Search Results - "Pawluczyk, Izabella Z. A."

Combined walking exercise and alkali therapy in patients with CKD4–5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression by Watson, Emma L., Kosmadakis, George C., Smith, Alice C., Viana, Joao L., Brown, Jeremy R., Molyneux, Karen, Pawluczyk, Izabella Z. A., Mulheran, Michael, Bishop, Nicolette C., Shirreffs, Susan, Maughan, Ronald J., Owen, Paul J., John, Stephen G., McIntyre, Christopher W., Feehally, John, Bevington, Alan

“…Muscle-wasting in chronic kidney disease (CKD) arises from several factors including sedentary behaviour and metabolic acidosis. Exercise is potentially…”
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Kallikrein gene ‘knock-down’ by small interfering RNA transfection induces a profibrotic phenotype in rat mesangial cells by Pawluczyk, Izabella ZA, Tan, Eddie KC, Lodwick, David, Harris, Kevin PG

“…BACKGROUNDEmerging evidence suggests that kallikrein exerts renoprotective effects independent of its haemodynamic actions. The aim of the current…”
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Perindoprilat Modulates the Activity of Lipoprotein Receptor-related Protein in Human Mesangial Cells by Pawluczyk, Izabella Z.A., Patel, Samita R., Harris, Kevin P.G.

“…Low density lipoprotein receptor-related protein (LRP) is a multifunctional endocytic receptor implicated in the modulation of a number of cellular processes,…”
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Sialic acid attenuates puromycin aminonucleoside-induced desialylation and oxidative stress in human podocytes by Pawluczyk, Izabella Z.A., Ghaderi Najafabadi, Maryam, Patel, Samita, Desai, Priyanka, Vashi, Dipti, Saleem, Moin A, Topham, Peter S

“…Sialoglycoproteins make a significant contribution to the negative charge of the glomerular anionic glycocalyx—crucial for efficient functioning of the…”
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The role of the α-1 adrenoceptor in modulating human mesangial cell matrix production by Pawluczyk, Izabella Z. A., Patel, Samita R., Harris, Kevin P. G.

“…Background. The sympathetic nervous system is frequently activated in hypertension and may modify various aspects of renal function. Whether modulation of the…”
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Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression by Pawluczyk, Izabella Z A, Didangelos, Athanasios, Barbour, Sean J, Er, Lee, Becker, Jan U, Martin, Roberto, Taylor, Scott, Bhachu, Jasraj S, Lyons, Edward G, Jenkins, Robert H, Fraser, Donald, Molyneux, Karen, Perales-Patón, Javier, Saez-Rodriguez, Julio, Barratt, Jonathan

“…Understanding why certain patients with IgA nephropathy progress to kidney failure while others maintain normal kidney function remains a major unanswered…”
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Rat mesangial cells exhibit sex-specific profibrotic and proinflammatory phenotypes by Pawluczyk, Izabella Z. A., Tan, Eddie K. C., Harris, Kevin P. G.

“…Background. Chronic renal disease progresses more rapidly in males compared to females. This study investigated whether there were any inherent differences…”
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Low-level C-reactive protein levels exert cytoprotective actions on human podocytes by Pawluczyk, Izabella Z.A., Yang, Bin, Patel, Samita R., Saleem, Moin A., Topham, Peter S.

“…Background. Albuminuria and elevated C-reactive protein (CRP) levels are common manifestations of many inflammatory diseases. Cardiovascular-based drugs, with…”
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MicroRNA-23b-3p Deletion Induces an IgA Nephropathy-like Disease Associated with Dysregulated Mucosal IgA Synthesis by Li, Hongzhi, Chen, Zhichao, Chen, Weitian, Li, Jingyi, Liu, Yunshuang, Ma, Hongchuang, Shi, Mingming, Sun, Xuelian, Yao, Xiusong, Li, Zhijun, Pawluczyk, Izabella Z A, Zhang, Shuchen, Barratt, Jonathan, Lv, Jicheng, Wang, Kai, Zhao, Binghai

