Search Results - "Pawlak, Sebastian D."
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Anti-EGFR Agents: Current Status, Forecasts and Future Directions
Published in Targeted oncology (01-12-2016)“…The epidermal growth factor receptor (EGFR) is one of the most important and attractive targets for specific anticancer therapies. It is a robust regulator of…”
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Improved cytotoxicity of novel TRAIL variants produced as recombinant fusion proteins
Published in Protein engineering, design and selection (01-02-2018)“…Abstract The TNF-Related Apoptosis Inducing Ligand (TRAIL) cytokine triggers apoptosis specifically in cancer cells. Susceptibility of a given cell to TRAIL…”
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AD-O53.2—a novel recombinant fusion protein combining the activities of TRAIL/Apo2L and Smac/Diablo, overcomes resistance of human cancer cells to TRAIL/Apo2L
Published in Investigational new drugs (01-12-2014)“…Summary Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors became promising molecules for selective targeting of tumor cells…”
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Human ATP‐dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP
Published in The FEBS journal (01-10-2005)“…The human SUV3gene encodes an NTP‐dependent DNA/RNA DExH box helicase predominantly localized in mitochondria. Its orthologue in yeast is a component of the…”
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Inference of relationships in the ‘twilight zone’ of homology using a combination of bioinformatics and site-directed mutagenesis: a case study of restriction endonucleases Bsp6I and PvuII
Published in Nucleic acids research (01-01-2005)“…Thus far, identification of functionally important residues in Type II restriction endonucleases (REases) has been difficult using conventional methods. Even…”
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A theoretical model of restriction endonuclease NlaIV in complex with DNA, predicted by fold recognition and validated by site-directed mutagenesis and circular dichroism spectroscopy
Published in Protein engineering, design and selection (01-04-2005)“…Restriction enzymes (REases) are commercial reagents commonly used in DNA manipulations and mapping. They are regarded as very attractive models for studying…”
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Biophysical Studies of TRAIL-Based Anticancer Fusion Protein AD 051.4
Published in Biophysical journal (03-02-2017)Get full text
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Abstract 3796: Biochemical and biophysical characterization of AD-O51.4 a novel anticancer biological therapeutic agent with dual mechanism of action
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Background Cancer growth and development is tightly related to both new vessels formation for tissue remodeling and inhibition of anti-apoptotic signals…”
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Abstract 5073: Novel fusion molecule with high dual antiangiogenic and anticancer potential
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…One of the most important mechanisms of tumorgenesis is formation of new blood vessels and tissue remodeling. Vascular endothelial growth factor (VEGF) is one…”
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Abstract 5488: Fusion protein capable to initiate two apoptotic pathways in cancer cells resistant to classical PARA's
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising antitumor agent, but its clinical utility in human malignancies is limited…”
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