Neurocognitive disorder in hypertensive patients. Heart–Brain Study

Neurocognitive disorder in hypertensive patients. Heart–Brain Study

Abstract The relation between hypertension and cognitive impairment is an undisputable fact. The aims of this study were to determine the prevalence of cognitive impairment in hypertensive patients, to identify the most affected cognitive domain, and to observe the association with different paramet...

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Bibliographic Details
Published in:Hipertension y riesgo vascular Vol. 35; no. 4; pp. 169 - 176
Main Authors: Vicario, A, Cerezo, G.H, del Sueldo, M, Zilberman, J, Pawluk, S.M, Lódolo, N, De Cerchio, A.E, Ruffa, R.M, Plunkett, R, Giuliano, M.E, Forcada, P, Hauad, S, Flores, R
Format: Journal Article
Language:English
Published: Spain Elsevier España, S.L.U 01-10-2018
Subjects:
Age Factors
Aged
Anthropometry
Argentina - epidemiology
Blood Pressure
Cardiovascular
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - etiology
Cognitive impairment
Cross-Sectional Studies
Deterioro cognitivo
Disfunción ejecutiva
Executive dysfunction
Executive Function
Factores de riesgo vascular
Female
Hipertensión
Humans
Hypertension
Hypertension - complications
Hypertension - psychology
Male
Memoria semántica
Memory Disorders - diagnostic imaging
Memory Disorders - etiology
Mental Status and Dementia Tests
Middle Aged
Risk Factors
Semantic memory
Sex Factors
Urban Population
Vascular risk factors
Argentina
Semantic memory
HTN
Mini-BNT
systolic blood pressure
BP
Executive dysfunction
CDT
DBP
diastolic blood pressure
MMSE
Mini-Boston Naming Test
SBP
Clock Drawing Test
blood pressure
Disfunción ejecutiva
CI
HADS
Hipertensión
MCE
Hospital Anxiety and Depression Scale
minimal cognitive examination
Memoria semántica
Deterioro cognitivo
Factores de riesgo vascular
cognitive impairment
Mini Mental State Examination
hypertension
Vascular risk factors
Hypertension
Cognitive impairment
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Summary:Abstract The relation between hypertension and cognitive impairment is an undisputable fact. The aims of this study were to determine the prevalence of cognitive impairment in hypertensive patients, to identify the most affected cognitive domain, and to observe the association with different parameters of hypertension and other vascular risk factors. A multicentre study was carried out, and 1281 hypertensive patients of both genders and ≥21 years of age were included. Data on the following parameters were obtained: cognitive status (Minimal Cognitive Examination), behavioural status (Hospital Anxiety and Depression Scale), blood pressure, anthropometry, and biochemical profile. The average age was 60.2 ± 13.5 years (71% female), and the educational level was 9.9 ± 5.1 years. Global cognitive impairment was seen in 22.1%, executive dysfunction in 36.2%, and semantic memory impairment in 48.9%. Cognitive impairment was higher in males (36.8% vs. 30.06%) within both the 70–79-year-old and the ≥80-year-old (50% vs. 40%) age groups. Abnormal Clock Drawing Test results were related to high pulse pressure ( p < 0.0036), and abnormal Mini-Boston Naming Test results to both high systolic blood pressure ( p < 0.052) and pulse pressure ( p < 0.001). The treated/uncontrolled hypertensive group showed abnormal results both in the Mini Mental State Examination (OR, 0.73; p = 0.036) and the Mini-Boston Naming Test (OR, 1.36; p = 0.021). Among patients without cognitive impairment (MMSE >24), 29.4% presented executive dysfunction, and 41.5% semantic memory impairment. Cognitive impairment was higher in hypertensive patients than in the general population. Executive functions and semantic memory were the most affected cognitive domains. High systolic blood pressure and pulse pressure were associated with abnormal results in cognitive tests.
ISSN:1889-1837
1989-4805
DOI:10.1016/j.hipert.2018.01.004