Search Results - "Pawelek, Peter D."

Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type by Lerner-Ellis, Jordan P, Atkinson, Janet L, Dunbar, Gail V, Morgan, Kenneth, Hosack, Angela R, Gravel, Roy A, Lepage, Pierre, Tirone, Jamie C, Fujiwara, T Mary, Doré, Carole, Forgetta, Vince, Pawelek, Peter D, Antonicka, Hana, Shoubridge, Eric A, Coulton, James W, Rosenblatt, David S, Watkins, David, Moras, Emily, Leclerc, Daniel, Morel, Chantal F, Rommens, Johanna M, Dobson, C Melissa

“…Methylmalonic aciduria and homocystinuria, cblC type (OMIM 277400), is the most common inborn error of vitamin B12 (cobalamin) metabolism, with about 250 known…”
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Evidence of isochorismate channeling between the Escherichia coli enterobactin biosynthetic enzymes EntC and EntB by Bin, Xue, Pawelek, Peter D.

“…Enterobactin is a high‐affinity iron chelator produced and secreted by Escherichia coli and Salmonella typhimurium to scavenge scarce extracellular Fe3+ as a…”
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Dual Activity of Rose Bengal Functionalized to Albumin-Coated Lanthanide-Doped Upconverting Nanoparticles: Targeting and Photodynamic Therapy by Sabri, Tarek, Pawelek, Peter D, Capobianco, John A

“…A modified version of a desolvation method was used to render lanthanide-doped upconverting nanoparticles NaGdF4:Yb3+/Er3+ (Ln-UCNPs) water-dispersible and…”
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Identification and Functional Characterization of a Novel Mutation in the Calcium-Sensing Receptor Gene in Familial Hypocalciuric Hypercalcemia: Modulation of Clinical Severity by Vitamin D Status by Zajickova, Katerina, Vrbikova, Jana, Canaff, Lucie, Pawelek, Peter D., Goltzman, David, Hendy, Geoffrey N.

“…Context: Familial hypocalciuric hypercalcemia (FHH) is a benign condition associated with heterogeneous inactivating mutations in the calcium-sensing receptor…”
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Ligand-Induced Conformational Rearrangements Promote Interaction between the Escherichia coli Enterobactin Biosynthetic Proteins EntE and EntB by Khalil, Sofia, Pawelek, Peter D.

“…Siderophores are small-molecule iron chelators that many bacteria synthesize and secrete in order to survive in iron-depleted environments. Biosynthesis of…”
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A Shared Binding Site for NAD+ and Coenzyme A in an Acetaldehyde Dehydrogenase Involved in Bacterial Degradation of Aromatic Compounds by Lei, Yu, Pawelek, Peter D, Powlowski, Justin

“…The meta-cleavage pathway for catechol is a central pathway for the bacterial dissimilation of a wide variety of aromatic compounds, including phenols,…”
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Evidence of an intracellular interaction between the Escherichia coli enzymes EntC and EntB and identification of a potential electrostatic channeling surface by Ouellette, Sylvie, Pakarian, Paknoosh, Bin, Xue, Pawelek, Peter D.

“…Siderophores are high-affinity small-molecule chelators employed by bacteria to acquire iron from the extracellular environment. The Gram-negative bacterium…”
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Intracellular co-localization of the Escherichia coli enterobactin biosynthetic enzymes EntA, EntB, and EntE by Pakarian, Paknoosh, Pawelek, Peter D.

“…Bacteria utilize small-molecule iron chelators called siderophores to support growth in low-iron environments. The Escherichia coli catecholate siderophore…”
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Interactions between TonB from Escherichia coli and the Periplasmic Protein FhuD by Carter, David M., Miousse, Isabelle R., Gagnon, Jean-Nicolas, Martinez, Éric, Clements, Abigail, Lee, Jongchan, Hancock, Mark A., Gagnon, Hubert, Pawelek, Peter D., Coulton, James W.

“…For uptake of ferrichrome into bacterial cells, FhuA, a TonB-dependent outer membrane receptor of Escherichia coli, is required. The periplasmic protein FhuD…”
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Siderophore Transport through Escherichia coli Outer Membrane Receptor FhuA with Disulfide-tethered Cork and Barrel Domains by Eisenhauer, H. Anne, Shames, Sofia, Pawelek, Peter D., Coulton, James W.

