECLERE, Aude, LEDUC, Dominique, DENOYELLE, Chantal, GOOSSENS, Pierre L, PAYA, Miguel, RAYMONDJEAN, Michel

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Coscinolactams A and B : new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties by DE MARINO, Simona, FESTA, Carmen, D'AURIA, Maria Valeria, BOURGUET-KONDRACKI, Marie-Lise, PETEK, Sylvain, DEBITUS, Cecile, ANDRES, Rosa Maria, TERENCIO, Maria Carmen, PAYA, Miguel, ZAMPELLA, Angela

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Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase by Rojas, Javier, Domı́nguez, José N, Charris, Jaime E, Lobo, Gricela, Payá, Miguel, Ferrándiz, M.Luisa

“…A series of nine dimethylamino-chalcone derivatives (1,3-diaryl-propenones) was synthesized and screened as potential inhibitors of NO and PGE 2 production in…”
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Identification of avarol derivatives as potential antipsoriatic drugs using an in vitro model for keratinocyte growth and differentiation by Amigó, María, Schalkwijk, Joost, Olthuis, Diana, De Rosa, Salvatore, Payá, Miguel, Terencio, María Carmen, Lamme, Evert

“…Avarol, a marine sesquiterpenoid hydroquinone, and 14 avarol derivatives have shown interesting anti-inflammatory properties in previous studies. In this…”
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Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M by Busserolles, Jérôme, Payá, Miguel, D’Auria, Maria Valeria, Gomez-Paloma, Luigi, Alcaraz, Maria José

“…Proinflammatory mediators, namely eicosanoids, reactive oxygen and nitrogen species and cytokines, are clearly involved in the pathogenesis of intestinal bowel…”
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Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes by Lucas, Rut, Giannini, Clelia, D'auria, Maria Valeria, Payá, Miguel

“…The marine metabolite bolinaquinone is a novel inhibitor of secretory phospholipase A(2) (sPLA(2)), with a potency on the human synovial enzyme (group II)…”
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Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates by Amigó, María, Terencio, María C., Payá, Miguel, Iodice, Carmine, Rosa, Salvatore De

“…Semisynthesis of 13 new thio avarol derivatives ( 4– 16) and in vitro evaluation on the photodamage response induced by UVB irradiation are described. Their…”
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Potential Antipsoriatic Avarol Derivatives as Antioxidants and Inhibitors of PGE2 Generation and Proliferation in the HaCaT Cell Line by Amigó, Maria, Terencio, Maria Carmen, Mitova, Maya, Iodice, Carmine, Payá, Miguel, De Rosa, Salvatore

“…The synthesis and structure−activity relationships for a series of 14 new avarol derivatives as antioxidants and inhibitors of cell proliferation and PGE2…”
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Cacospongionolide B suppresses the expression of inflammatory enzymes and tumour necrosis factor‐α by inhibiting nuclear factor‐κB activation by Posadas, Inmaculada, De Rosa, Salvatore, Carmen Terencio, M, Payá, Miguel, José Alcaraz, M

“…The marine product cacospongionolide B, a sesterterpene isolated from the Mediterranean sponge Fasciospongia cavernosa, is an inhibitor of secretory…”
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Inhibition of the NF-κB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M by Posadas, Inmaculada, Terencio, Maria Carmen, Randazzo, Antonio, Gomez-Paloma, Luigi, Payá, Miguel, Alcaraz, Maria José

“…Petrosaspongiolide M (PT) is a potent secretory phospholipase A 2 inhibitor and anti-inflammatory agent. This marine metabolite reduced the production of…”
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Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2 by Pastor, Pablo García, De Rosa, Salvatore, De Giulio, Alfonso, Payá, Miguel, Alcaraz, M José

“…Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase…”
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