Search Results - "Paxman, Jason J."

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment by Owyong, Tze Cin, Subedi, Pramod, Deng, Jieru, Hinde, Elizabeth, Paxman, Jason J., White, Jonathan M., Chen, Weisan, Heras, Begoña, Wong, Wallace W. H., Hong, Yuning

“…Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general method of using the…”
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Phylogenetic Classification and Functional Review of Autotransporters by Clarke, Kaitlin R., Hor, Lilian, Pilapitiya, Akila, Luirink, Joen, Paxman, Jason J., Heras, Begoña

“…Autotransporters are the core component of a molecular nano-machine that delivers cargo proteins across the outer membrane of Gram-negative bacteria. Part of…”
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Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents by Smith, Roxanne P, Paxman, Jason J, Scanlon, Martin J, Heras, Begoña

“…Recent years have witnessed a dramatic increase in bacterial antimicrobial resistance and a decline in the development of novel antibiotics. New therapeutic…”
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antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping by Heras, Begoña, Totsika, Makrina, Peters, Kate M, Paxman, Jason J, Gee, Christine L, Jarrott, Russell J, Perugini, Matthew A, Whitten, Andrew E, Schembri, Mark A

“…Aggregation and biofilm formation are critical mechanisms for bacterial resistance to host immune factors and antibiotics. Autotransporter (AT) proteins, which…”
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Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function by Hor, Lilian, Pilapitiya, Akila, McKenna, James A., Panjikar, Santosh, Anderson, Marilyn A., Desvaux, Mickaël, Paxman, Jason J., Heras, Begoña

“…Autotransporters (ATs) are a large family of bacterial secreted and outer membrane proteins that encompass a wide range of enzymatic activities frequently…”
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Genome-Wide Analysis of Antigen 43 (Ag43) Variants: New Insights in Their Diversity, Distribution and Prevalence in Bacteria by Ageorges, Valentin, Wawrzyniak, Ivan, Ruiz, Philippe, Bicep, Cédric, Zorgani, Mohamed A, Paxman, Jason J, Heras, Begoña, Henderson, Ian R, Leroy, Sabine, Bailly, Xavier, Sapountzis, Panagiotis, Peyretaillade, Eric, Desvaux, Mickaël

“…Antigen 43 (Ag43) expression induces aggregation and biofilm formation that has consequences for bacterial colonisation and infection. Ag43 is secreted through…”
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Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules by Paxman, Jason J., Lo, Alvin W., Sullivan, Matthew J., Panjikar, Santosh, Kuiper, Michael, Whitten, Andrew E., Wang, Geqing, Luan, Chi-Hao, Moriel, Danilo G., Tan, Lendl, Peters, Kate M., Phan, Minh-Duy, Gee, Christine L., Ulett, Glen C., Schembri, Mark A., Heras, Begoña

“…Autotransporters are the largest family of outer membrane and secreted proteins in Gram-negative bacteria. Most autotransporters are localised to the bacterial…”
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Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target by Soares da Costa, Tatiana P., Desbois, Sebastien, Dogovski, Con, Gorman, Michael A., Ketaren, Natalia E., Paxman, Jason J., Siddiqui, Tanzeela, Zammit, Leanne M., Abbott, Belinda M., Robins-Browne, Roy M., Parker, Michael W., Jameson, Geoffrey B., Hall, Nathan E., Panjikar, Santosh, Perugini, Matthew A.

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the lysine biosynthesis pathway of bacteria. The pathway can be regulated by…”
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A Buried Water Network Modulates the Activity of the Escherichia coli Disulphide Catalyst DsbA by Wang, Geqing, Qin, Jilong, Verderosa, Anthony D, Hor, Lilian, Santos-Martin, Carlos, Paxman, Jason J, Martin, Jennifer L, Totsika, Makrina, Heras, Begoña

“…The formation of disulphide bonds is an essential step in the folding of many proteins that enter the secretory pathway; therefore, it is not surprising that…”
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Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein by Moriel, Danilo G, Heras, Begoña, Paxman, Jason J, Lo, Alvin W, Tan, Lendl, Sullivan, Matthew J, Dando, Samantha J, Beatson, Scott A, Ulett, Glen C, Schembri, Mark A

