Search Results - "Pawlick, Rena"

Ferroptosis-inducing agents compromise in vitro human islet viability and function by Bruni, Antonio, Pepper, Andrew R., Pawlick, Rena L., Gala-Lopez, Boris, Gamble, Anissa F., Kin, Tatsuya, Seeberger, Karen, Korbutt, Gregory S., Bornstein, Stefan R., Linkermann, Andreas, Shapiro, A. M. James

“…Human islet transplantation has been hampered by donor cell death associated with the islet preparation procedure before transplantation. Regulated necrosis…”
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Lung-Derived Microscaffolds Facilitate Diabetes Reversal after Mouse and Human Intraperitoneal Islet Transplantation by Abualhassan, Nasser, Sapozhnikov, Lena, Pawlick, Rena L, Kahana, Meygal, Pepper, Andrew R, Bruni, Antonio, Gala-Lopez, Boris, Kin, Tatsuya, Mitrani, Eduardo, Shapiro, A M James

“…There is a need to develop three-dimensional structures that mimic the natural islet tissue microenvironment. Endocrine micro-pancreata (EMPs) made up of…”
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Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells by Gamble, Anissa, Pawlick, Rena, Pepper, Andrew R, Bruni, Antonio, Adesida, Adetola, Senior, Peter A, Korbutt, Gregory S, Shapiro, A M James

“…Islet transplantation is an established clinical procedure for select patients with type 1 diabetes and severe hypoglycemia to stabilize glycemic control…”
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Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonists in islet transplantation: Endogenous in vivo regulatory T cell expansion promotes prolonged allograft survival by Marfil‐Garza, Braulio A., Pawlick, Rena L., Szeto, Jake, Kroger, Charles, Tahiliani, Vikas, Hefler, Joshua, Dadheech, Nidheesh, Seavey, Mathew M., Wolf, Jeffrey, Jasuja, Rahul R., James Shapiro, A. M.

“…Regulatory T cells (Tregs) modulate alloimmune responses and may facilitate minimization or withdrawal of immunosuppression posttransplant. Current approaches,…”
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Preclinical models of acute liver failure: a comprehensive review by Hefler, Joshua, Marfil-Garza, Braulio A, Pawlick, Rena L, Freed, Darren H, Karvellas, Constantine J, Bigam, David L, Shapiro, A M James

“…Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare,…”
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Glutathione ethyl ester supplementation during pancreatic islet isolation improves viability and transplant outcomes in a murine marginal islet mass model by do Amaral, Alexandre S Raposo, Pawlick, Rena L, Rodrigues, Erika, Costal, Flavia, Pepper, Andrew, Galvão, Flávio H Ferreira, Correa-Giannella, Maria Lucia, Shapiro, A M James

“…The success of pancreatic islet transplantation still faces many challenges, mainly related to cell damage during islet isolation and early post-transplant…”
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Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model by Bral, Mariusz, Pawlick, Rena, Marfil-Garza, Braulio, Dadheech, Nidheesh, Hefler, Joshua, Thiesen, Aducio, Shapiro, A M James

“…Liver ischemia reperfusion injury (IRI) remains a challenge in liver transplantation. A number of compounds have previously demonstrated efficacy in mitigating…”
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BMX‐001, a novel redox‐active metalloporphyrin, improves islet function and engraftment in a murine transplant model by Bruni, Antonio, Pepper, Andrew R., Pawlick, Rena L., Gala‐Lopez, Boris, Gamble, Anissa, Kin, Tatsuya, Malcolm, Andrew J., Jones, Carissa, Piganelli, Jon D., Crapo, James D., Shapiro, A. M. James

“…Islet transplantation has become a well‐established therapy for select patients with type 1 diabetes. Viability and engraftment can be compromised by the…”
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Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site by Pepper, Andrew R., Pawlick, Rena, Bruni, Antonio, Wink, John, Rafiei, Yasmin, O’Gorman, Doug, Yan-Do, Richard, Gala-Lopez, Boris, Kin, Tatsuya, MacDonald, Patrick E., Shapiro, A.M. James

“…Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select humans with autoimmune diabetes. The scarcity of “healthy” human…”
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Harnessing the Foreign Body Reaction in Marginal Mass Device-less Subcutaneous Islet Transplantation in Mice by Pepper, Andrew R, Pawlick, Rena, Bruni, Antonio, Gala-Lopez, Boris, Wink, John, Rafiei, Yasmin, Bral, Mariusz, Abualhassan, Nasser, Shapiro, A. M James