“…The hydroxamate siderophore receptor FhuA is a TonB-dependent outer membrane protein of Escherichia coli composed of a C-terminal 22-stranded β-barrel occluded…”
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The C-glycosyltransferase IroB from pathogenic Escherichia coli: Identification of residues required for efficient catalysis by Foshag, Daniel, Campbell, Cory, Pawelek, Peter D.

“…Escherichia coli C-glycosyltransferase IroB catalyzes the formation of a CC bond between enterobactin and the glucose moiety of UDP-glucose, resulting in the…”
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Phage display reveals multiple contact sites between FhuA, an outer membrane receptor of Escherichia coli, and TonB by Carter, David M, Gagnon, Jean-Nicolas, Damlaj, Moussab, Mandava, Suneeta, Makowski, Lee, Rodi, Diane J, Pawelek, Peter D, Coulton, James W

“…The ferric hydroxamate uptake receptor FhuA from Escherichia coli transports siderophores across the outer membrane (OM). TonB-ExbB-ExbD transduces energy from…”
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Subunit orientation in the Escherichia coli enterobactin biosynthetic EntA-EntE complex revealed by a two-hybrid approach by Pakarian, Paknoosh, Pawelek, Peter D.

“…The siderophore enterobactin is synthesized by the enzymes EntA-F and EntH in the Escherichia coli cytoplasm. We previously reported in vitro evidence of an…”
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A novel set of vectors for Fur-controlled protein expression under iron deprivation in Escherichia coli by Pakarian, Paknoosh, Pawelek, Peter D

“…In the presence of sufficient iron, the Escherichia coli protein Fur (Ferric Uptake Regulator) represses genes controlled by the Fur box, a consensus sequence…”
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Identification of a surface glutamine residue (Q64) of Escherichia coli EntA required for interaction with EntE by Khalil, Sofia, Jaworski, Ian, Pawelek, Peter D

“…The enterobactin biosynthetic enzyme EntA forms a complex with EntE, the next enzyme in the pathway, to enhance activation of the enterobactin precursor…”
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Structure of TonB in Complex with FhuA, E. coli Outer Membrane Receptor by Pawelek, Peter D, Croteau, Nathalie, Ng-Thow-Hing, Christopher, Khursigara, Cezar M, Moiseeva, Natalia, Allaire, Marc, Coulton, James W

“…The cytoplasmic membrane protein TonB spans the periplasm of the Gram-negative bacterial cell envelope, contacts cognate outer membrane receptors, and…”
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Enzymatic Adenylation of 2,3-Dihydroxybenzoate Is Enhanced by a Protein−Protein Interaction between Escherichia coli 2,3-Dihydro-2,3-dihydroxybenzoate Dehydrogenase (EntA) and 2,3-Dihydroxybenzoate-AMP Ligase (EntE) by Khalil, Sofia, Pawelek, Peter D

“…The Escherichia coli siderophore enterobactin is synthesized in response to iron starvation. 2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase (EntA) produces…”
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The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site by Pawelek, Peter D., Cheah, Jaime, Coulombe, Rene, Macheroux, Peter, Ghisla, Sandro, Vrielink, Alice

“…The structure of L‐amino acid oxidase (LAAO) from Calloselasma rhodostoma has been determined to 2.0 Å resolution in the presence of two ligands: citrate and…”
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Kinetic Analyses Reveal Multiple Steps in Forming TonB−FhuA Complexes from Escherichia coli by Khursigara, Cezar M, De Crescenzo, Gregory, Pawelek, Peter D, Coulton, James W

“…FhuA, an outer membrane receptor of Escherichia coli, facilitates transport of hydroxamate siderophores and siderophore−antibiotic conjugates. The cytoplasmic…”
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Deletion of the proline‐rich region of TonB disrupts formation of a 2:1 complex with FhuA, an outer membrane receptor of Escherichia coli by Khursigara, Cezar M., De Crescenzo, Gregory, Pawelek, Peter D., Coulton, James W.

“…TonB protein of Escherichia coli couples the electrochemical potential of the cytoplasmic membrane (CM) to active transport of iron‐siderophores and vitamin…”
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