Search Results - "Paxton, Raymond J"

TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase by LEE, DAVID C., SUNNARBORG, SUSAN WOHLER, HINKLE, C. LEANN, MYERS, TIMOTHY J., STEVENSON, MARY, RUSSELL, WILLIAM E., CASTNER, BEVERLY J., GERHART, MARY J., PAXTON, RAYMOND J., BLACK, ROY A., CHANG, AILEEN, JACKSON, LESLIE F.

“…: EGF family growth factors, including transforming growth factor‐alpha (TGFα), amphiregulin (AR), and heparin‐binding EGF (HB‐EGF), are invariably expressed…”
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An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation by MacDonald, Kelli P.A., Palmer, James S., Cronau, Stephen, Seppanen, Elke, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon, Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R., Hume, David A.

“…The development of the mononuclear phagocyte system requires macrophage colony-stimulating factor (CSF-1) signaling through the CSF-1 receptor (CSF1R, CD115)…”
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A Proteomic Approach for the Identification of Cell-surface Proteins Shed by Metalloproteases by Guo, Lin, Eisenman, June R, Mahimkar, Rajeev M, Peschon, Jacques J, Paxton, Raymond J, Black, Roy A, Johnson, Richard S

“…Proteolytic cleavage (shedding) of extracellular domains of many membrane proteins by metalloproteases is an important regulatory mechanism used by mammalian…”
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Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability by Sunnarborg, Susan Wohler, Hinkle, C. Leann, Stevenson, Mary, Russell, William E., Raska, Christina S., Peschon, Jacques J., Castner, Beverly J., Gerhart, Mary J., Paxton, Raymond J., Black, Roy A., Lee, David C.

“…We previously implicated tumor necrosis factor-α converting enzyme (TACE/ADAM17) in the processing of the integral membrane precursor to soluble transforming…”
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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells by Black, Roy A, Rauch, Charles T, Kozlosky, Carl J, Peschon, Jacques J, Slack, Jennifer L, Wolfson, Martin F, Castner, Beverly J, Stocking, Kim L, Reddy, Pranitha, Srinivasan, Subhashini, Nelson, Nicole, Boiani, Norman, Schooley, Kenneth A, Gerhart, Mary, Davis, Raymond, Fitzner, Jeffrey N, Johnson, Richard S, Paxton, Raymond J, March, Carl J, Cerretti, Douglas Pat

“…Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. Modification of the cell surface in this way can alter…”
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Molecular cloning and biological characterization of a novel murine lymphoid growth factor by Sims, J E, Williams, D E, Morrissey, P J, Garka, K, Foxworthe, D, Price, V, Friend, S L, Farr, A, Bedell, M A, Jenkins, N A, Copeland, N G, Grabstein, K, Paxton, R J

“…Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated…”
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Crystal Structure of the Catalytic Domain of Human Tumor Necrosis factor-α -converting Enzyme by Maskos, Klaus, Fernandez-Catalan, Carlos, Huber, Robert, Bourenkov, Gleb P., Bartunik, Hans, Ellestad, George A., Reddy, Pranitha, Wolfson, Martin F., Rauch, Charles T., Castner, Beverly J., Davis, Raymond, Howard R. G. Clarke, Petersen, Melissa, Fitzner, Jeffrey N., Cerretti, Douglas Pat, March, Carl J., Paxton, Raymond J., Black, Roy A., Bode, Wolfram

“…Tumor necrosis factor-α (TNFα ) is a cytokine that induces protective inflammatory reactions and kills tumor cells but also causes severe damage when produced…”
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Identification of 14−3−3ζ by Chemical Affinity with Salicylanilide Inhibitors of Interleukin-12p40 Production by Boyce, Jim P, Brown, Michael E, Chin, Wilson, Fitzner, Jeffrey N, Paxton, Raymond J, Shen, Min, Stevens, Tracey, Wolfson, Martin F, Wright, Clifford D

“…Salicylanilides were found as selective inhibitors of interleukin-12p40 production in stimulated dendritic cells. The conversion of one of these bioactive…”
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Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site by Wang, Xiangdong, He, Kai, Gerhart, Mary, Huang, Yao, Jiang, Jing, Paxton, Raymond J, Yang, Shaohua, Lu, Chunxia, Menon, Ram K, Black, Roy A, Baumann, Gerhard, Frank, Stuart J

“…Growth hormone-binding protein (GHBP) is complexed to a substantial fraction of circulating GH. In humans, rabbits, and other species, GHBP derives from…”
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INTERLEUKIN-15 INTERACTIONS WITH INTERLEUKIN-15 RECEPTOR COMPLEXES: CHARACTERIZATION AND SPECIES SPECIFICITY by Eisenman, June, Ahdieh, Minoo, Beers, Courtney, Brasel, Kenneth, Kennedy, Mary K., Le, Tiep, Bonnert, Timothy P., Paxton, Raymond J., Park, Linda S.