“…BACKGROUNDIslet transplantation is a successful β-cell replacement therapy for selected patients with type 1 diabetes mellitus. However, despite early insulin…”
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Suspension culture improves iPSC expansion and pluripotency phenotype by Cuesta-Gomez, Nerea, Verhoeff, Kevin, Dadheech, Nidheesh, Dang, Tiffany, Jasra, Ila Tewari, de Leon, Mario Bermudez, Pawlick, Rena, Marfil-Garza, Braulio, Anwar, Perveen, Razavy, Haide, Zapata-Morin, Patricio Adrián, Jickling, Glen, Thiesen, Aducio, O'Gorman, Doug, Kallos, Michael S, Shapiro, A M James

“…Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal…”
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The Current Status of Allogenic Islet Cell Transplantation by Czarnecka, Zofia, Dadheech, Nidheesh, Razavy, Haide, Pawlick, Rena, Shapiro, A. M. James

“…Type 1 Diabetes (T1D) is an autoimmune destruction of pancreatic beta cells. The development of the Edmonton Protocol for islet transplantation in 2000…”
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Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice by Gala-Lopez, Boris L, Pepper, Andrew R, Pawlick, Rena L, O'Gorman, Doug, Kin, Tatsuya, Bruni, Antonio, Abualhassan, Nasser, Bral, Mariusz, Bautista, Austin, Manning Fox, Jocelyn E, Young, Lachlan G, MacDonald, Patrick E, Shapiro, A M James

“…Clinical islet transplantation has become an established treatment modality for selected patients with type 1 diabetes. However, a large proportion of…”
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Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression by Wang, Long-Hai, Marfil-Garza, Braulio A., Ernst, Alexander U., Pawlick, Rena L., Pepper, Andrew R., Okada, Kento, Epel, Boris, Viswakarma, Navin, Kotecha, Mrignayani, Flanders, James Arthur, Datta, Ashim K., Gao, Hong-Jie, You, Ye-Zi, Ma, Minglin, Shapiro, A. M. James

“…Cellular therapies for type-1 diabetes can leverage cell encapsulation to dispense with immunosuppression. However, encapsulated islet cells do not survive…”
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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury by Hefler, Joshua, Pawlick, Rena, Marfil-Garza, Braulio A., Thiesen, Aducio, Cuesta-Gomez, Nerea, Hatami, Sanaz, Freed, Darren H., Karvellas, Constantine, Bigam, David L., Shapiro, A.M. James

“…The liver is susceptible to ischemia-reperfusion injury (IRI) during hepatic surgery, when the vessels are compressed to control bleeding, or liver…”
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Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device by Pepper, Andrew R., Pawlick, Rena, Gala-Lopez, Boris, MacGillivary, Amanda, Mazzuca, Delfina M., White, David J. G., Toleikis, Philip M., Shapiro, A. M. James

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Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site by Pepper, Andrew R., Bruni, Antonio, Pawlick, Rena L., Gala-Lopez, Boris, Rafiei, Yasmin, Wink, John, Kin, Tatsuya, Shapiro, A. M. James

“…Clinical islet transplantation has routinely been demonstrated to be an efficacious means of restoring glycemic control in select patients with autoimmune…”
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The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice by McCall, Michael, MD, Toso, Christian, MD, PhD, Emamaullee, Juliet, MD, PhD, Pawlick, Rena, BSc, Edgar, Ryan, BSc, Davis, Joy, Maciver, Allison, MD, Kin, Tatsuya, MD, PhD, Arch, Robert, PhD, Shapiro, A.M. James, MD, PhD

“…Background Islet transplantation has become a viable option for selected type 1 diabetic patients; however, a significant portion need to return to exogenous…”
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Reparixin, a CXCR1/2 inhibitor in islet allotransplantation by Pawlick, Rena L., Wink, John, Pepper, Andrew R., Bruni, Antonio, Abualhassen, Nasser, Rafiei, Yasmin, Gala-Lopez, Boris, Bral, Mariusz, Shapiro, A.M. James

“…Quality of life in Type 1 diabetic patients may be improved with islet transplantation, but lifelong immunosuppression is required to prevent rejection…”
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Comparison of human islet isolation outcomes using a new mammalian tissue-free enzyme versus collagenase NB-1 by O'Gorman, Doug, Kin, Tatsuya, Imes, Sharleen, Pawlick, Rena, Senior, Peter, Shapiro, A M James

“…After the discontinuation of the manufacturing Liberase HI because of a small potential for prion disease transmission, Roche Diagnostics (Indianapolis, IN)…”
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