“…Urinary tract infection (UTI) is a disease of extremely high incidence in both community and nosocomial settings. UTIs cause significant morbidity and…”
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Variation of Antigen 43 self-association modulates bacterial compacting within aggregates and biofilms by Vo, Julieanne L., Ortiz, Gabriela C. Martínez, Totsika, Makrina, Lo, Alvin W., Hancock, Steven J., Whitten, Andrew E., Hor, Lilian, Peters, Kate M., Ageorges, Valentin, Caccia, Nelly, Desvaux, Mickaël, Schembri, Mark A., Paxman, Jason J., Heras, Begoña

“…The formation of aggregates and biofilms enhances bacterial colonisation and infection progression by affording protection from antibiotics and host immune…”
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The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes by Paxman, Jason J., Borg, Natalie A., Horne, James, Thompson, Philip E., Chin, Yanni, Sharma, Pooja, Simpson, Jamie S., Wielens, Jerome, Piek, Susannah, Kahler, Charlene M., Sakellaris, Harry, Pearce, Mary, Bottomley, Stephen P., Rossjohn, Jamie, Scanlon, Martin J.

“…Oxidative protein folding in Gram-negative bacteria results in the formation of disulfide bonds between pairs of cysteine residues. This is a multistep process…”
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Bioinformatics Tools and Resources for Analyzing Protein Structures by Paxman, Jason J, Heras, Begoña

“…The dramatic increase in the number of protein sequences and structures deposited in biological databases has led to the development of many bioinformatics…”
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The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance by Subedi, Pramod, Paxman, Jason J., Wang, Geqing, Ukuwela, Ashwinie A., Xiao, Zhiguang, Heras, Begoña

“…The human pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) contains a complex disulfide bond (Dsb) catalytic machinery. This machinery…”
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Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis by Nagpal, Jyotsna, Paxman, Jason J., Zammit, Jessica E., Thomas, Adam A., Truscott, Kaye N., Heras, Begoña, Dougan, David A.

“…The ClpP protease is found in all kingdoms of life, from bacteria to humans. In general, this protease forms a homo-oligomeric complex composed of 14 identical…”
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Autotransporter Adhesins in Escherichia coli Pathogenesis by Vo, Julieanne L., Martínez Ortiz, Gabriela Constanza, Subedi, Pramod, Keerthikumar, Shivakumar, Mathivanan, Suresh, Paxman, Jason J., Heras, Begoña

“…Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial…”
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Salmonella enterica BcfH Is a Trimeric Thioredoxin-Like Bifunctional Enzyme with Both Thiol Oxidase and Disulfide Isomerase Activities by Subedi, Pramod, Paxman, Jason J, Wang, Geqing, Hor, Lilian, Hong, Yaoqin, Verderosa, Anthony D, Whitten, Andrew E, Panjikar, Santosh, Santos-Martin, Carlos F, Martin, Jennifer L, Totsika, Makrina, Heras, Begoña

“…Thioredoxin (TRX)-fold proteins are ubiquitous in nature. This redox scaffold has evolved to enable a variety of functions, including redox regulation, protein…”
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Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V by Atkinson, Sarah C., Audsley, Michelle D., Lieu, Kim G., Marsh, Glenn A., Thomas, David R., Heaton, Steven M., Paxman, Jason J., Wagstaff, Kylie M., Buckle, Ashley M., Moseley, Gregory W., Jans, David A., Borg, Natalie A.

“…Hendra virus (HeV) is a paramyxovirus that causes lethal disease in humans, for which no vaccine or antiviral agent is available. HeV V protein is central to…”
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Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens by Smith, Roxanne P., Mohanty, Biswaranjan, Mowlaboccus, Shakeel, Paxman, Jason J., Williams, Martin L., Headey, Stephen J., Wang, Geqing, Subedi, Pramod, Doak, Bradley C., Kahler, Charlene M., Scanlon, Martin J., Heras, Begoña

“…The worldwide incidence of neisserial infections, particularly gonococcal infections, is increasingly associated with antibiotic-resistant strains. In…”
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Front Cover: Autotransporter Adhesins in Escherichia coli Pathogenesis by Vo, Julieanne L., Martínez Ortiz, Gabriela Constanza, Subedi, Pramod, Keerthikumar, Shivakumar, Mathivanan, Suresh, Paxman, Jason J., Heras, Begoña

“…DOI: 10.1002/pmic.201600431 Autotransporter proteins are the largest family of secreted proteins in Gram‐negative bacteria. As discussed in article number…”
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