“…Interleukin (IL-) 2 and IL-15 share the IL-2 receptor βγ c subunits (IL-2Rβγ c) but have specific, unique α receptor subunits. We studied species specificity…”
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Carboranyl peptide-antibody conjugates for neutron-capture therapy: preparation, characterization, and in vivo evaluation by Paxton, Raymond J, Beatty, Barbara G, Varadarajan, Aravamuthan, Hawthorne, M. Frederick

“…Two model peptides rich in boron and prepared by Merrifield syntheses, dansyl.(nido-CB)2, (1) and dansyl.(nido-CB)10.Lys.Ac (2), where nido-CB represents the…”
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Reduced Proteolysis of Rabbit Growth Hormone (GH) Receptor Substituted with Mouse GH Receptor Cleavage Site by Wang, Xiangdong, He, Kai, Gerhart, Mary, Jiang, Jing, Paxton, Raymond J, Menon, Ram K, Black, Roy A, Baumann, Gerhard, Frank, Stuart J

“…GH binding protein (GHBP) is a circulating form of the GH receptor (GHR) extracellular domain, which derives by alternative splicing of the GHR gene (in mice…”
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Measurement of interleukin 15 by Paxton, Raymond J

“…Interleukin 15 (IL-15) is a small helical cytokine that was first characterized by its ability to stimulate proliferation of the murine T cell line CTLL-2, but…”
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Metalloprotease-mediated GH Receptor Proteolysis and GHBP Shedding by Wang, Xiangdong, He, Kai, Gerhart, Mary, Huang, Yao, Jiang, Jing, Paxton, Raymond J., Yang, Shaohua, Lu, Chunxia, Menon, Ram K., Black, Roy A., Baumann, Gerhard, Frank, Stuart J.

“…Growth hormone-binding protein (GHBP) is complexed to a substantial fraction of circulating GH. In humans, rabbits, and other species, GHBP derives from…”
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Antigenic sites in carcinoembryonic antigen by HAMMARSTROM, S, SHIVELY, J. E, SEGUIN, P, DARBOURET, B, DEGORCE, F, SERTOUR, J, JOLU, J. P, FUKS, A, KALTHOFF, H, SCHMIEGEL, W, ARNDT, R, KLOPPEL, G, PAXTON, R. J, VON KLEIST, S, GRUNERT, F, SCHWARZ, K, MATSUOKA, Y, KUROKI, M, BEATTY, B. G, LARSSON, A, GHOSH, R, BORMER, O, BUCHEGGER, F, MACH, J.-P, BURTIN, P

“…The epitope reactivities of 52 well-characterized monoclonal antibodies (Mabs) against carcinoembryonic antigen from 11 different research groups were studied…”
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Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and chinese hamster ovary cells by NEUMAIER, M, SHIVELY, L, FUN-SHAN CHEN, GAIDA, F.-J, ILGEN, C, PAXTON, R. J, SHIVELY, J. E, RIGGS, A. D

“…Carcinoembryonic antigen (CEA) is one of the best characterized tumor-associated antigens and is extensively used in the in vitro immunodiagnosis of human…”
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Radiometallacarboranes as tumor imaging reagents by Hawthorne, M. Frederick, Varadarajan, Aravamuthan, Knobler, Carolyn B, Chakrabarti, Sarmistha, Paxton, Raymond J, Beatty, Barbara G, Curtis, Frederick L

“…Monoclonal antibodies (Mab), when conjugated with bifunctional chelation reagents containing a radiometal, have provided sensitive and accurate imaging agents…”
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An Essential Role for Ectodomain Shedding in Mammalian Development by Peschon, Jacques J., Slack, Jennifer L., Reddy, Pranitha, Stocking, Kim L., Sunnarborg, Susan W., Lee, David C., Russell, William E., Castner, Beverly J., Johnson, Richard S., Fitzner, Jeffrey N., Boyce, Rogely W., Nelson, Nicole, Kozlosky, Carl J., Wolfson, Martin F., Rauch, Charles T., Cerretti, Douglas Pat, Paxton, Raymond J., March, Carl J., Black, Roy A.

“…The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis…”
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The effects of hyperthermia on tumor carcinoembryonic antigen expression by Wong, J Y, Mivechi, N F, Paxton, R J, Williams, L E, Beatty, B G, Beatty, J D, Shively, J E

“…The effects of hyperthermia on carcinoembryonic antigen (CEA) expression were investigated. The human colon adenocarcinoma cell line, LS174T, was heated in…”
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Identification and characterization of new antigenic fragments related to carcinoembryonic antigen in adult feces by HENSLEE, J. G, VACHULA, E. J, PAXTON, R. J, MATIAS, M. S, SHIVELY, J. E, RITTENHOUSE, H. G, TOMITA, J. T

“…Antigens in human adult feces related to carcinoembryonic antigen (CEA) were analyzed with respect to their molecular masses, CEA domain compositions, and…”
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