“…IgA nephropathy (IgAN) is the most common primary GN worldwide. Circulating immune complexes form that are prone to deposition in the mesangium, where they…”
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Macrophage interactions with collecting duct epithelial cells are capable of driving tubulointerstitial inflammation and fibrosis in immunoglobulin A nephropathy by Pawluczyk, Izabella Z A, Soares, Maria S F, Barratt, William A, Brown, Jeremy R, Bhachu, Jasraj S, Selvaskandan, Haresh, Zeng, Yiqing, Sarania, Rishi, Molyneux, Karen, Roberts, Ian S D, Barratt, Jonathan

“…Tubulointerstitial fibrosis is a powerful predictor of future progression inimmunoglobulin A (IgA) nephropathy (IgAN). Proximal tubular epithelial cells…”
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Effect of angiotensin type 2 receptor over-expression on the rat mesangial cell fibrotic phenotype: effect of gender by Pawluczyk, Izabella ZA, Harris, Kevin PG

“…Background and aim: The protective role of angiotensin type 2 receptors (AT2-Rs) is still controversial. As AT2-Rs are minimally expressed in adult tissues the…”
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The Non-Coding RNA Landscape in IgA Nephropathy—Where Are We in 2021? by Pawluczyk, Izabella Z. A., Selvaskandan, Haresh, Barratt, Jonathan

“…IgA nephropathy (IgAN) is the most commonly diagnosed primary glomerulonephritis worldwide. It is a slow progressing disease with approximately 30% of cases…”
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Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats by Pawluczyk, Izabella Z A, Najafabadi, Maryam G, Brown, Jeremy R, Bevington, Alan, Topham, Peter S

“…Defects in sialylation are known to have serious consequences on podocyte function leading to collapse of the glomerular filtration barrier and the development…”
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Glucocorticoid antagonist RU38486 fails to block acid-induced muscle wasting in vivo or in vitro by Pickering, Warren P., Baker, Frease E., Brown, Jeremy, Butler, Heather L., Govindji, Sheena, Parsons, Julie M., Pawluczyk, Izabella Z. A., Walls, John, Bevington, Alan

“…Background. Increased protein degradation during metabolic acidosis contributes to muscle wasting in uraemia. Adrenalectomy experiments in severely acidotic…”
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Inflammation and caspase activation in long-term renal ischemia/reperfusion injury and immunosuppression in rats by Yang, B.I.N., Jain, Sunjay, Pawluczyk, Izabella Z.A., Imtiaz, Shehla, Bowley, Lee, Ashra, Shairbanu Y., Nicholson, Michael L.

“…Inflammation and caspase activation in long-term renal ischemia/reperfusion injury and immunosuppression in rats. We have previously shown the long-term…”
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The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells by Pawluczyk, Izabella Z.A., Patel, Samita R., Harris, Kevin P.G.

“…The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells. Angiotensin-converting enzyme inhibitors (ACE-I) protect against…”
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Effects of glucose dialysate on extracellular matrix production by human peritoneal mesothelial cells (HPMC): the role of TGF‐β by Medcalf, James F., Walls, John, Pawluczyk, Izabella Z. A., Harris, Kevin P. G.

“…Background. Dialysate glucose has been implicated in the loss of peritoneal membrane function seen in long‐term CAPD patients. Methods. In order to investigate…”
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Pharmacological Enhancement of the Kallikrein-Kinin System Promotes Anti-Fibrotic Responses in Human Mesangial Cells by Pawluczyk, Izabella, Patel, Samita, Harris, Kevin

“…The aim of the present study was to investigate whether pharmacological enhancement of the renal kallikrein-kinin system using the vasopeptidase inhibitor…”
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The role of the [alpha]-1 adrenoceptor in modulating human mesangial cell matrix production by Pawluczyk, Izabella Z A, Patel, Samita R, Harris, Kevin P G

“…Background. The sympathetic nervous system is frequently activated in hypertension and may modify various aspects of renal function. Whether modulation of the…”
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Transforming growth factor- suppresses macrophage-induced mesangial cell fibronectin expression by Pawluczyk, Izabella Z A, Harris, Kevin P G

“…We have previously shown that macrophages are able to promote prosclerotic responses in rat mesangial cells. Th2-type cytokines, including interleukin-10…”
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